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Episode 204: How The Microbiome Impacts Your health, Immune System, and Thyroid Physiology

Thyroid Answers Podcast

Release Date: 08/12/2025

Episode 206: Rebooting Your Thyroid Physiology with Dr. Justin Marchegiani show art Episode 206: Rebooting Your Thyroid Physiology with Dr. Justin Marchegiani

Thyroid Answers Podcast

In episode 206 of the Thyroid Answers Podcast, I interview Dr. Justin Marchegiani regarding his newly released book, The Thyroid Reboot. Topics covered in this episode include: Why is The Thyroid Reboot book different than others? What is driving thyroiditis and hypothyroidism? Is hypothyroidism caused by an immune system out of control or an adaptive response? The impact of stressors on driving thyroiditis and hypothyroidism Starting points for addressing hypothyroidism The role of thyroid antibodies And more... Dr. Justin Marchegiani began his medical career at the University of...

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TS Episode 12: The Real Reason Your Thyroid Medication Isn't Working show art TS Episode 12: The Real Reason Your Thyroid Medication Isn't Working

Thyroid Answers Podcast

If you're taking thyroid medication but still struggling with fatigue, brain fog, and weight gain despite "perfect" lab results, this episode will change everything. Dr. Eric Balcavage reveals why millions of thyroid patients are stuck in "Thyroid Purgatory" - where labs look optimal but symptoms persist - and introduces the groundbreaking concept of cellular hypothyroidism that explains why your cells may be rejecting the thyroid hormones you're taking.   Discover why the Cell Danger Response acts like a cellular security system, blocking thyroid hormone utilization even when blood...

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Episode 205: Understanding Thyroid Labs: What Your Doctor Might Be Missing show art Episode 205: Understanding Thyroid Labs: What Your Doctor Might Be Missing

Thyroid Answers Podcast

In episode 205 of the Thyroid Answers Podcast, Dr. Kelly Halderman returns to discuss Thyroid labs and what your doctor might be missing. In this episode, we cover: Why TSH run by itself can be a misleading test Why both total and free hormones should be run, but often aren't Understanding T3 Uptake Reverse T3: what it is and why it is improtant Thyroid antibodies: the reality behind their presence And more... If you struggle with chronic hypothyroid symptoms despite what you have been told is appropriate or "optimized" Thyroid Hormone Replacement, you must listen to this episode. The...

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Thyroid Shorts 11:  FDA Removal of Dessicated Thyroid Extracts - Why this may not be a bad thing show art Thyroid Shorts 11: FDA Removal of Dessicated Thyroid Extracts - Why this may not be a bad thing

Thyroid Answers Podcast

In this episode, Dr. Eric Balcavage discusses the recent announcement by the FDA to remove dessicated thyroid extracts from the market.   Key Topics Covered: Why this may not be a bad thing. Alternatives to DTE  Why DTE prescriptions can be a slippery slope. Why DTE prescriptions may keep you stuck in thyroid purgatory Why DTE prescription may be contributing to your hypo and hyperthyroid symptoms. And more...

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Episode 204: How The Microbiome Impacts Your health, Immune System, and Thyroid Physiology show art Episode 204: How The Microbiome Impacts Your health, Immune System, and Thyroid Physiology

Thyroid Answers Podcast

Join Dr. Eric Balcavage as he explores the critical relationship between gut health and thyroid function with registered dietitian and microbiome expert Kara Siedman. This episode dives deep into how your microbiome - the collection of bacteria, fungi, and viruses living in your gut - directly impacts thyroid physiology and overall health.   Kara breaks down the complex science into actionable insights, explaining how gut dysbiosis can trigger thyroid dysfunction through inflammatory pathways, intestinal permeability, and disrupted hormone conversion. You'll discover why digestive...

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Thyroid Shorts Episode 10:  Does the Cell Danger Response Apply to Everyone? show art Thyroid Shorts Episode 10: Does the Cell Danger Response Apply to Everyone?

Thyroid Answers Podcast

In this episode, Dr. Eric Balcavage responds to a thoughtful viewer comment that challenges key aspects of his adaptive thyroid physiology model and Cell Danger Response theory. This deep-dive discussion addresses whether his approach applies to every hypothyroidism case, clarifies the 71% improvement statistic, and explores the role of T3 therapy in thyroid treatment.   Key Topics Covered: Does the Cell Danger Response theory apply to all hypothyroidism cases? Clarification of the 71% patient improvement statistic - what it really means Historical use of NDT (Natural Desiccated...

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Episode 203: The Gut-Thyroid Connection: How Your Microbiome Impacts Your Metabolism show art Episode 203: The Gut-Thyroid Connection: How Your Microbiome Impacts Your Metabolism

Thyroid Answers Podcast

In this episode of Thyroid Answers, Dr. Eric Balcavage sits down with functional health coach Anu Simh to explore the critical connection between gut health, thyroid function, and overall metabolism.   What You'll Learn: Why normal TSH doesn't mean optimal thyroid function - and what's really happening at the cellular level  How chronic stress disrupts your gut microbiome and creates a cascade of health issues  The difference between homeostasis and allostatic regulation - and why understanding this changes everything  Why gut protocols often fail long-term (and what's...

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Episode 202: Missing Strategies That May Ignite Your Weight Loss show art Episode 202: Missing Strategies That May Ignite Your Weight Loss

Thyroid Answers Podcast

Dr. Eric Balcavage interviews Nagina Abdullah about why traditional weight loss approaches fail for women with thyroid issues, especially in midlife. Nagina shares her personal journey from yo-yo dieting to losing 40 pounds using metabolism-focused strategies and reveals the framework she's used to help 1600+ women.   Key Topics Covered: Why "calories in, calories out" doesn't work in midlife How perimenopause changes metabolism and increases inflammation  The role of stress, sleep, and under-eating in weight gain  Nagina's "Tested & Perfected Fat Burning Food...

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Episode 201: Radiopharmaceutical Therapy & Theranostics: A New Frontier in Thyroid and Cancer Care show art Episode 201: Radiopharmaceutical Therapy & Theranostics: A New Frontier in Thyroid and Cancer Care

Thyroid Answers Podcast

Join Dr. Eric Balcavage as he explores the cutting-edge world of nuclear medicine with Dr. Munir Ghesani, Chief Medical Officer at United Theranostics. Discover how theranostics—the fusion of diagnostics and therapeutics—is revolutionizing cancer treatment, particularly for thyroid conditions. Key Topics Covered: The fascinating history of nuclear medicine, born from thyroid treatment in the 1940s How radioactive iodine therapy works and why it's so effective for thyroid cancer The difference between traditional treatment and modern theranostic approaches Revolutionary redifferentiation...

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Thyroid Shorts Episode 9:  Thyroid Conversion Problems Explained show art Thyroid Shorts Episode 9: Thyroid Conversion Problems Explained

Thyroid Answers Podcast

In this in-depth episode of Thyroid Shorts, Dr. Eric Balcavage addresses one of the most misunderstood aspects of thyroid physiology: T4 to T3 conversion problems.   What You'll Learn: Why conventional medicine ignores conversion issues and focuses only on TSH The critical difference between "broken" physiology vs. adaptive responses How deiodinase enzymes (D1, D2, D3) actually control thyroid hormone conversion Why your body might be intentionally reducing T4 to T3 conversion The real reasons behind elevated reverse T3 levels Why T3 medication often backfires and creates more problems...

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More Episodes
Join Dr. Eric Balcavage as he explores the critical relationship between gut health and thyroid function with registered dietitian and microbiome expert Kara Siedman. This episode dives deep into how your microbiome - the collection of bacteria, fungi, and viruses living in your gut - directly impacts thyroid physiology and overall health.
 
Kara breaks down the complex science into actionable insights, explaining how gut dysbiosis can trigger thyroid dysfunction through inflammatory pathways, intestinal permeability, and disrupted hormone conversion. You'll discover why digestive symptoms aren't always present even when gut dysfunction is driving thyroid issues, and learn practical strategies for supporting your microbiome through diet, lifestyle, and targeted interventions.
 
Key topics include:
  • The role of short-chain fatty acids,
  • The truth about probiotic supplementation
  • How to evaluate microbiome health
  • The connection between GLP-1 production and metabolic function.

Whether you're dealing with Hashimoto's, hypothyroidism, or other chronic conditions, this episode provides the foundational knowledge you need to understand why gut health is often the missing piece in thyroid recovery.

Kara Siedman, RDN, CDCES is a registered dietitian and certified diabetes care and education specialist with over 15 years of clinical experience in inpatient care, outpatient program development, and integrative/functional nutrition. She earned her degree from the University of Massachusetts Amherst and completed her dietetic internship at Cal Poly San Luis Obispo.

Kara’s work in a leading gastroenterology practice sparked her transition into functional nutrition, where she integrated root-cause approaches into GI care and became a mentor and key opinion leader in the field. Her passion for the gut microbiome evolved into a professional specialty, leading her to collaborate with biotech and microbiome-focused companies like Pendulum, Microbiome Labs, and now Resbiotic. As Director of Partnerships at resbiotic, Kara educates healthcare providers on microbiome science and the clinical application of targeted microbiome therapies. Known for her ability to simplify complex research, she brings clarity, credibility, and passion to gut health education.

https://resbiotic.com/