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The End of Alzheimer's? The heralded arrival of prevention and reversal with Dale Bredesen MD

Evolving Past Alzheimer's

Release Date: 11/01/2017

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Evolving Past Alzheimer's

Dr. Nate Bergman quickly summarizes the story up the FDA's recent "accelerated approval" of Biogen's - Aducanumab (brand named, Aduhelm). He ends off with surprise about why he is excited about the approval...and it's probably not what you think! A quick, but useful listen.

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Evolving Past Alzheimer's

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Evolving Past Alzheimer's

In this episode, we hear the argument in favor of the new Alzheimer's drug, Aducanumab (Aduhelm).  Dr. Marwan Sabbagh is a clinical and research leader at the Cleveland Clinic's Lou Ruvo Center for Brain Health. He was a doctor that saw patients in one of the trials that led to the FDA's Accelerated (provisional) Approval. 

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Evolving Past Alzheimer's

This week we will do almost a Part 2 from the last episode with Drs Dale Bredesen and Kat Toups.  In that episode, we featured recently released results data on MedArchive from a clinical trial in which 84% of 25 patients with early Alzheimer's Disease and Mild Cognitive Impairment improved with a Precision Medicine approach.  

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Evolving Past Alzheimer's

Our guests today are Drs Kat Toups & Dale Bredesen.

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Evolving Past Alzheimer's

Deborah Kan is a former executive producer with the Wall Street Journal. In 2017 she founded the website BeingPatient.com, a comprehensive website dedicated to Alzheimer's news, stories, and support.

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Evolving Past Alzheimer's

We are witnessing a sea change in dementia. More people are being diagnosed, earlier and younger. And people are figuring out how to actually fight back against the disease and taking ownership of their condition.

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George suffered a major brain injury as a result of his heart stopping about 4 years ago.  Fortunately, he has successfully recovered from the brain injury and this is the story of how the Mullers did it!

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Evolving Past Alzheimer's

We get many questions from listeners and people seeking Alzheimer’s prevention and early intervention about the risks and benefits of hormone therapies, such as estrogen and progesterone.

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Evolving Past Alzheimer's

In this episode, you'll meet the co-founders of Kemper House and Kemper Cognitive Wellness.

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Dr Dale Bredesen is an internationally recognized researcher in Alzheimer's.  His incredible resume includes being the Director of the Easton Center for Alzheimer's Research at UCLA as well as founding president and CEO of the Buck Institute on Aging in Novato, California.  He has worked in the lab of 2 nobel prize winners and has run his own labs for 28 years looking at neurodegenerative diseases - focusing on Alzheimer's.
Dr Bredesen's fundamental theory is that Alzheimer's is actually a protective brain response to different classes of insults.

Classes of Insults Leading to Alzheimer’s

  1. Inflammation and the brain’s response to pathogens/infections – these trigger the creation of amyloid beta, a key chemical in the brain that destroys brain cell connections and is believed to be a key factor in the development of Alzheimer’s. Amyloid Beta is a part of the Innate Immune system which seems to be over stimulated or dysregulated in most cases of Alzheimer’s. Dr. Bredesen explains the connection of immune activation in Alzheimer’s.
  2. Inadequate amounts OR withdrawal of support of brain-“growing” chemicals like B12, vitamin D, and other hormones. This results in a downsizing of the networks of brain cell connections.
  3. Sugar toxicity – damages via:
    1. advanced glycation end products (AGEs) acting to damage through inflammation as well as,
    2. loss of cell supports because of shoddy insulin signaling necessary for healthy brain activity.
  4. A protective response by amyloid that bind to things that the brain perceives as a toxin – things like: copper, iron, mercury, biotoxins, infections.
  5. People in their 50s and early 60s tend to have the more “toxic” form.
  6. Problems with blood vessels and leakiness in the protective blood-brain-barrier which result in lower support chemicals and toxicity.
  7. Trauma, e.g., from things like concussions – which also lower chemical and hormone support as well as make the brain susceptible to all the insults mentioned above.

The story of “Patient Zero” (Minute 28:53)
Dr. Bredesen describes the first success he had with his program.

Things that induce Alzheimer’s a.k.a. “Dementogens”

  • Biotoxins
    • Exposures to water building and the harmful effects of mold
    • Tick exposures
  • Heavy Metals Exposure
    • Aluminum, copper, mercury
  • Water damaged building, mycotoxins
  • Certain types of infections
  • Concussions
  • The effects of diabetes and poor diet
  • Certain types of pollution
  • Not enough time asleep or insufficient oxygen when you sleep.\
  • Not enough exercise

Elements of a “Cognoscopy”
Because the brain changes in Alzheimer’s can creep in 20 years or more before symptoms start prevention makes a whole lot of sense. Though a cognoscopy doesn’t really exist yet in a conventional medical setting, Dr. Bredesen’s thinks that one should probably be done around age 45 to assess the risk of developing Alzheimer’s and might include the following:

  1. Genetic markers and blood work that elucidates Dr. Bredesen’s three metabolic subtypes (see an MPICognitions.com to find a doctor trained in the protocol).
  2. Functional cognitive testing using BrainHQ, Lumosity, Cog-state, CNS vital signs to see where your brain function is in a “testing environment”.
  3. Brain MRI with volumetrics (listen to Evolving Past Alzheimer’s podcast with Dr. Cyrus Raji episode #6 for full explanation) if someone has symptoms.

The Role of Sleep in Alzheimer’s

  • Time of repair (don’t eat 3 hours before bed)
  • Time for autophagy (brain cell “pruning”)
  • There is a slight change in the microanatomy of the brain where some of the accumulated toxicants get “washed away”
  • Sleep hygiene is important

Who typically improves with the Bredesen Program?
Dr. Bredesen mentions the “MoCA” which refers to the Montreal Cognitive Assessment. This is a screening test that won’t tell you if someone has Alzheimer’s but can give you a general indication of different levels of cognitive impairment.  Dr. Bredesen mentioned that people that score 22 or greater (out of 30) are seeing improvements with his methodology.  These are people that are typically early on in their disease.

Who typically does not improve with the Bredesen Program?

  • People that are more “frail” (less able to exercise, etc.)
  • People that are further along with the disease and have had symptoms for longer periods of time.

How much improvement do people see with the Bredesen Program?
Some people seem to get just a bit better in terms of mood, outlook, and brain function. Others get much better and almost completely back to their best brain function. Too early to say how many, but more than half of the people using the methodology report some sort of improvement.

A discussion of an upcoming Documentary of the impact on people’s lives using Dr. Bredesen’s program.