Depression Starts In Your Mitochondria
Mastering Nutrition
You could be one metabolic bottleneck away from feeling amazing. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease. Find it at mito.me This is not medical advice and is for educational purposes only. Chris Masterjohn, PhD, is the Founder and Scientific Director of the .
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Aging is best explained by declining mitochondrial function over time.
Mastering Nutrition
Aging is best explained by declining mitochondrial function over time. This answers its own “why.” Mitochondria produce the energy needed for repair so if any of it gets lost it sets up a vicious cycle. And some *always* gets lost. But how much is under your control. From Joe Rogan Experience JRE 2420. It’s a vicious cycle initiated by the second law of thermodynamics which requires a constant input of energy to prevent the collapse of order. Hence, there will always be slippage, but how much slippage depends on...
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The Medical Myth That Nutritional Deficiencies Are A Thing of the Past
Mastering Nutrition
This is a clip from Joe Rogan Experience JRE 2420. Watch the full interview here: Chris Masterjohn, PhD, is the Founder and Scientific Director of the .
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Why Doctors Think They Can Ignore the Studies Suggesting Seed Oils Cause Heart Disease
Mastering Nutrition
This is a clip from Joe Rogan Experience JRE 2420. Watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0
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The Problem With Seed Oils and Why They Are So Controversial
Mastering Nutrition
This is a clip from Joe Rogan Experience Episode 2420. You can watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0
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Mitochondria: Why They Control Everything in Human Health
Mastering Nutrition
Mitochondria govern everything. Watch this with the slides here: https://www.youtube.com/watch?v=mED1_L3wZbc Mitochondria convert your food to usable energy in the form of ATP, which is used to produce, maintain, repair, distribute, and organize everything in your body. Abundant health right now, and preserving your health throughout the lifespan toward your longevity, all depends on your mitochondria. In fact the best explanation for aging is that its a vicious cycle of declining mitochondrial function. We should always be thinking of mitochondria first. SSRIs, acne treatments, and statins...
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SSRI Withdrawal Is Mitochondrial Dysfunction
Mastering Nutrition
Chris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americans and about 5-10% of the world's population are on SSRIs, which have become the first-line treatment of depression. These can cause sexual dysfunction and emotional blunting in up to half of people, an unclear incidence of sleep disruption, and a rare risk of suicidality, self-harm, and new-onset psychosis. On the other hand, 20-50% of people who go off experience SSRI...
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How Lactate Alkalinizes Your Muscles
Mastering Nutrition
For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to contractile failure, fatigue, and delayed-onset muscle soreness. Some people still believe this. You may have heard the argument against it from well-known figures like Andy Galpin, or, if you’re deep into the science, you may have read the work of George Brooks. In this lesson, we are going to cover the biochemistry of lactate production. We will see that we never make lactic acid, ever. We make lactate. Making lactate is fundamentally...
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D-Lactate: Groundbreaking Research No One Is Talking About
Mastering Nutrition
D-lactate is commonly stated to be exclusively a microbial metabolite. This is found in assumptions within the medical literature for decades even when it was long-known to be false. While D-lactate is indeed made by bacteria, D-lactate is also inarguably and irrefutably produced by human enzymes. In this podcast, moreover, I will argue the following: Microbial contribution to D-lactate in humans under normal circumstances is negligible. I coin the term “the D-lactate shuttle” to describe a role for D-lactate that should eventually make its way into biochemistry textbooks...
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Handling Creatine Side Effects
Mastering Nutrition
In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of asthma, bloody noses, anxiety, headaches, heart palpitations, twitching, and fast or slow heartbeat. The full podcast and article can be found here: Chris Masterjohn, PhD, is the Founder and Scientific Director of the .
info_outlineChris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it.
This is not medical advice, diagnosis, or treatment.
29 million Americans and about 5-10% of the world's population are on SSRIs, which have become the first-line treatment of depression.
These can cause sexual dysfunction and emotional blunting in up to half of people, an unclear incidence of sleep disruption, and a rare risk of suicidality, self-harm, and new-onset psychosis.
On the other hand, 20-50% of people who go off experience SSRI discontinuation syndrome.
This can involve irritability, anxiety, mood problems, crying, dread, suicidal ideation, insomnia, nightmares, excessive dreaming, lethargy, fatigue, headache, tremor, sweating, anorexia, flu-like symptoms, nausea, vomiting, diarrhea, pain, numbness, tingling, feeling like something is crawling on the skin, electric shocks running through the brain or body, rushing noises, visual traces (seeing something persist when it is no longer there, or seeing moving objects leaving illusory streaks of light behind them, etc), dizziness, light-headedness, "brain zaps," vertigo, confusion, difficulty concentrating, amnesia, genital hypersensitivity, and premature ejaculation.
A closely related problem is post-SSRI sexual dysfunction (PSSD), which can cause total inability to feel the penis for males or for females the genitals and nipples, loss of sexual pleasure, weak orgasms, decreased libido, erectile dysfunction, and premature ejaculation. PSSD is often associated with general anhedonia, apathy, and poor mood.
In this video, Masterjohn maintains that the reason there are no good solutions to these problems is because we have completely misunderstood the role of serotonin and SSRIs.
Serotonin's role is to help mitochondria adapt to changing demands for oxygen-based energy production.
SSRIs enhance some of the mechanisms, and interfere with others. They enter the cell and stimulate independent mechanisms of mitochondrial stress adaptation, but in doing so they turn a cyclical and rhythmic pathway into a constantly stimulated one, creating mitochondrial dependence and making mitochondria vulnerable to new-onset dysfunction upon withdrawal. Once they make it to the mitochondria itself, the SSRIs act as mitochondrial toxins.
Scientific references for everything covered in the video can be found in this series:
https://chrismasterjohnphd.substack.com/p/prozac-is-a-performance-enhancing
At the bottom of each article is a link to the next one.
0:30 SSRI Side Effects
1:00 SSRI Discontinuation Syndrome and PSSD
11:33 The Problem With Primary Care Doctors and Psychiatrists
14:56 The Reason We Don’t Have Good Solutions Is Because We Don’t Understand the Problem
16:22 Prozac Is a Performance-Enhancing Drug
18:40 Depression and Altitude
19:36 The Truth About Serotonin
25:10 How Serotonin Helps Us Breathe
30:05 Hypoxia Explains Why Serotonin Is So Abundant In the Gut
33:55 Serotonin, Melatonin, and the Mitochondria
35:50 Serotonin and Light
39:25 Intermittent Hypobaric Hypoxia Training
42:56 SSRIs Are Whole-Body, Primarily Non-Brain, Non-Neuronal, Mitochondrial Drugs
44:00 SSRIs and Birth Defects
46:37 SSRIs Deplete Serotonin
48:50 SSRIs Distort the Sigma-1 Receptor From a Cyclical to a Constant Activation
51:10 Different SSRIs Promote Different Ratios of Mitophagy and Mitochondrial Biogenesis
54:00 Going Off SSRIs Causes New-Onset Mitochondrial Dysfunction
58:30 Slow and Hyperbolic Tapers
1:02:10 What to Do About SSRI Withdrawal Mitochondrial Dysfunction
Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondrial test Mitome.
Do You Have Hidden Mitochondrial Dysfunction?
Mitochondrial dysfunction is one of the earliest signs of aging and chronic disease—and most people don’t know they have it. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease.
Find it here at mito.me