Does the new Alzheimer's drug Aducanumab mean the end of Alzheimer's? with Marwan Sabbagh, MD.
Release Date: 06/30/2021
Alzheimer’s Disease - Going Beyond the Hypothesis
Evolving Past Alzheimer's
What if what we thought to be the primary cause ofAlzheimer'swas not true? Dr. NateBergman delves into a research article published by Dr. Weaver to assess if the primary cause of Alzheimer's can be limited to only the amyloid area. For years it has been believed that the main causes of Alzheimer’s disease are the abnormal build-up of proteins in and around the brain cells. The main toxic protein involved in this is called the amyloid beta which accumulates and builds up like plaque around the brain cells. However, in recent times, the hypothesis that originated in 2006 and was believed by...
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Brain Stimulation for Early Alzheimer's Disease
Evolving Past Alzheimer's
In This Episode You Will Learn: Where are you in your career right now? Neuroscience research is fascinating. Dr. Ted is most interested in attention, perception, and memory. These three things work together harmoniously because you can’t remember something you ignore, and it’s difficult to notice something if you don’t perceive it in the beginning. Dr. Ted studied how the brain encodes beats. He uses music perception to enable people to pay attention, listen, and remember information. He worked with Adam Gaza and researched aging's attention, memory, and perception. Their...
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Strong Heart, Sharp Mind with Marwan Sabbagh MD
Evolving Past Alzheimer's
6 Effective Ways of Heart Disease Prevention Anyone who wishes to optimize health by protecting the heart and brain must listen to this! Dr. Marwan Sabbagh and Joe Piscatella combine the six most effective principles for heart disease prevention. They unfold valuable heart and brain facts in their new book Strong Heart, Sharp Mind, which are equally beneficial for the prevention of Alzheimer's disease. In a way, they open hope for effective heart disease treatments, dealing with Alzheimer's, and other brain ailments with a multidisciplinary approach. What is good for your heart is good for...
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Strong Heart, Sharp Mind with Marwan Sabbagh MD
Evolving Past Alzheimer's
A familiar guest rejoins us for the show! Marwan Sabbagh MD is currently a professor of Neurology at Barrow Neurological Institute and a leader in Alzheimer's disease diagnosis and treatment. Dr. Sabbagh and his bestselling co-author and heart disease survivor, Joe Piscatella reveals new hope for treating and preventing these heart, blood vessel, and brain diseases like Alzheimer's with their new book, Strong Heart, Sharp Mind. We discuss how, for the first time in his career, Dr Sabbagh is starting to see people with very early Alzheimer's hold the symptoms at bay. He attributes, in part, to...
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Plasma Exchange, Albumin & IVIg for Alzheimer's - AMBAR Trial Results with Merce Boada MD PhD
Evolving Past Alzheimer's
The conversation had on this episode is a little complex but is an excellent review in how science is done and "how the sausage is made" in terms of medical evidence in peer review for Alzheimer's treatments. We discuss the results of the - The Alzheimer Management by Albumin Replacement - where people with mild to moderate Alzheimer's showed significant improvements after having their blood plasma exchanged in addition to receiving either IV Albumin as well as IVIg (in some of the experimental groups). The study doesn't offer an explanation of the mechanisms around why Albumin...
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Towards Understanding "Lyme" & Alzheimer's Relationships with Alan MacDonald MD
Evolving Past Alzheimer's
In July 2021, the journal Frontiers in Neurology reported on "groundbreaking research" out of Tulane pointing to the relationship between Lyme disease and Alzheimer’s dementia. But since the 1980s our guest on this episode, Dr. Alan MacDonald, was stirring up the scientific debate by publishing and presenting data from his pathology laboratory that the bacteria - Borrelia Burgdorferi often synonymous with what's called Lyme disease, because of its association with its US origins in the town of Lyme, Connecticut. Dr. MacDonald graduated with an MD from Columbia University. ...
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Our Sense of Smell - Brainwaves of COVID and Alzheimer's with Thom Cleland PhD
Evolving Past Alzheimer's
This is a more theoretical episode that gives us some idea about what might be happening with the rhythms of an Alzheimer's or POST-COVID brain.
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Our Brains Need Meditation - Here's Why with Hemal Patel PhD
Evolving Past Alzheimer's
In this episode, we go deep into the potential benefits of specialized meditation for our immune systems, brain-related proteins, Alzheimer's, cellular energy, and much more. Our guest, Dr Hemal Patel - is a full professor and serves as the Vice-Chair for Research in the Department of Anesthesiology at the University of California, San Diego.
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Lisa's Story - Chap. 2 - Living Well with Alzheimer's
Evolving Past Alzheimer's
Earlier this year, podcast episode #65 - we spoke to Lisa and her daughters Stacy and Natalie. They told us about how they were Living Well with Alzheimer's and improving using lifestyle and personalized approach. Her cognitive decline had stabilized and seen small, but significant improvements in brain function. This episode we review some of the elements that have led to their success
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Usable Technology for Brain Aging & Dementia with Ben Hampstead PhD
Evolving Past Alzheimer's
“We’re actually able to change the brain, even in the face of things like Alzheimer’s disease.” This was the statement made by our guest for this show, Dr. Ben Hampstead. Dr. Hampstead is a professor at the Univ of Michigan and leads a lab that is doing several studies using transcranial direct current stimulation for mild cognitive impairment, Alzheimer's, and other forms of cognitive impairment.
info_outlineIn this episode, we hear the argument in favor of the new Alzheimer's drug, Aducanumab (Aduhelm). Dr. Marwan Sabbagh is a clinical and research leader at the Cleveland Clinic's Lou Ruvo Center for Brain Health. He was a doctor that saw patients in one of the trials that led to the FDA's Accelerated (provisional) Approval.
Note: Dr. Sabbagh notes his disclosure as an advisor to Biogen, the maker of Aducanumab.
We discuss what Dr. Sabbagh noted in his own patients involved in the recent Phase 3 clinical trial of Aducanumab.
Controversy over the FDA's decision and why Dr. Sabbagh's 25+ years of diagnosing and treating Alzheimer's makes him optimistic about this drug.
Dr. Sabbagh talks through who he thinks might be a good candidate for Aducanumab, the drug's known practical side effects, and how people might get access to the medication in the near future.
Ultimately, Dr. Sabbagh sees people in the near future living with Alzheimer's like a chronic disease much like HIV or diabetes, or even cancer.
This episode presents a slightly different perspective than many of our listeners are used to. We hope you find it useful.
2:33 - what is this new drug and how does it actually treat Alzheimer's
5:28 - Why Dr. Sabbagh is optimistic about this new drug
11:43 - Reasons for some of the skepticism around the study
14:11 - Dr. Sabbagh’s observations of the people who have taken the drug
21:10 - What are the risks of taking the drug?
27:08 - Responding to the criticism of the drug
32:30 - Other promising drugs that may be available in the future for Alzheimer's patients
37:18 - How do people get access to this new drug?