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Why Would Vitamin C cause muscle pain, joint pain, and brain fog? | Masterjohn Q&A Files #326

Release Date: 10/23/2023

Mastering Nutrition

For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to contractile failure, fatigue, and delayed-onset muscle soreness. Some people still believe this. You may have heard the argument against it from well-known figures like Andy Galpin, or, if you’re deep into the science, you may have read the work of George Brooks. In this lesson, we are going to cover the biochemistry of lactate production. We will see that we never make lactic acid, ever. We make lactate. Making lactate is fundamentally...

D-Lactate: Groundbreaking Research No One Is Talking About

Mastering Nutrition

D-lactate is commonly stated to be exclusively a microbial metabolite. This is found in assumptions within the medical literature for decades even when it was long-known to be false. While D-lactate is indeed made by bacteria, D-lactate is also inarguably and irrefutably produced by human enzymes. In this podcast, moreover, I will argue the following: Microbial contribution to D-lactate in humans under normal circumstances is negligible. I coin the term “the D-lactate shuttle” to describe a role for D-lactate that should eventually make its way into biochemistry textbooks...

Handling Creatine Side Effects

Mastering Nutrition

In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of asthma, bloody noses, anxiety, headaches, heart palpitations, twitching, and fast or slow heartbeat. The full podcast and article can be found here:

Your Cells Are Starving For Creatine

Mastering Nutrition

Creatine is like your second mitochondria. Or, the mitochondria’s chief of staff. Or its co-pilot. Your mitochondria make ATP so you can see clearly, hear accurately, digest your food, power your brain, show off your your shiny skin, lift heavy things, and perform your best at the challenges you face. They do that all with the help of creatine. Creatine is responsible for spreading the impact of mitochondrial ATP production into the general area of the cell known as the cytosol, and into every organelle outside the mitochondria. While it is more important in cells with high ATP...

Is Whole Food Vitamin C Really Different? | Masterjohn Q&A Files #330

Mastering Nutrition

Question: Is whole food vitamin C superior to natural because it is part of a tyrosinase complex? Short Answer: Vitamin C is nearly ubiquitously distributed in plant tissues, and is never bound to any enzyme as a structural complex. Vitamin C promotes absorption of iron from plant foods, inhibits copper absorption, and de-loads copper from ceruloplasmin, which may play a role in distributing copper to tissues. Vitamin C is not capable of destroying ceruloplasmin. These functions follow directly from vitamin C as an electron donor and there is no evidence whatsoever that whole food vitamin C...

What's the Deal With Seed Oils? | Masterjohn Q&A Files #329

Mastering Nutrition

Question: What Is the Real Issue With Seed Oils? Short Answer: The main issue with seed oils is that they present an oxidative liability. They do not acutely cause oxidative stress, but their polyunsaturated fatty acids (PUFAs) are more vulnerable than any other macronutrient to oxidative damage. Oxidative stress can increase because of nutrient deficiencies, toxins, infections, other sources of inflammation, alcohol, or smoking, and it will inevitably increase as a function of aging. As oxidative stress increases, more PUFAs in the tissues mean more damage. At least 0.6 milligrams of vitamin...

Is Hair Mineral Testing Useful? | Masterjohn Q&A Files #328

Mastering Nutrition

Question: How useful is hair trace mineral analysis (HTMA) for nutritional testing? Short Answer: Hair trace mineral analysis is included as an optional add-on in the comprehensive nutritional screening from Testing Nutritional Status: The Ultimate Cheat Sheet, because it can capture data for some ultra-trace minerals for which there are no better-validated tests, and it might capture a pattern that might not be picked up as quickly with blood work, such as a mineral transport issue. However, its utility is limited by the fact that hair mineral content is not well validated as a test for any...

Secrets to Superior Cognitive Performance (Without Drugs)

Mastering Nutrition

Nutrition is far more powerful than drugs to improve cognitive performance. We start by looking at cocaine, Adderall, and Ritalin, and show why these drugs cannot possibly hold a candle to nutrition. Optimal nutrition can definitely optimize the function of dopamine, norepinephrine, acetylcholine, histamine, creatine, and the methylation system, and in doing so can simultaneously optimize focus, motivation, sustained attention, and mental flexibility, and methylation, all while eliminating anxiety, depression, and distraction. Yet, popular nutritional cognitive stacks in the nootropic space do...

Vitamin C, Whole Food Vs. Synthetic: Does It Matter?

Mastering Nutrition

Debunking the myth that vitamin C in plants is found in a special "tyrosinase complex." For the written article with references, see here: For issues of vitamin C dosing and balancing with other nutrients, see these two links:

Fact-Checking Gary Brecka on Rogan: A Deep Dive into MTHFR and Methylation

Mastering Nutrition

Watch or listen to the full critique here: https://www.youtube.com/watch?v=kMPvCiOkEtQ

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Question: Why Would Vitamin C cause muscle pain, joint pain, and brain fog?

Short Answer: Acutely, vitamin C would likely cause these effects by generating oxalate, which could cause crystals that lead to muscle and joint pain, and could cut energy metabolism in half, leading to brain fog. This vulnerability could result from deficiencies of any of the B vitamins, any of the electrolytes, or of iron, copper, or sulfur; from diabetes, low adrenals, or hypothyroidism; or from any of the hundreds of genetic defects in energy metabolism, only one of which is glucose 6-phosphate dehydrogenase deficiency; or any one of a huge number of toxins that impair energy metabolism. Chronically, vitamin C may increase the harms of iron overload or contribute to copper deficiency. The main ways to manage these latter issues are to take vitamin C away from meals, to maintain good copper status through proper dietary intake, and to treat iron overload with phlebotomy.

This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:

https://chrismasterjohnphd.substack.com/p/questions-on-nac-biofilms-vitamin

In that batch of free episodes you will also find the answer to this question:

Can NAC hurt your gut health?
How to Find the Root Cause of Autoimmunity?

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up:

https://chrismasterjohnphd.substack.com/qanda

Learn more about the Masterpass here:

https://chrismasterjohnphd.substack.com/about

This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

GLA to lower hydroxyhaemopyrrolin-2-one?
When would I use the StrateGene and Genova Methylation Panel for nutritional testing?
Energy metabolism as a root cause of gut issues?
Nutrition for skin healing?
Nutrition for hypnic jerks?
Suggestions for snoring or sleep apnea?
Nutrition to protect against restaurant meals?
What is the cause of crusty eyes in the morning?
What causes brain fog?
How much oxalate should one eat each day?
Should I be concerned about low alkaline phosphatase?
What nutrients give tall children to short parents?
Energy metabolism impairment mimicking Wilson's disease.
Can taking digestive enzymes reduce our own production?
Rapid-fire response to non-winners from the question contest.

Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-may

Access the show notes, transcript, and comments here.

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