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520: S-Equol - The Natural Estrogen Support System Most Women Abandoned for No Reason with Dr. Siobhan Mitchell

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Release Date: 04/24/2026

538: Fat Loss in Midlife - What the Last 20 Years Has Taught Me show art 538: Fat Loss in Midlife - What the Last 20 Years Has Taught Me

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Join us for a LIVE interactive fat loss workshop to continue this conversation:   What if everything you were taught about losing weight in your 20s and 30s is actually working against you now? I've spent almost 20 years coaching midlife women through fat loss, and I've lived every bit of it myself, ten years of perimenopause, post-menopause, injuries, autoimmune issues, and all. Today I'm done watching the internet sell midlife women quick fixes that were never built for our bodies. I'm laying out the five pillars I've seen actually work, in the order they matter, and the why behind each...

info_outline 537: You Can Eat Perfectly Clean and Still Be Mineral Deficient - Here's Why with Caroline Alan show art 537: You Can Eat Perfectly Clean and Still Be Mineral Deficient - Here's Why with Caroline Alan

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

You guys know I am a HUGE believer in the right supplements and the right protocols. So when I tell you that today's episode is about the FOUNDATION underneath ALL of it, lean in. Modern scientists believe we are operating at only thirty-seven to forty percent of the mineral levels our bodies actually need. Minerals are the only nutrient class your body cannot make. They are the foundation under hormones, gut, sleep, energy, hair, and yes, even under the great supplements you are already taking. This is the conversation midlife women have been waiting for. I sat down with Caroline Alan,...

info_outline 536: What's Actually Happening to Your Nervous System When You Feel 536: What's Actually Happening to Your Nervous System When You Feel "Off"

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

In this episode I share something I never thought I would talk about on this microphone: quantum physics. Not the wellness version. The actual physics. The kind that won the 2022 Nobel Prize. I walk you through why some of us feel things in our bodies that other people do not, why midlife makes us more sensitive (not less), how quantum entanglement actually works in plain English, and what happened when I flew to Germany and got my brain measured in a high-density EEG lab. The data is on paper. The lab is real. The results are mine. And I think every midlife woman who has ever been told she is...

info_outline 535: How to Stop People-Pleasing and Start Living in Midlife with Star Monroe show art 535: How to Stop People-Pleasing and Start Living in Midlife with Star Monroe

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

What if the thing you've been calling a midlife crisis is actually the most important reckoning of your life? In this episode, Natalie sits down with Star Monroe, a self-identity expert and somatic psychotherapist who helps midlife women face the crisis underneath the crisis, the version of themselves they abandoned decades ago just to feel safe, loved, and chosen. Star opens up about her own unfiltered history, including addiction, two marriages, financial collapse, and the moment she finally understood that her self-destructive patterns were never about the substance itself. They were about...

info_outline 534: Why You're Still Deficient After Taking All the Right Supplements (The Absorption Problem Gets Worse in Midlife) with Lindsey Burwell show art 534: Why You're Still Deficient After Taking All the Right Supplements (The Absorption Problem Gets Worse in Midlife) with Lindsey Burwell

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Tired of choking down pills and wondering if any of it is showing up? Transdermal could be the answer. The Patch Method bypasses our digestion and liver completely. Super easy, just slap it on. Code NATALIEJILL for 20% off at  PLUS… DM "NatalieJill" to @the.patchmethod on Instagram and the first 50 people will receive a free patch kit of their choice plus four free samples. What if the drawer full of supplements you have been faithfully taking every morning is actually making your liver work harder without making you feel any better? If you have ever walked out of a functional medicine...

info_outline 533: Biohacking Gone Wrong: Why Everything You're Doing to Optimize Your Health Might Be Backfiring with Dr. Sabrina Solt show art 533: Biohacking Gone Wrong: Why Everything You're Doing to Optimize Your Health Might Be Backfiring with Dr. Sabrina Solt

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

What if the supplements you've been taking to feel better are actually the reason you feel worse? That's exactly what happened to me, and it sent me down a rabbit hole that led to one of the most important conversations I've had about my own health. Today I'm sitting down with my close friend and personal doctor, Dr. Sabrina Solt, a regenerative medicine physician and peptide expert who has been in this field for over a decade. We start with the question that started everything for me: why was I wired at 3am, crashing every afternoon, and reacting to the exact supplements I thought were...

info_outline 532: The ONE Biohack That Works Regardless of Your Genetics with Kashif Khan show art 532: The ONE Biohack That Works Regardless of Your Genetics with Kashif Khan

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Don't miss the free live hydrogen workshop with Kashif. Save your seat at   What if every biohack you've tried has been missing the one piece that actually makes it work? Red light, peptides, cold plunges, NAD, wellness IVs. You've tried some of them. Some worked. Some didn't. And here's the maddening part: your friend is thriving on the same protocol that made you feel worse. That's not random, and you're not broken. There's a reason, and it's rooted in your unique biology in ways most practitioners never explain. In this episode, I sit down with Kashif Khan, founder of The DNA Company...

info_outline 531: Europe Changed My Health (Here's the Science): What We Tested, What we learned, and What We Can't Stop Thinking About show art 531: Europe Changed My Health (Here's the Science): What We Tested, What we learned, and What We Can't Stop Thinking About

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

If you have ever come back from Europe and thought, why do I feel BETTER over there, this episode is for you. Natalie and her husband Brooks just got back from one of the most incredible trips of their lives. Germany, Switzerland, Lake Como, Piedmont, Lake Lucerne, Basel and Heidelberg. And it was not just beautiful. It rearranged some things in their bodies that they want to break down for you. In this conversation we go through every stop on the route, why pasta in Italy feels different than bread in the US, why dairy in Europe digests so much better, the hormone shift Natalie had to make...

info_outline 530: The Bacteria in Your Mouth Is Linked to Heart Disease, Anxiety, and Hormonal Chaos with Dr. Pedram Shojai show art 530: The Bacteria in Your Mouth Is Linked to Heart Disease, Anxiety, and Hormonal Chaos with Dr. Pedram Shojai

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Get the oral biome test we talked about in the show at  This is the conversation I have been waiting to have. If you are doing the breathwork, the meditation, the supplements, the protocols, and you are STILL feeling anxious, inflamed, bloated, and exhausted, this episode will explain why. My guest is Dr. Pedram Shojai, The Urban Monk. He is a New York Times bestselling author and a Doctor of Oriental Medicine, and the man who first came on this show talking about stress and the nervous system. Years later, after a wild full-circle moment in a group coaching call, we are back together to...

info_outline 529: The EU Banned 1,300 Skincare Ingredients. The U.S. Banned 11. Here's What You Need to Know with Brian Vaszily show art 529: The EU Banned 1,300 Skincare Ingredients. The U.S. Banned 11. Here's What You Need to Know with Brian Vaszily

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Special offer for Midlife Conversations listeners: for up to 38% off - a special savings of $5 off each bottle of Dream Cream purchased and is the lowest savings you will find.  If you have ever turned a "clean" skincare bottle around, read the back, and not been able to pronounce a single ingredient, this episode is for you. The European Union has banned over 1,300 ingredients from skincare. The United States has banned 11. ELEVEN. So what are we actually putting on our faces every single day? And in midlife, when our hormones are already in flux, what are those ingredients doing to...

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More Episodes

What if the belly fat, the exhaustion, and the 3 a.m. wake-ups were never about willpower or effort at all?

In this episode, Dr. Siobhan Mitchell, a neuroscientist with 25 years of nutrition and cellular health research behind her, breaks down exactly what is happening inside the body during midlife and why the same habits that worked at 35 stop working at 45. Dr. Mitchell is currently the Chief Science Officer at MitoQ, a cellular health company with over $60 million in research, and she brings a level of scientific depth to this conversation that is genuinely rare.

What unfolds is not the standard hormone health conversation. Dr. Mitchell explains the critical difference between the two estrogen receptor types, why visceral belly fat is actually a metabolic warning sign and not just a cosmetic frustration, and the truth behind decades of fear-mongering around soy. She also introduces a compound called S-equol that most women have never heard of, despite research showing it may outperform soy isoflavones for menopausal symptoms, joint pain, blood sugar, bone density, and brain health. The catch? Only 20 to 30 percent of Western women can produce it naturally, and the rest need to approach it differently.

The conversation goes deeper into mitochondria, aging, oxidative stress, and why protecting your cellular energy production may be one of the most important things you can do in midlife. Natalie also opens up about her own experience with cortisol, soy, and the mom guilt she carried for 18 years over a decision she now knows was completely fine.

This one is packed. Whether you are on HRT, avoiding it, or somewhere in the middle, there is something in this episode that will change how you understand your own body.

Learn More About Dr. Siobhan Mitchell

Instagram ➜ https://www.instagram.com/mitoq  

Website ➜ Visit https://www.mitoq.com  and use code NATALIEJILL to save

 

Thank you to our show sponsors: 

  • TIMELINE: Timeline is offering 20% off your order of Mitopure! Go to https://timeline.com/NATALIEJILL 

  • COZY EARTH: Discover how Cozy Earth turns everyday routines into moments of softness and ease. Head to https://cozyearth.com/ and use my code NATALIEJILL for an exclusive 20% off



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Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen. 

Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.