LDL, Insulin Resistance and The Real Cause of Heart Disease | Dr. Anthony Jay
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
Release Date: 08/10/2026
Psychedelic Therapy in 2026: The New Frontier of Treating Addiction and Trauma, and What's Coming First | Bryan Hubbard, Americans for Ibogaine
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
Apply to work with a Muscle Intelligence Coach → W. Bryan Hubbard is the CEO of Americans for Ibogaine, the organization he co-founded with former Texas Governor Rick Perry, and the reason ibogaine is now inside an FDA drug development pathway. He is also a conservative Kentucky attorney who once believed anyone holding a psychedelic belonged under the jail. What changed his mind was a single Scientific American article about psilocybin and alcohol dependency, a family history with alcohol, and a decade running two of Kentucky's largest government systems while the opioid epidemic that...
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How to Focus, Recover and Lead Better by Working With Your Brain's Wiring | Wharton Neuroscientist Dr. Michael Platt
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
Want help designing your training, nutrition, and recovery around the way your body and brain actually work? Apply to work with the Muscle Intelligence coaching team → Wharton neuroscientist Dr. Michael Platt has spent his career studying how the brain makes decisions, why high performers burn through their attention, and what actually improves brain health and brain performance in people with real demands on their time. In this conversation with Ben Pakulski, he explains why the human brain is still running on wiring built for a world of small groups, constant movement, and natural...
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The Molecule Behind Blood Flow, Energy, and Sexual Health After 40 | Dr. Nathan Bryan
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
Work with a Muscle Intelligence Coach: Dr. Nathan Bryan has spent 25 years researching nitric oxide, the gas your body produces to open blood vessels and move oxygen into every cell you have. In this conversation he explains why production drops roughly 10 to 12 percent per decade, why a man in his forties is often operating on half of what he had, and what that decline shows up as first. Ben and Dr. Bryan cover the symptom hierarchy of nitric oxide deficiency, why sexual function is the earliest signal and what it says about the rest of the arterial system, why 50 percent of men...
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The Complete Peptide Guide for Brain, Mitochondria and Growth Hormone Support
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
If you're interested in peptides I have some resources for you → Apply to work with the MI team → Ryan Smith co-founded the first pharmacy in the United States to offer an extensive list of peptides — and he ran the synthesis floor himself. Preparative HPLC, mass spec, chemical synthesis, the lot. Which means he spent years watching the same two failures from the inside: the molecule that works beautifully at a small dose and stops working when someone doubles it, and the vial that looks identical to the real thing and isn't. He is not a peptide evangelist. Ask him about the compound...
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The Simple Mechanism Behind Long-Term Performance
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
Most men trying to change their body are shopping for a tactic. A cleaner diet, a better split, a smarter supplement stack, and lately a peptide protocol they found online. Ben has coached enough high performers to know how that story ends, because he lived a version of it himself. He was an obese fifteen-year-old who decided he was going to compete at the Mr. Olympia, and the obsessive, run-through-the-wall identity that got him there is the same one he had to dismantle at forty-five when it started costing him at home and failing to keep pace with what his life actually demanded. This...
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LDL, Insulin Resistance and The Real Cause of Heart Disease | Dr. Anthony Jay
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
This episode is sponsored by Super Patch: Apply for Muscle Intelligence Coaching: You cleaned up your diet, cut the carbs, and your LDL went up. Your doctor circled it in red and reached for a statin. Dr. Anthony Jay spent five years doing heart disease research full time at Boston University Medical School — running autopsies, removing plaque from human arteries, publishing on oxidized LDL — and for most of that time he was a statin guy himself. His mentor took them and bragged about it. His textbooks put the men who invented them on a pedestal. Then he kept looking at what was...
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Why Your Testosterone Labs Come Back Normal While You Feel Terrible | Dr. Abraham Morgentaler
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
Work with the Muscle Intelligence Team: Most men who suspect their testosterone is low get a blood test, get told the number is normal, and get sent home still exhausted, still soft in the middle, still wondering what happened to the guy they used to be. Dr. Abraham Morgentaler has spent thirty-five years proving that those men are not imagining it. He is a urologist on the Harvard Medical School faculty, the physician who overturned the belief that testosterone causes prostate cancer, and the author of Testosterone for Life and The Truth About Men and Sex. He was treating low testosterone...
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The Daily Routine That Keeps Your Body Moving Well For Life
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
Get first access to my 21-day mobility series (first 100 signups free) → Apply to work with the MI team → Most men accept stiffness, tight hips, and creaky shoulders as just part of getting older. Ben says that's backwards — and in this solo episode, he breaks down why. He covers why mobility has almost nothing to do with stretching (it's about keeping the fascia hydrated through movement), why your rib cage and spine — not your shoulder — are usually the real reason your shoulder hurts, and why skipping squats and deadlifts quietly caps how much upper-body muscle you can build. He...
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The Harvard Case That Aging Follows Your Mind | Dr. Ellen Langer
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
Book your free Transformation Call → The story you believe about aging isn't just a mindset — it's a biological input. Dr. Ellen Langer, the first woman ever tenured in psychology at Harvard (at 31) and author of The Mindful Body, has spent 50 years running experiments that sound impossible until you see the data: hotel housekeepers who lost real weight after a single 10-minute conversation, wounds that healed at the speed of a rigged clock, and elderly men who came out of a 5-day experiment with measurably better memory, strength, hearing, and vision. Ben sits down with the...
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A Stoic Psychotherapist on the Inner Game of Powerful Men | Donald Robertson
Muscle Intelligence — Longevity, Training & Human Performance with Ben Pakulski
Want to work with Muscle Intelligence? Most men try to out-discipline their emotions and wonder why they still snap, freeze, or stew at the worst possible moment. Donald Robertson, the cognitive-behavioral psychotherapist who wrote the book on thinking like a Roman emperor, has spent three decades proving there's a better operating system. Drawing on the same Stoic playbook that ran an empire, he and Ben discuss why composure isn't suppression, why the calmest man in the room is almost never the one trying hardest to stay calm, and where the real leverage hides inside every reaction you...
info_outlineThis episode is sponsored by Super Patch: https://bit.ly/misuperpatch
Apply for Muscle Intelligence Coaching: https://muscleintelligence.com/apply
You cleaned up your diet, cut the carbs, and your LDL went up. Your doctor circled it in red and reached for a statin. Dr. Anthony Jay spent five years doing heart disease research full time at Boston University Medical School — running autopsies, removing plaque from human arteries, publishing on oxidized LDL — and for most of that time he was a statin guy himself. His mentor took them and bragged about it. His textbooks put the men who invented them on a pedestal. Then he kept looking at what was actually inside the plaque, and at what the endpoint studies actually measured, and he changed his mind. He is the author of Estrogeneration and the new book Sugar Beat, and he runs a DNA consulting practice doing four consults a day.
In this conversation he walks through the 28,000-person study that ranks insulin resistance more than five times higher than LDL as a risk for an early heart attack, explains what LDL is actually built to do in the body, and traces the fifty-year sequence in which the target moved from total cholesterol to LDL to particle number to particle size to ApoB — each time, he argues, right as a new drug became available. He lays out the mechanism he believes builds plaque in the first place, why your heart is designed to run on fat and what happens when you train it on sugar instead, and which markers he thinks are actually damaging the artery wall while nobody tests for them. Ben pushes back the whole way, with his own father and with a client whose LDL sits above 800. If your labs came back red and nobody explained what was actually measured, start here.
KEY TAKEAWAYS
- The risk factor that outranked LDL by more than four to one in a 28,000-person study of real heart attacks, not blood markers
- What LDL is actually for, and why getting healthier can raise it by design
- The $40 scan he ran on himself that told him more than twenty years of cholesterol readings ever did
- Why he argues that lowering the number can leave you with more arterial calcification rather than less
- The genetic quirk he has never discussed publicly that makes olive oil and avocado a real problem for a surprising number of people
CONNECT WITH DR. JAY
Website – https://www.ajconsultingcompany.com
DNA Analysis & Consults – https://www.ajconsultingcompany.com/dna.html
YouTube – https://www.youtube.com/anthonyjaycast
Instagram – https://www.instagram.com/anthonygjay
Book – Sugar Beat: How Sugar, Not Cholesterol, Destroys Your Arteries
Book – Estrogeneration: How Estrogenics Are Making You Fat, Sick, and Infertile