D-Lactate: Groundbreaking Research No One Is Talking About
Release Date: 07/31/2024
Depression Starts In Your Mitochondria
Mastering Nutrition
You could be one metabolic bottleneck away from feeling amazing. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease. Find it at mito.me This is not medical advice and is for educational purposes only. Chris Masterjohn, PhD, is the Founder and Scientific Director of the .
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Aging is best explained by declining mitochondrial function over time.
Mastering Nutrition
Aging is best explained by declining mitochondrial function over time. This answers its own “why.” Mitochondria produce the energy needed for repair so if any of it gets lost it sets up a vicious cycle. And some *always* gets lost. But how much is under your control. From Joe Rogan Experience JRE 2420. It’s a vicious cycle initiated by the second law of thermodynamics which requires a constant input of energy to prevent the collapse of order. Hence, there will always be slippage, but how much slippage depends on...
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The Medical Myth That Nutritional Deficiencies Are A Thing of the Past
Mastering Nutrition
This is a clip from Joe Rogan Experience JRE 2420. Watch the full interview here: Chris Masterjohn, PhD, is the Founder and Scientific Director of the .
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Why Doctors Think They Can Ignore the Studies Suggesting Seed Oils Cause Heart Disease
Mastering Nutrition
This is a clip from Joe Rogan Experience JRE 2420. Watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0
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The Problem With Seed Oils and Why They Are So Controversial
Mastering Nutrition
This is a clip from Joe Rogan Experience Episode 2420. You can watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0
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Mitochondria: Why They Control Everything in Human Health
Mastering Nutrition
Mitochondria govern everything. Watch this with the slides here: https://www.youtube.com/watch?v=mED1_L3wZbc Mitochondria convert your food to usable energy in the form of ATP, which is used to produce, maintain, repair, distribute, and organize everything in your body. Abundant health right now, and preserving your health throughout the lifespan toward your longevity, all depends on your mitochondria. In fact the best explanation for aging is that its a vicious cycle of declining mitochondrial function. We should always be thinking of mitochondria first. SSRIs, acne treatments, and statins...
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SSRI Withdrawal Is Mitochondrial Dysfunction
Mastering Nutrition
Chris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americans and about 5-10% of the world's population are on SSRIs, which have become the first-line treatment of depression. These can cause sexual dysfunction and emotional blunting in up to half of people, an unclear incidence of sleep disruption, and a rare risk of suicidality, self-harm, and new-onset psychosis. On the other hand, 20-50% of people who go off experience SSRI...
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How Lactate Alkalinizes Your Muscles
Mastering Nutrition
For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to contractile failure, fatigue, and delayed-onset muscle soreness. Some people still believe this. You may have heard the argument against it from well-known figures like Andy Galpin, or, if you’re deep into the science, you may have read the work of George Brooks. In this lesson, we are going to cover the biochemistry of lactate production. We will see that we never make lactic acid, ever. We make lactate. Making lactate is fundamentally...
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D-Lactate: Groundbreaking Research No One Is Talking About
Mastering Nutrition
D-lactate is commonly stated to be exclusively a microbial metabolite. This is found in assumptions within the medical literature for decades even when it was long-known to be false. While D-lactate is indeed made by bacteria, D-lactate is also inarguably and irrefutably produced by human enzymes. In this podcast, moreover, I will argue the following: Microbial contribution to D-lactate in humans under normal circumstances is negligible. I coin the term “the D-lactate shuttle” to describe a role for D-lactate that should eventually make its way into biochemistry textbooks...
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Handling Creatine Side Effects
Mastering Nutrition
In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of asthma, bloody noses, anxiety, headaches, heart palpitations, twitching, and fast or slow heartbeat. The full podcast and article can be found here: Chris Masterjohn, PhD, is the Founder and Scientific Director of the .
info_outlineD-lactate is commonly stated to be exclusively a microbial metabolite.
This is found in assumptions within the medical literature for decades even when it was long-known to be false.
While D-lactate is indeed made by bacteria, D-lactate is also inarguably and irrefutably produced by human enzymes.
In this podcast, moreover, I will argue the following:
Microbial contribution to D-lactate in humans under normal circumstances is negligible.
I coin the term “the D-lactate shuttle” to describe a role for D-lactate that should eventually make its way into biochemistry textbooks alongside the malate-aspartate shuttle and the glycerol phosphate shuttle.
The D-lactate shuttle operates alongside these other shuttles to balance the priorities of conserving cytosolic NAD+, reducing cytosolic acidity, bypassing complex I, or generating ATP. It is uniquely useful as a shuttle when there is an absolute deficit of niacin or NAD(H).
D-lactate is an important contributor to gluconeogenesis that could account for up to 11% of it and rival an individual amino acid.
While D-lactate concentrations in human plasma are infinitesimal, when the downstream metabolism of D-lactate and L-lactate are blocked by genetic disorders, the concentrations of the two forms are similar in plasma. This contrasts wildly with the common claim that flux through D-lactate is “minuscule.” Most likely D-lactate is produced in considerable quantities in liver and kidney but is rarely secreted into plasma because doing so would risk neurotoxicity.
D-lactate should be taken seriously for its potential role in Parkinson’s and in neurological problems generally, for its role in diabetes, and for its extremely underappreciated roles in glycolysis, gluconeogenesis, and the respiratory chain.
Oxalate powerfully impairs D-lactate clearance, so D-lactate should be investigated as a potential link between oxalate and autism, and oxalate-lowering strategies should be seen as a way to improve D-lactate clearance and reduce its potential role in diabetes and neurological disorders.
See the sections on riboflavin, zinc manganese, and glutathione in Testing Nutritional Status: The Ultimate Cheat Sheet, as well as Does CoQ10 Deserve a Spot on Your Longevity Plan? and the How to Detox Manganese guide for managing the relevant nutrients.
Read the written version for live links and references:
https://chrismasterjohnphd.substack.com/p/d-lactate-groundbreaking-research
Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.