Episode 502: Prozac (Fluoxetine) and Other Drugs That Injure Endothelium
Heart Doc VIP with Dr. Joel Kahn
Release Date: 06/30/2026
Episode 509: How to Upgrade Your Gene Activity in 4 Weeks
Heart Doc VIP with Dr. Joel Kahn
This week, Dr. Kahn discusses new research showing that after just 4 weeks of eating a whole-food, plant-based diet, sophisticated measures of gene activity demonstrate a reversal in aging and a reduction in inflammation. In another study, the calorie advantage of a plant-based diet is discussed, with the equation H=N/C (Health = Nutrition/Calories) proving to be a useful reminder. Finally, athletic performance in college athletes eating plant-based or omnivore diets was equivalent, which is reassuring to many. Dr. Kahn and his wife will begin their 50th year of plant-based diets in September....
info_outline
Episode 508: Why Cooking to Reduce AGE Content Is a Healthy Habit
Heart Doc VIP with Dr. Joel Kahn
This week, Dr. Kahn discussed new research on advanced glycation end-products (AGEs) and cooking methods. High levels of AGEs promote many disease states and can be avoided with water-based cooking methods like steaming, boiling, and pressure cooking. Other topics include visceral fat loss and brain health, bitter hops extract for weight loss, the Planetary Health Diet, fructose in the diet and cancer growth, a failed study on inflammation, and the role of multivitamins in cardiac health. Thanks to the Fresh Pressed Olive Oil Club and the $1 offer at .
info_outline
Episode 507: The Nuance of How Much Dietary Protein for Optimal Health
Heart Doc VIP with Dr. Joel Kahn
This week, Dr. Kahn discusses new data from the amazing Valter Longo, PhD, and his colleagues regarding optimizing diet for both longevity and strong muscles. In a new publication, Dr. Longo used mouse models to show that animals fed a Longevity Diet, as described in his book, lived longer. However, when moderate amounts of methionine, an amino acid, were included in the diet, frailty was avoided. He then analyzed a dataset of 200,000 health professionals in the United States and found that those consuming the highest amounts of animal protein had double the risk of type 2 diabetes, as well as...
info_outline
Episode 506: Advanced Cardiac Lab Testing With Dr. Ivan Rusilko
Heart Doc VIP with Dr. Joel Kahn
In this bonus episode, Dr. Kahn interviews functional medicine specialist Ivan Rusilko about the importance of advanced lab panels. Together, they explore the full spectrum of cardiac lab testing, with a special focus on inflammation, insulin resistance, and how these markers can uncover hidden cardiovascular risk. If you are a health care practitioner, set up an account at . Mention the Heart Doc VIP Podcast when creating your new practitioner account to receive 50% off CardioPro™ Advanced Diagnostic Panels, providing unparalleled insights into patient health.
info_outline
Episode 505: A Breakthrough in Cholesterol Care With an Oral PCSK9 Inhibitor
Heart Doc VIP with Dr. Joel Kahn
This week, Dr. Kahn discusses the FDA approval of the first oral PCSK9 inhibitor, Lipfendra (enclicitide), taken as a 20 mg daily tablet. In a study of nearly 3,000 patients with elevated LDL cholesterol despite treatment with statins and, in many cases, ezetimibe, LDL-C dropped by more than 50% while Lipoprotein(a) levels fell by 28%, with an excellent safety profile. The medication is expected to retail for approximately $315 per month and will be available in pharmacies soon. A larger outcomes trial evaluating its impact on heart attack and stroke rates is currently underway. Other topics...
info_outline
Episode 504: Why Inflammation Matters for Patients with Lp(a)
Heart Doc VIP with Dr. Joel Kahn
This week, Dr. Joel Kahn explores important new research showing how elevated inflammation, measured by Interleukin-6 (IL-6), may dramatically increase cardiovascular risk in people with high Lipoprotein(a), or Lp(a). He explains why IL-6 is emerging as an important biomarker and reviews the other inflammation tests he routinely uses at the Kahn Center, including hs-CRP, MPO, Lp-PLA2, NT-proBNP, fibrinogen, ferritin, the sedimentation rate, and the white blood cell count. Dr. Kahn also discusses Lilly's newly approved oral weight loss medication, the ABCDEF framework for cardiovascular...
info_outline
Episode 503: Supplements to Reverse Atherosclerosis: Follow-Up to The Proof
Heart Doc VIP with Dr. Joel Kahn
Dr. Joel Kahn explores the latest science on supplements that may help slow or reverse atherosclerosis, building on a recent discussion from Simon Hill's The Proof podcast. He takes a closer look at the evidence behind vitamin K2, niacin, pycnogenol with centella asiatica, beta-cyclodextrin, and bergamot, explaining where the research is strongest and what it could mean for heart health. Additional topics include new research on nutrient deficiencies to watch for in vegan diets, the potential kidney risks of certain calcium channel blockers, the health benefits of onions, advanced plaque...
info_outline
Episode 502: Prozac (Fluoxetine) and Other Drugs That Injure Endothelium
Heart Doc VIP with Dr. Joel Kahn
This week, Dr. Kahn reviews important new research showing that the commonly prescribed antidepressant Prozac (fluoxetine) may disrupt cholesterol metabolism, injure the endothelium (the delicate lining of arteries), and potentially increase cardiovascular risk. He also examines growing evidence linking proton pump inhibitors (PPIs) and several common cancer therapies to endothelial damage, emphasizing that patients should always discuss the risks and benefits of these medications with their healthcare team rather than stopping treatment on their own. Other topics include new Harvard research...
info_outline
Episode 501: The Surprising Science of Gratitude and Heart Health
Heart Doc VIP with Dr. Joel Kahn
Can a simple gratitude practice improve your heart health? This week, Dr. Kahn explores the growing science linking gratitude to better well-being, improved sleep, lower inflammation, and even enhanced cardiac function. He shares his own gratitude practices and offers practical ways to incorporate them into daily life. Also covered in this episode: how adherence to Life's Essential 8 is associated with longevity, even among the ultra-elderly; the importance of identifying cholesterol hyperabsorbers; the connection between obesity and cancer risk; the relationship between sleep apnea and...
info_outline
Episode 500: The Long Path to Building an Integrative Cardiology Practice
Heart Doc VIP with Dr. Joel Kahn
In this special 500th episode of Heart Doc VIP, Dr. Joel Kahn reflects on the personal and professional journey that shaped his 36-year career in cardiology and preventive medicine. From his childhood in Detroit and medical training at the University of Michigan to founding the Kahn Center for Cardiac Longevity, Dr. Kahn shares the mentors, experiences, and lessons that influenced his approach to patient care. He also reviews new research on heart disease mortality in the United States, vitamin K2 and coronary artery calcium progression, plant-based diets for chronic kidney disease, factors...
info_outlineThis week, Dr. Kahn reviews important new research showing that the commonly prescribed antidepressant Prozac (fluoxetine) may disrupt cholesterol metabolism, injure the endothelium (the delicate lining of arteries), and potentially increase cardiovascular risk. He also examines growing evidence linking proton pump inhibitors (PPIs) and several common cancer therapies to endothelial damage, emphasizing that patients should always discuss the risks and benefits of these medications with their healthcare team rather than stopping treatment on their own.
Other topics include new Harvard research showing that combining aerobic exercise, strength training, and less time spent watching television can reduce the risk of type 2 diabetes by up to 60%; promising data on niacin for glioblastoma brain cancer; predicting statin-related muscle injury; the protective effects of plant-based diets against heart disease, dementia, and several cancers; tea consumption and lower cardiovascular risk; vitamin K-rich leafy greens and lung health; whole grains and breast cancer prevention; and the latest research on red meat, inflammatory bowel disease, and hypertension.
Thanks to igennus.com/drkahn for this week's podcast sponsorship featuring their vegan Super B Complex.