Why Your Diet Isn't Working - And Why It Might Be Your DNA
Release Date: 02/23/2026
Red Face After One Drink? It's Your Genes (And Why Coffee Keeps You Up)
Pushing The Limits
Why can one person drink a flat white at 3pm and sleep soundly, while another lies awake until midnight? Why does one glass of wine turn some people bright red? A lot of it comes down to your genes. In this solo episode, I break down the caffeine and alcohol genes I look at in my clients' myDNA reports, what your results can and can't tell you, and the simple changes that follow. In this episode: - How CYP1A2 shapes how long caffeine hangs around, and why your cut-off time matters - What the research shows about caffeine, genetics and athletic performance - ADORA2A, and why some people feel...
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The One Test That Never Expires: Why Your DNA Is the Most Important Thing You'll Ever Test
Pushing The Limits
I ran 70,000km across the world's toughest deserts to lose weight, and I got heavier, more inflamed and sicker every year. I assumed the problem was discipline. It took one genetic test to show me it never was. In this solo episode I make the case that your DNA is the single most valuable test you will ever do. Not because it tells you the most, but because it is the only test whose result is still true in fifty years. Your bloods reflect the last few weeks. Your microbiome shifts with every trip and every course of antibiotics. Your hormones move across the month and the decade. Your DNA does...
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Your Immune System Is Aging Faster Than You Are
Pushing The Limits
Your Immune Age Is Lying To You. Here's How To Read Your Blood And Fix It. How old is your immune system, really? It's probably not the same age as you are — and that gap may be the single biggest hidden driver of how well you age, how fast you recover, and how long you stay healthy. In this episode I break down what actually happens to your immune system as the years tick over — immunosenescence (the immune system getting weaker) and inflammaging (the silent, smouldering inflammation that never switches off) — and why almost every disease of ageing sits somewhere on that spectrum. Then...
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Professor Julia Rucklidge: Micronutrients, Mental Health and Why the RDAs Are Broken
Pushing The Limits
The link between micronutrients and mental health is one of the most overlooked stories in modern medicine, and Professor Julia Rucklidge has spent more than two decades proving it matters. In this episode of Pushing the Limits, she shares the research on micronutrients and mental health that has challenged psychiatry's drug-first model, showing that broad-spectrum vitamins and minerals can treat ADHD, depression and anxiety, often as effectively as medication and without the side effects. If you have ever wondered how deeply micronutrients and mental health are connected, this conversation...
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R3HBG: The Bioidentical Ketone That Bypasses the Liver | Mike Chesne, Tecton Founder
Pushing The Limits
What if there was an exogenous ketone that didn't go through the liver, didn't cause the GI distress of other ketones, and delivered bioidentical BHB directly to your cells? In this episode, Lisa sits down with Mike Chesne, founder of Tecton and retired US Army Special Forces combat medic, who spent 25 years in special operations before developing R3HBG — a patented ketone molecule that's categorically different from everything else on the market. Mike's journey from battlefield medicine to biotech is extraordinary. After suffering multiple traumatic brain injuries from IED blasts during...
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INUSpheresis: Removing Toxins, Heavy Metals & Microplastics From Blood/ Tash Simons
Pushing The Limits
What if the reason you're not getting better isn't about what you're putting in — but what you can't get out? In this episode I sit down with Tash Simons from INUSpheresis Perth — the first clinic in Australia and the Southern Hemisphere to offer this advanced blood filtration therapy. We go deep into how double filtration plasmapheresis works, the two specialised filters (TKM58 and INUS 30), and the science behind removing autoantibodies, inflammatory cytokines, heavy metals, microplastics, PCBs, and oxidised LDL directly from your blood — without involving your kidneys or liver. We...
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Copper, Mitochondria Grey Hair & Autism: The Missing Link No One Is Talking About
Pushing The Limits
Could a simple mineral deficiency be driving mitochondrial dysfunction in autism? In this episode I sit down with Melissa Atchley from MitoSynergy to hear her personal story of using BioCopper1 with her son on the autism spectrum — and the changes she saw that no one expected. I break down the science behind it: Dr Richard Frye's research showing Complex IV dysfunction in children with ASD, the brand new April 2026 Science Advances paper linking copper deficiency directly to ASD-like behaviours through mitochondrial damage and impaired myelination, and why the type of copper matters — Cu1+...
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Klotho, Peptides & Limitless Longevity — Dr. Alex Grinberg & Dr. Dave Jenkins
Pushing The Limits
These two doctors are building a clinic where the most advanced longevity therapies have no limits. Dr. Alexander Grinberg (Infinity Epigenetics, San Francisco) and Dr. Dave Jenkins (Bredesen-trained, 40+ years clinical experience) are combining peptide therapy, regenerative medicine, and personalised protocols at a level most people don't know exists. From Klotho protein restoring cognitive function in head injury patients to mitochondrial peptides that can rescue dying cells — this conversation covers the cutting edge of what's actually possible right now. About the Guests Dr. Alexander...
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The 7 Reasons Your Cells Age (And How to Stop It) Dr Sandra Kaufmann
Pushing The Limits
Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. 👉 FREE Longevity Cheat Sheet — subscribe to my weekly newsletter: Description: Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Dr Sandra Kaufmann is a cell biologist, physician, and creator of the Kaufmann Protocol — the first comprehensive rating system for anti-aging supplements. In this episode...
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The One System Behind ALL 14 Hallmarks of Aging — And How to Target It | Courtney Van Bussum
Pushing The Limits
Your immune system isn't just fighting off colds. It's the foundational system that influences all 14 hallmarks of aging — and when it declines, everything downstream accelerates. In this episode, I sit down with Courtney Van Bussum, COO of Longevity Launch Labs, to dive deep into immunosenescence — the aging of the immune system — and why it starts far earlier than most people realise. We unpack what Stanford's landmark 1000 Immunomes Project revealed about the real driver of biological aging, why your supplement stack might be missing the most important piece, and how we built...
info_outlineWhat if the diet you've been following diligently — eating all the right things, tracking your macros, staying committed — is actually wrong for your specific biology?
In this solo episode I share the anonymised case of a real client who gained eight kilograms following a ketogenic diet perfectly. Not because she was doing it wrong. Because her genetics made her one of the worst possible candidates for high saturated fat eating — and nobody had ever looked at her DNA.
We go deep on the three specific genetic variants that predicted her poor response to keto, what her full microbiome mapping revealed that standard testing would have completely missed, and how her hormonal picture and chronic stress were silently driving the whole metabolic picture.
This episode is for anyone who has tried hard, followed the advice, and still isn't getting results. It's time to stop blaming yourself and start looking at your biology.
We cover why Instagram diet advice is genuinely dangerous for people with different genetics, what comprehensive functional testing actually looks like — DNA panels, microbiome mapping, DUTCH hormone testing, detailed bloodwork — and the universal dietary principles that apply to almost everyone regardless of their genetic profile.
Your body is not broken. It just needs the right instructions.
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and try Rejuvenate Pro — our flagship Immune and gut health/longevity supplement — at https://shop.lisatamati.com/pages/rejuvenate
Discover your immune age at myimmuneage.life
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