LONGEVITY with Nathalie Niddam

LONGEVITY with Nathalie Niddam is your go-to podcast for diving deep into the science and practices for increasing your longevity and healthspan. This podcast covers topics from nutrition, biohacking, longevity, peptides, bioregulators, cutting edge research, health technology and more! Nathalie Niddam is a certified nutritionist, as well as a epigenetics and human potential coach.

#410: Reversing Burnout: Turmeric, Gut Health, and Circadian Rhythms Explained With Shivani Gupta 02/06/2026

#410: Reversing Burnout: Turmeric, Gut Health, and Circadian Rhythms Explained With Shivani Gupta Today, I’m joined by the wonderful Dr. Shivani Gupta, a true force in bridging ancient Ayurvedic wisdom with cutting-edge modern research on inflammation and healthy aging. She recently authored The Inflammation Code. Dr. Shivani opens up about her deeply personal motivation—from witnessing her grandfather’s preventable health decline to spending years in both traditional and scientific studies, ultimately earning a PhD focused on turmeric and chronic inflammation. For Dr. Shivani’s Turmeric and sleep gummies visit and use code NAT15 for 15% off. Episode Timestamps: Welcome & Introduction to Longevity Podcast ... 00:00:00 Autophagy & Spermidine Supplementation ... 00:02:41 Personal Connection & Product Experience ... 00:03:46 Health Declines in Modern Indian Culture ... 00:07:47 Reversing Disease: Ayurveda & Biohacking ... 00:11:11 Discovering Ayurveda & Turmeric’s Power ... 00:15:12 Turmeric vs. NSAIDs: Scientific Support ... 00:19:52 PPIs, Gut Health, and Curcumin ... 00:21:26 Inflammation as the Root of Chronic Disease ... 00:23:24 Sleep Rituals & Circadian Timing ... 00:28:59 Elemental Design / Doshas Explained ... 00:32:13 Aligning Lifestyle with Dosha for Health ... 00:42:46 Mental Inflammation: Stress & Burnout ... 00:46:00 Turmeric Science, Uses & Myths ... 00:54:20 Personalized Spice Use & Dosha Guidance ... 01:03:48 Top Spices for Longevity ... 01:07:44 Cautions: Medications & Turmeric ... 01:10:03 The Future of Inflammation in Medicine ... 01:11:11 Rapid-Fire Longevity Habits ... 01:15:03 Our Amazing Sponsors: by LVLUP Health - supports your liver’s natural detox pathways so your body can reset without suffering. Go to and use code NAT for 20% off. — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit and use code BIONAT20 at checkout. — A powerful duo of a clinically proven probiotic and digestive bitters to reduce bloat, boost energy, curb cravings, and help you feel your best fast, backed by a 100% money-back guarantee — Take the Feel Better Challenge and save 20% at with promo code NAT20. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39860885

#409: How to LIVE YOUNG for a Lifetime: The Real Secrets of Mindset, Medicine & Longevity | Personalized Health Explained With Dr. Jeffrey Gladden 02/03/2026

#409: How to LIVE YOUNG for a Lifetime: The Real Secrets of Mindset, Medicine & Longevity | Personalized Health Explained With Dr. Jeffrey Gladden Today, I’m joined by the inspiring —a trailblazer in longevity medicine who once spent decades as an interventional cardiologist, only to challenge everything he knew after his own health hit a wall. Dr. Gladden opens up about the moment he refused to accept “normal for your age” as a diagnosis, launching himself into the world of functional and age-management medicine to reclaim his vitality and help others do the same. Episode Timestamps: Welcome and episode introduction ... 00:00:00 Health crisis and discovering personal optimization ... 00:07:05 From “sick care” to health optimization ... 00:10:46 Vision for personalized, youthful longevity ... 00:12:17 Personalized medicine: why one size doesn’t fit all ... 00:16:00 Linear versus exponential aging; fixing a flawed approach ... 00:18:02 Five circles of exponential health: key longevity domains ... 00:19:23 Curiosity, growth mindset, and quantum thinking in longevity ... 00:22:22 Why individualization is crucial for diet and interventions ... 00:28:52 Insulin resistance: the hidden driver of aging ... 00:33:41 Environmental and internal (psychospiritual) factors in health ... 00:38:40 Healing through meditation, stress management, and flow ... 00:41:15 Robustness, resilience, and anti-fragility as longevity superpowers ... 00:57:09 Safe, personalized hormone therapy and the importance of tracking ... 01:03:33 Integrating mindset, purpose, and psycho-spiritual work ... 01:08:50 Peptides and advanced therapies: preparing for optimal results ... 01:09:56 Common test misconceptions in longevity medicine ... 01:12:56 Debunking the myth of single biological age ... 01:16:38 Resources, connect with Dr. Gladden, and closing ... 01:18:09 Our Amazing Sponsors: by Young Goose — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours at and use code Nat10 for first orders or 5NAT for returning customers. - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it’s easy to try for yourself. Visit and use code NAT10 to start the free trial. Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to for 20% off Mitopure®️ Gummies. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39838295

#408: The Surprising Truth About Metabolomics, Stress, and Slowing Aging (Peptides, Heavy Metals & Foundational Health Secrets) With Gus Vickery 01/30/2026

#408: The Surprising Truth About Metabolomics, Stress, and Slowing Aging (Peptides, Heavy Metals & Foundational Health Secrets) With Gus Vickery Today, I’m sitting down with , a good friend and one of my favorite collaborators when it comes to cutting-edge insights in personalized health and longevity. In this episode, I put myself under the microscope as we walk through my own metabolomics testing after a period of heavy travel, stress, and—yes—a break from my usual supplement routine. If you’ve ever wondered whether skipping your foundational health habits “just for a little while” really matters, you’re about to find out. If you are a clinician and would like to offer the Aristotle test to your patients please use this link to learn more about the Theriome test: If you are a patient and would like to run the Theriome Aristotle test and get a full interpretation and protocol based on your results from Dr Vickery & his team please use this link: Episode Timestamps: Introduction to Longevity Podcast and episode overview ... 00:00:00 Metabolomics and interpreting health data – practitioner guidance needed ... 00:05:05 Combining metabolomics, gut, and blood data for whole-system insights ... 00:06:02 Nutrient depletion and oxidative stress: critical findings ... 00:18:57 Supplementation essentials for aging well ... 00:27:05 Metabolomics comparison by age group and optimization goals ... 00:29:03 Stacking interventions: why less is more with diagnostics ... 00:31:05 Functional health markers and the value of context ... 00:34:47 Sympathetic dominance, mindset, and impact on longevity ... 00:35:26 Restoring nervous system balance – inner work and tech tools ... 00:42:38 Toxins, heavy metals, and practical detox strategies ... 00:49:11 Clean environment, resiliency, and realistic lifestyle shifts ... 00:55:29 Key nutrient deficiencies revealed by metabolomics ... 01:09:15 Genetic and metabolomic tests: what’s actionable? ... 01:15:07 Hope for the future: human resilience and expanding technology ... 01:22:24 Weekly actionable: walk outside for mitochondria and stress relief ... 01:26:55 Our Amazing Sponsors: – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at with code LONGEVITY for up to 20% off, and don’t forget to mention this podcast in the post-purchase survey. - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to and use code NAT15 for 15% off your first order. from Young Goose brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, “Hey, start making that collagen again!” It’s longevity science, not cosmetic hype. Visit —use code NAT10 to get started, or 5NAT if you’re an existing customer. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39827550

#407: How MUSCLE Changes Everything: The Secret Organ of Longevity | Why “Healthy Sedentary” Is a Myth (and What To Do Instead) With Dr. Gabrielle Lyon 01/27/2026

#407: How MUSCLE Changes Everything: The Secret Organ of Longevity | Why “Healthy Sedentary” Is a Myth (and What To Do Instead) With Dr. Gabrielle Lyon Today, I’m joined by the remarkable , a pioneer in redefining the longevity conversation by making muscle health—not weight—the centerpiece of aging well. With a background in geriatrics and nutritional sciences, she illuminates why the quality of your muscle tissue is a far more powerful predictor of health than any number on the scale. Her perspective challenges the notion of a “healthy sedentary person” and reveals the major role of intramuscular fat in metabolic dysfunction. Check out her book . Episode Timestamps: Introduction, podcast focus, and welcoming Dr. Gabrielle Lyon ... 00:00:00 Muscle's impact on brain health, inflammation, and healthy aging ... 00:01:03 Dr. Lyon's childhood, grit, and self-discipline ... 00:04:33 Mentorship and protein science under Dr. Donald Lehman ... 00:07:05 Muscle as the overlooked metabolic organ ... 00:08:45 Why intramuscular fat matters more than body weight ... 00:10:06 Plant vs. animal protein for muscle health ... 00:13:29 Muscle as an endocrine organ and cognition ... 00:16:21 Future of muscle science: anabolics, imaging, and technology ... 00:18:22 GLP-1s, sarcopenic obesity, and muscle-first protocol ... 00:46:45 Sarcopenia, aging, and the importance of early training ... 01:04:35 Building lifelong resilience—mental and physical ... 01:08:31 Predictions: anabolics, muscle testing, and assessment ... 01:12:17 "Strength is a responsibility, not a luxury" ... 01:13:53 Our Amazing Sponsors: – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at with code LONGEVITY for up to 20% off, and don’t forget to mention this podcast in the post-purchase survey. - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to and use code NAT to get $75 off. by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It’s not a knockout pill; it’s a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit and use code NAT15 for 15% off. Sleep smarter, not harder. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39731770

#406: Peptide OVERLOAD: When Biohacking Backfires (How NOT to Crash Your Mitochondria) With Anthony Castore 01/23/2026

#406: Peptide OVERLOAD: When Biohacking Backfires (How NOT to Crash Your Mitochondria) With Anthony Castore Today, I’m joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators. Use code NAT10 for 10% off products at Episode Timestamps: Welcome and episode introduction ... 00:00:00 Anthony Castore’s path from strength coaching to cellular medicine ... 00:05:55 Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27 Explaining and balancing AMPK and mTOR for performance ... 00:13:03 Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18 Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04 Assessing recovery capacity and individualizing protocols ... 00:26:02 Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57 Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00 Differentiating bodybuilder vs. longevity approaches ... 00:34:44 Integrating peptides and support molecules into routines ... 00:40:44 Ketone esters and mitochondrial peptide interventions ... 00:41:20 Cautions on stacking and combining interventions ... 00:54:04 Lessons learned from overdoing interventions ... 01:05:02 Our Amazing Sponsors: - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit and use code NAT20 for 20% off. - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at with code NAT20. by LVLUP Health - supports your liver’s natural detox pathways so your body can reset after the holidays without suffering. Go to and use code NAT for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39733090

#405: Heart Attacks Aren’t What You Think | The Plaque LIE That Changes Everything (Cardiology 2.0) With Dr. Sanjay Bhojraj 01/20/2026

#405: Heart Attacks Aren’t What You Think | The Plaque LIE That Changes Everything (Cardiology 2.0) With Dr. Sanjay Bhojraj Today, I’m joined by the deeply thoughtful and refreshingly honest , a self-described “curious cardiologist” who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it? Episode Timestamps: Welcome to Longevity & episode setup … 00:00:00 Dr. Bhojraj’s shift from ER cardiology to prevention … 00:06:30 Why most heart attacks aren’t caused by big blockages … 00:09:15 Stress, nervous system load & heart attack risk … 00:13:10 CIMT explained: what it measures (and what it misses) … 00:26:40 Calcium scores vs CT angiograms … 00:35:45 CLEERLY scan: seeing dangerous soft plaque … 00:38:45 Can plaque actually regress? … 00:41:55 When heart scans make patients less afraid … 00:44:05 When should you test — even without symptoms? … 00:45:50 Why age 45 is a major cardiovascular inflection point … 00:47:10 Hormones, estrogen loss & women’s heart risk … 00:50:10 Why cardiology still misunderstands women … 00:54:30 Small dense LDL, ApoB & oxidized cholesterol … 01:02:00 Why fixing inflammation matters more than numbers … 01:05:50 Our Amazing Sponsors: - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it’s not just “healthy aging” in theory. Go to and use code NAT25 to save 25% are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. Get 35% off a one-month subscription at *Special deal through January 2026. — A clean, high-quality whey protein that’s third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to and use code NAT for 32% off your first subscription or 20% off anything on the site. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39627925

#404: The Dirty Truth About Your Home’s WATER (And Why Most Filters Including Reverse Osmosis Don’t Cut It) With Charles Bohdy and Victor Sagalovsky 01/16/2026

#404: The Dirty Truth About Your Home’s WATER (And Why Most Filters Including Reverse Osmosis Don’t Cut It) With Charles Bohdy and Victor Sagalovsky Today, I’m joined by , a true innovator in , and Victor Sagalovsky, a passionate advocate for bringing the science of water quality into our daily lives. Together, we take a deep dive into the unseen world of the water running through our homes—exploring not just its purity, but its hidden potential to support our biology in ways most of us have never considered. - Use code NAT100 Episode Timestamps: Intro to Longevity Podcast and today’s water focus ... 00:00:00 Water system’s health benefits and testing ... 00:01:33 Why water quality is overlooked yet critical ... 00:07:20 Common water issues and municipal limitations ... 00:09:10 Filtration methods: carbon blocks and pathogens ... 00:15:26 Charles’s nano-ceramic multilayer filters ... 00:20:14 Concerns with chlorine and fluoride in water ... 00:23:44 Retaining healthy minerals: charge-based filtration ... 00:35:18 Reverse osmosis: pros, cons, and fungal risks ... 00:50:49 Structured water’s role in biological health ... 00:56:53 Water structuring: agricultural validation ... 01:00:21 Whole-home filtration: installation and costs ... 01:11:02 Closing thoughts: bringing nature’s water home ... 01:25:00 Our Amazing Sponsors: - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it’s not just “healthy aging” in theory. Go to and use code NAT25 to save 25% by Oxford Healthspan: Primeadine supports autophagy — your cells’ natural renewal and cleanup process — using food-derived spermidine, no fasting required. If you want to support resilience from the inside out, head to and use code BIONAT20 at checkout (one-time purchases only). - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to and use code NAT to get $75 off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39575155

#403: What’s REALLY In Your Food? | Dark Secrets of Ultra-Pasteurized Milk, Natural Flavors & Microplastics EXPOSED With Ben Katz 01/13/2026

#403: What’s REALLY In Your Food? | Dark Secrets of Ultra-Pasteurized Milk, Natural Flavors & Microplastics EXPOSED With Ben Katz Today, I’m joined by Ben Katz—better known online as —an academic analytical chemist from UC Irvine whose mission is to uncover what’s really in our everyday foods, drinks, and products. Ben reverse engineers everything from Taco Bell meat to Doritos, and sometimes even entire industries, using cutting-edge mass spectrometry. His curiosity and expertise have made him a go-to source for those wanting to know what’s hiding behind vague ingredient labels and “natural flavors.” Episode Timestamps: Welcome and podcast introduction ... 00:00:00 What is mass spectrometry? ... 00:05:00 Viral "what’s in it?" projects and public interest ... 00:07:27 Synthetic vs. plant-derived nicotine and toxins in plant extracts ... 00:09:53 Food label transparency and loopholes (natural flavors, FEMA, GRAS) ... 00:20:11 Sweeteners & artificial additives: sucralose, stevia, cost motivations ... 00:23:07 Ultra pasteurization of milk and added flavors ... 00:29:48 Chocolate, caffeine content, and labeling challenges ... 00:33:12 Industrial food processes, GMOs, and food security insights ... 00:38:36 Microplastics: occurrence, regulation, and PEG in food ... 00:50:15 Supplements under development for microplastic removal ... 00:58:43 Adulteration in olive oil, maple syrup, and honey ... 01:04:08 Hidden sweeteners, and processed food pitfalls ... 01:10:14 Avoid artificial sweeteners, problematic plastics, and hidden flavors ... 01:14:36 Our Amazing Sponsors: - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to to save up to 31% plus $25 in free gifts with the Starter Kit. - uses seven absorbable forms of magnesium to support deeper sleep, calmer nerves, and real recovery. Get up to 35% off at with code BIONAT. - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to and use code NAT15 for 15% off your first order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39565250

#402: Gut Reset: The SECRET Signals for Longevity Revealed | How to Heal Your Microbiome, Banish Bloating, and Build Resilience With Nat Niddam 01/09/2026

#402: Gut Reset: The SECRET Signals for Longevity Revealed | How to Heal Your Microbiome, Banish Bloating, and Build Resilience With Nat Niddam Today, I’m kicking off the new year with a back-to-basics deep dive into one of the most pivotal yet overlooked foundations of longevity: gut health. Over the past episodes, we’ve explored everything from gene therapy to advanced tech, but it all comes back to the habits and systems we rely on every single day—and the gut is right at the center of that equation. Episode Timestamps: Gut health as the cornerstone of longevity ... 00:00:00 Why disease and wellness begin in the gut ... 00:03:46 Symptoms and signs of gut imbalance ... 00:08:53 Normalizing digestive discomfort ... 00:09:33 Key stressors for gut health: stress, poor food choices ... 00:12:03 How chronic stress disrupts digestion ... 00:12:59 Processed foods, toxins, and nutrient deficiencies ... 00:13:14 The importance of whole foods, healthy fats, and cooked veggies ... 00:14:27 Testing and understanding your own food tolerances ... 00:16:31 Risks of dehydration, overtraining, and PPIs ... 00:19:24 Structure of a healthy gut: digestion, gut barrier, organ support ... 00:23:19 Pre-meal rituals for better digestion ... 00:25:33 Choosing and introducing probiotics and fiber ... 00:37:44 Tracking your food and gut motility ... 00:42:12 Lifestyle habits: exercise, sleep, stress, meal timing ... 00:45:00 Avoiding snacking and late meals ... 00:49:05 Remove offenders, restore with enzymes, replenish with probiotics ... 00:50:12 Bone broth, anti-inflammatory foods, and gut repair ... 00:54:19 Peptides and bioregulators for organ optimization ... 00:57:03 Our Amazing Sponsors: - a multi-pathway sleep support from Wizard Sciences. It’s not a knockout pill; it’s a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit and use code NAT15 for 15% off. Sleep smarter, not harder. by LVLUP Health - supports your liver’s natural detox pathways so your body can reset after the holidays without suffering. Go to and use code NAT for 20% off. - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit and use code NAT20 for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39564085

#401: Personalization Is EVERYTHING: The New Science of Weight Health, GLP-1s, and Building Lasting Longevity With Ashley Koff 01/06/2026

#401: Personalization Is EVERYTHING: The New Science of Weight Health, GLP-1s, and Building Lasting Longevity With Ashley Koff Today, I’m joined by the insightful , renowned registered dietitian and fierce advocate for personalized, realistic nutrition that actually works in the real world. In this episode, Ashley Koff opens up about her personal and professional journey—from her early days in big brand marketing (think sugared cereals and infobesity) to her pivotal “aha” moments that led her to champion true weight health, not just weight loss. Episode Timestamps: Welcome and introduction to the Longevity Podcast ... 00:00:00 Personal experiences shaping nutrition philosophy ... 00:05:59 Influence of marketing on nutrition decisions ... 00:09:01 Big revelations: digestion, GLP-1, and health ... 00:16:43 The power of personalization in nutrition ... 00:19:59 The “Mr. Pizza Pop” case and behavioral change ... 00:23:03 Digestion as the foundation before diet quality ... 00:27:05 Dangers of generic “healthy diet” advice ... 00:36:01 GLP-1 medications: promise, risks, and prerequisites ... 00:40:10 Who truly needs GLP-1 versus lifestyle change alone ... 00:43:09 Muscle, bone, and shifting focus to building health ... 00:51:30 Nutrient intake, fiber, and supplement personalization ... 00:55:11 Digestive enzymes and optimizing digestion ... 01:03:10 Food noise, satiety, and psychological freedom ... 01:07:29 Ongoing assessment: tracking weight, fat, muscle ... 01:15:19 Weaning off GLP-1 and the importance of professional support ... 01:18:32 Our Amazing Sponsors: by Oxford Healthspan: Primeadine supports autophagy — your cells’ natural renewal and cleanup process — using food-derived spermidine, no fasting required. If you want to support resilience from the inside out, head to and use code BIONAT15 at checkout (one-time purchases only). by BiOptimizers: Better sleep isn’t about willpower — it’s about absorption. Magnesium Breakthrough uses seven real forms of magnesium that help you rest deeper and recover faster. Get up to 35% off at with code BIONAT. Bundle: pairs a probiotic proven to arrive 100% alive with digestive bitters that support digestion and curb cravings, so you actually feel the difference fast. Save 20% on your first Gut Essentials Bundle at with code NAT20 — 100% money-back guarantee. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39515105

#400: Why Chasing Muscle for Longevity Might Backfire: The Real Keys to Aging Well With Joel Greene. 01/02/2026

#400: Why Chasing Muscle for Longevity Might Backfire: The Real Keys to Aging Well With Joel Greene. Today, I’m excited to bring back the always thought-provoking , author of “The Immunity Code” and “The Way,” for a fresh conversation on why true longevity is about so much more than how much muscle you have or the latest diet trend you’re following. Joel Greene opens up about the hard lessons he’s learned from decades of self-experimentation and reveals why chasing that ideal gym physique might actually backfire as you age. Episode Timestamps: Welcome & episode introduction ... 00:00:00 The evolving nature of health and homeostasis ... 00:08:29 Beware rigid diet tribes—find nutritional flexibility ... 00:21:41 Biomarkers people miss: fasting insulin and acyl carnitines ... 00:23:11 Chronic ketosis, ATP, and metabolic slowdowns ... 00:25:16 Myth-busting muscle and the limits of bodybuilding for aging ... 00:27:17 Functional movement, flexibility, and big toe strength ... 00:34:29 Simple foundation: daily jumps or hops ... 00:47:41 Sensible protocols for muscle gain after 50 ... 01:00:07 Balance in diet as the true key to insulin sensitivity ... 01:08:06 Rules of thumb: meal timing for insulin ... 01:15:56 Stillness, faith, and feeding your spirit ... 01:21:56 Most abused supplement: Antioxidants ... 01:27:54 Body fat percentage as top longevity marker ... 01:29:12 Our Amazing Sponsors: - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it’s easy to try for yourself. Visit and use code NAT10 to start the free trial. from Young Goose - Brings the message back loud and clear. With NAD+ APEX™️ to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, “Hey, start making that collagen again!” It’s longevity science, not cosmetic hype. Visit —use code NAT10 to get started, or 5NAT if you’re an existing customer. are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. Get 35% off a one-month subscription at *Special deal through January 2026. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39495085

#399: Longevity Rewired: Hormones, Sunlight & The Weight Loss LIE | Reversing Aging in 2025 With Nat Niddam 12/26/2025

#399: Longevity Rewired: Hormones, Sunlight & The Weight Loss LIE | Reversing Aging in 2025 With Nat Niddam Today, I’m joined by a lineup of trailblazers in the science of longevity: , , , , , and . Together we dig into some of the most persistent myths and cutting-edge research shaping how we age—including why “eat less, move more” misses the mark, what really causes skin cancers, breast cancer screening risks, and the often-overlooked ripple effects of perimenopause. Links to full episodes: Episode Timestamps: Welcome & podcast overview ... 00:00:00 Longevity habits handout & sponsor plug ... 00:00:48 Clean protein choices & contamination risks ... 00:01:25 Calorie focus vs. hormones in weight loss ... 00:02:42 Why calories in/calories out fails ... 00:03:27 Cellular inflammation & gut microbiome in weight ... 00:04:43 Healthy, flexible metabolism over fast metabolism ... 00:07:51 Sun exposure, genetics & skin cancer ... 00:08:02 Sunscreen myths & ingredient safety ... 00:11:47 Perimenopause symptoms beyond hot flashes ... 00:12:27 Hormone replenishment: lifestyle + medical strategies ... 00:15:35 Breaking menopause myths & self-education ... 00:19:05 Blood factors & parabiosis in aging ... 00:21:37 Plasma exchange — practical and scientific updates ... 00:26:01 Western medicine vs. chronic disease reality ... 00:28:07 Breast cancer screening & over-treatment concerns ... 00:33:16 Hormone therapy after menopause—timing & benefits ... 00:37:07 Our Amazing Sponsors: protein powder is third-party tested for more than 200 contaminants, and Puori was the only brand that earned the Clean Label Project Transparency Certificate. That level of disclosure is rare. And refreshing. If you want protein that supports your goals — without the guesswork — go to and use code NAT for 32% off your first subscription or 20% off anything on the site. - Now in NEW Glass Jars - This isn’t regular honey. Manukora’s bees collect nectar from the Manuka tea tree, which packs 3x more antioxidants and prebiotics than normal honey. Plus it naturally contains MGO, that rare antibacterial compound. Head to to save up to 31% plus get $25 worth of free gifts with the Starter Kit. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39429540

#398: The Dopamine Biohack | Brain Chemistry, Motivation & Testosterone Secrets Revealed With Lucas Aoun 12/23/2025

#398: The Dopamine Biohack | Brain Chemistry, Motivation & Testosterone Secrets Revealed With Lucas Aoun Today, I’m joined by , from Australia, supplement formulator, and self-described human guinea pig. Lucas and I dive into his personal journey from working behind the counter at his father’s pharmacy, to experimenting with early nootropic formulas, and ultimately becoming a sought-after educator in the world of biohacking. Episode Timestamps: Podcast introduction and guest welcome ... 00:00:00 Lucas Aoun’s journey into biohacking ... 00:04:13 Innovative supplement formulation and teacrine ... 00:10:00 Dopamine’s role in motivation and productivity ... 00:32:09 Bioindividual supplement responses and AI in health ... 00:17:00 Alcohol alternatives and social nootropics ... 00:39:52 Optimizing exercise timing and performance ... 00:48:49 Testosterone, thyroid, and men’s health fundamentals ... 00:53:01 Diet diversity: carnivore, vegan, and healthy fats ... 00:59:19 Catwaba Pure: origins, benefits, and uses ... 01:13:12 Our Amazing Sponsors: - an advanced cognitive enhancement formula that combines fast-acting neuropeptides, cholinergic support, and mitochondrial-boosting compounds to sharpen mental clarity, memory, and long-term brain performance. Visit and use code NAT at checkout for 20% off. protein powder is third-party tested for more than 200 contaminants, and Puori was the only brand that earned the Clean Label Project Transparency Certificate. That level of disclosure is rare. And refreshing. If you want protein that supports your goals — without the guesswork — go to and use code NAT for 32% off your first subscription or 20% off anything on the site. : Urolithin A supports muscle strength and cellular energy. It’s about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you’d get from a glass of pomegranate juice. Visit and use code nat20 for 20% off your purchase. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39387320

#397: STRESS: The Silent Accelerator of Aging (10 Free Hacks Rewiring Your Longevity) | Calm Amid Chaos With Nat Niddam 12/19/2025

#397: STRESS: The Silent Accelerator of Aging (10 Free Hacks Rewiring Your Longevity) | Calm Amid Chaos With Nat Niddam Today, it’s just me, and we’re doing things a little differently on the Longevity Podcast. With the intensity of the holiday season winding down, I wanted to take a step back from the usual deep-dives and high-tech hacks to focus on something fundamental—free, practical strategies to help you manage stress. Chronic stress is sneaky in how it accelerates aging, impacts your telomeres, and undoes even the most powerful interventions, but thankfully, there are simple ways we can start to turn things around. Episode Timestamps: Welcome and episode introduction ... 00:00:00 Immune support with bioregulators ... 00:00:40 Why focus on free stress management tools ... 00:01:54 How chronic stress accelerates aging ... 00:04:32 Stress undermining longevity interventions ... 00:05:13 The importance of nervous system balance ... 00:06:50 Recognizing hidden stress and using HRV ... 00:07:45 When to seek further medical help ... 00:09:46 Recap: chronic stress shortens your healthspan ... 00:10:21 10 free strategies to manage stress ... 00:12:25 Connection and volunteering ... 00:13:15 Break the doom scrolling habit ... 00:17:37 Benefits of time in nature ... 00:20:02 Exercise for resilience ... 00:22:41 Breath work and vagus nerve support ... 00:25:33 Practicing gratitude daily ... 00:31:33 The power of sleep ... 00:34:30 Taking time for yourself ... 00:35:19 Our Amazing Sponsors: by Profound Helath - The Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. The Pineal Bioregulator supports your natural melatonin/circadian rhythm—key when schedules and daylight change—so you get the kind of sleep that underpins immune resilience. Head to and use code NAT15 for 15% off your first order. : C15 is 3x more effective than omega-3 and totally vegan. You can get an additional 15% off their 90-day subscription Starter Kit by going to and using code NATNIDDAM at checkout. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39387315

#396: From Trauma to Transcendence: Alpha Training, Elite Creativity Gains, and Reversing Aging — With Dr. James Hardt 12/16/2025

#396: From Trauma to Transcendence: Alpha Training, Elite Creativity Gains, and Reversing Aging — With Dr. James Hardt Today, I’m joined by —founder of Biocybernaut and a true pioneer in the world of neurofeedback. With over four decades spent mapping how our brainwaves shape emotions, performance, and even identity, Dr. Hardt has helped reframe the conversation around unlocking human potential, making cutting-edge brain training accessible to seekers, creatives, and everyday biohackers alike. Download a FREE copy of his book “The Art of Smart Thinking” at Episode Timestamps: Intro to Longevity Podcast and host ... 00:00:00 Introduction to Dr. James Hardt and neurofeedback ... 00:00:34 Alpha brain waves: effects on trauma, creativity, IQ, EQ, and longevity ... 00:00:57 Biocybernaut and personal experience ... 00:00:49 Overview of neurofeedback basics and early challenges ...00:12:14 Brainwave types explained (delta, theta, alpha, etc.) ... 00:22:12 Importance of alpha training ... 00:29:37 Neurofeedback benefits: creativity, IQ, EQ, and emotional trauma ... 00:39:34 Alpha waves, aging, and longevity ... 00:46:58 Accessible strategies to boost alpha ... 00:51:55 Subconscious mind, ego, and forgiveness work ... 00:58:02 Case studies and health breakthroughs ... 01:01:27 Future of neurofeedback: AI and accessibility ... 01:05:53 Personal transformation and closing remarks ... 01:14:22 Our Amazing Sponsors: - Cold season doesn’t have to take you out. I use Tro Mune—a nightly buccal troche with 75 mg cordycepin—to build immune resilience while I sleep. Take ½–1 before bed, and use it before you get sick or right when you feel it. m, use NAT10, and get 10% off your first order. - a multi-pathway sleep support from Wizard Sciences. It’s not a knockout pill; it’s a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit and use code NAT15 for 15% off. Sleep smarter, not harder. brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, “Hey, start making that collagen again!” It’s longevity science, not cosmetic hype. Visit —use code NAT10 to get started, or 5NAT if you’re an existing customer. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39387310

#395: Brain Fog, Anger, Detox Secrets & The Truth About Diet Sodas | Unlocking LIVER Longevity With Siggi Clavien 12/12/2025

#395: Brain Fog, Anger, Detox Secrets & The Truth About Diet Sodas | Unlocking LIVER Longevity With Siggi Clavien Today, I’m sitting down with the irrepressible , renowned biotech innovator and founder of , a groundbreaking formula for liver health. Siggi’s story is deeply personal—motivated by the loss of loved ones to liver disease, he’s made it his life’s mission to demystify liver health and help others avoid the fate that touched his own family. Visit code: NAT for 5% off Episode Timestamps: Introduction and podcast themes ... 00:00:00 Eastern vs. Western liver views ... 00:07:09 Why liver health is central to longevity ... 00:09:28 Hidden toxins: everyday exposures ... 00:12:10 Emotional toxicity and liver ... 00:16:06 Imaging vs. blood tests for liver health ... 00:17:22 Fatty liver trends, risk factors, and children ... 00:20:24 Cirrhosis: new causes, gallbladder link ... 00:25:21 Diet, drugs, and detox ... 00:30:07 Supporting detox daily ... 00:33:39 Fatty liver, metabolism, and key nutrients ... 00:36:41 Liver’s impact on mood, brain, hormones ... 00:44:22 Menopause, hormones, and the liver ... 00:47:43 Supplements, packaging, and hidden chemicals ... 00:56:07 Fasting, microplastics, and weight loss stress ... 00:59:29 Deliverance formula: development and benefits ... 01:08:06 Guidance for using Deliverance ... 01:24:04 Core habits: hydration, alcohol, diet soda ... 01:25:39 Our Amazing Sponsors: from Young Goose: brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, “Hey, start making that collagen again!” It’s longevity science, not cosmetic hype. Visit —use code NAT10 to get started, or 5NAT if you’re an existing customer. : C15 is 3x more effective than omega-3 and totally vegan. You can get an additional 15% off their 90-day subscription Starter Kit by going to and using code NATNIDDAM at checkout. : The Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. The Pineal Bioregulator supports your natural melatonin/circadian rhythm—key when schedules and daylight change—so you get the kind of sleep that underpins immune resilience. Head to and use code NAT15 for 15% off your first order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39266720

#394 How Bioregulator Peptides HALVE Mortality: Telomere Reversal, Organs REGENERATED & the 8-Year Experiment With Dr. Bill Lawrence 12/09/2025

#394 How Bioregulator Peptides HALVE Mortality: Telomere Reversal, Organs REGENERATED & the 8-Year Experiment With Dr. Bill Lawrence Today, I’m joined once again by the incredible Dr. Bill Lawrence, a true pioneer in the field of longevity research and one of the most requested guests on this podcast. Dr. Lawrence trained directly with Professor Vladimir Khavinson—the scientist who discovered and developed bioregulator peptides—and has spent the last eight years leading some of the most exciting field research in this space. Episode Timestamps: Welcome and introduction to Longevity Podcast ... 00:00:00 Origins and early use of bioregulator peptides in Soviet research ... 00:05:39 Organ-specific peptide mechanisms and targeting ... 00:08:28 Dr. Lawrence’s collaboration with Professor Cavinson ... 00:12:17 Overview of American clinical studies and study protocols ... 00:14:13 Measuring biological age: telomeres and epigenetic markers ... 00:15:06 Key Russian studies and impact of peptides on mortality ... 00:17:00 Peptides as ultimate epigenetic switches and DNA repair ... 00:20:00 Importance of pineal and thymus peptides in protocols ... 00:22:28 Advances in peptide testing and lab beta-testing ... 00:28:05 Clinical outcomes: organ regeneration and normalized function ...00:35:54 Bioregulator peptides vs. synthetics: modulation vs. boosting ... 00:39:28 Dr. Lawrence’s personal telomere and epigenetic age results ... 01:07:56 Impact of stress and meditation on telomere length ... 01:10:37 Group results: significant telomere and epigenetic age reversal ... 01:13:03 System-level organ age tracking and protocol targeting ... 01:27:14 International expansion and next steps in peptide research ... 01:37:03 Our Amazing Sponsors: - near-infrared light helps improve circulation, oxygen delivery, and mitochondrial function, which can support focus, recovery, and even overall brain health. Visit and get 10% off! - Mineral deficiency support. One shot in the morning, tastes like water, and you’ve just restored every essential mineral your cells are craving. Go to , use code NAT20, and get 20% off your first order. - an advanced cognitive enhancement formula that combines fast-acting neuropeptides, cholinergic support, and mitochondrial-boosting compounds to sharpen mental clarity, memory, and long-term brain performance. Visit and use code NAT at checkout for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39249995

#393: Laugh, Sweat, Detox: The Misunderstood Pathways to PEAK Health (Mitochondria, Doomscrolling, and Sex) With Dr. Ted Achacoso 12/05/2025

#393: Laugh, Sweat, Detox: The Misunderstood Pathways to PEAK Health (Mitochondria, Doomscrolling, and Sex) With Dr. Ted Achacoso Today, I'm joined by the incomparable —a true pioneer in shifting healthcare from “what’s wrong with you” to “what’s right with you.” Trained across neurology, pharmacology, AI, and nutritional medicine, Dr. Achacoso brings a sharp mix of science, humor, and unfiltered honesty to our conversation. We get real about what it takes to optimize health at the cellular level, why metabolomics is the future doctors can’t ignore, and how something as simple as a toxicity panel can completely change your health trajectory. Episode Timestamps: Welcome and episode introduction ... 00:00:00 Science, laughter, and Dr. Ted’s background ... 00:00:38 Early curiosity, accelerated medical pathway ... 00:07:20 Reframing healthcare: from disease to wellness ... 00:14:04 Cell danger response and importance of metabolomics ...00:16:15 Case study: toxicity panel as diagnostic game-changer ... 00:35:17 Patient motivation and behavioral change ... 00:44:20 Vitamin D: its underestimated power and role ... 00:51:12 Vitamin D paradox, genetics, and medication effects ... 01:00:34 Daily longevity habits and mindset ... 01:22:03 Longevity in one word: balance ... 01:33:05 Home Hope resources and closing ... 01:35:20 Our Amazing Sponsors: - Cold season doesn’t have to take you out. I use Tro Mune—a nightly buccal troche with 75 mg cordycepin—to build immune resilience while I sleep. Take ½–1 before bed, and use it before you get sick or right when you feel it. m, use NAT10, and get 10% off your first order. - One capsule before eating helps your body absorb more nutrients, ease digestion, and leave you feeling light instead of weighed down. Head over to and use code NAT20 for 20% off. - a multi-pathway sleep support from Wizard Sciences. It’s not a knockout pill; it’s a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit and use code NAT15 for 15% off. Sleep smarter, not harder. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39179670

#392: Biohacking the MIND: 78% Anxiety Remission, Vagus Nerve Secrets & The Mental Health Revolution | Zenbud’s Jon Hacker Unlocks REST 11/26/2025

#392: Biohacking the MIND: 78% Anxiety Remission, Vagus Nerve Secrets & The Mental Health Revolution | Zenbud’s Jon Hacker Unlocks REST Today, I’m joined by the innovative , whose name couldn’t be more perfect for the biohacking space. While his family hacks computers, Jon decided to hack something a bit messier—the human mind. After growing up with severe OCD and witnessing the rising tide of global anxiety, he became obsessed with one question: Why are we all stuck in fight or flight, and what can we actually do about it? Use code NAT at for 15% off Episode Timestamps: Introduction to Longevity Podcast and Host ... 00:00:00 The Rise of Anxiety and Mental Health Innovation ... 00:05:19 Why Modern Society Fuels Anxiety ... 00:07:18 Impact of Chronic Stress on Health ... 00:08:51 Barriers to Managing Anxiety with Habits Alone ... 00:17:17 CBT and the Need for Better Tools ... 00:19:27 Vagus Nerve: What It Does and Why It Matters ... 00:20:37 Zenbud: Ultrasound vs. Electrical Stimulation ... 00:28:58 Zenbud Headset Experience and Simplicity ... 00:34:25 Zenbud’s Role in Stress Resilience and Longevity ... 00:47:45 Purpose, Mindfulness, and the Future of Biohacking ... 00:50:55 Zenbud: Key Safety Points and Adoption Challenges ... 01:01:08 Zenbud as “An Off Switch for Stress” and Closing ... 01:02:52 Final Tips, Special Offer, and Outro ... 01:03:30 Our Amazing Sponsors: - When your skin makes vitamin D from UVB light, it also creates natural companion molecules that help your body use it smarter—so you’re not just boosting levels, you’re activating your biology the way nature intended. Visit . You’ll receive 10% off! NAT10 will be automatically applied at checkout. : Urolithin A supports muscle strength and cellular energy. It’s about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you’d get from a glass of pomegranate juice. Visit and use code nat20 for 20% off your purchase. - uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at and use code BIONAT for 15% off any order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39178475

#391: Unlocking SCALP Health: The Biohack That Will Change Your Hair Forever With Nadine Artemis 11/28/2025

#391: Unlocking SCALP Health: The Biohack That Will Change Your Hair Forever With Nadine Artemis Today, I’m joined by the incredible , a true pioneer in natural beauty and holistic health. Nadine is well known for bridging the gap between ancient wisdom and modern science, and in this episode, she completely redefines how we look at hair care—not just as a cosmetic routine, but as a form of biological reset. She shares how everything from stress to toxins and even your shower water can disrupt the delicate ecosystem of your scalp, and how her simple, nature-inspired rituals can help restore balance. Past episode: Study with Rosemary: Episode Timestamps: Episode introduction and focus on hair health ... 00:00:00 Meet Nadine Artemis and “Renegade Beauty” ... 00:04:05 Hair and oral health as longevity signals ... 00:09:33 Skin/scalp microbiome and product residues ... 00:12:01\ Stress, hormones, and pandemic hair loss ... 00:14:14 Optimizing hair follicle growth and supplements ... 00:15:43 Scalp cleansing, massaging, and circulation ... 00:21:25 Filtering water and natural scalp treatments ... 00:26:08 Rosemary oil, melatonin for hair regrowth ... 00:32:15 Photobiomodulation and red light for scalp ... 00:36:30 Essential oils—antimicrobial, support for dandruff ... 00:51:09 Practical routines for dry/flaky vs. oily scalp ... 01:05:49 Navigating hormonal and age-related hair changes ... 01:07:07 Summary of effective natural hair care strategies ... 01:16:00 Our Amazing Sponsors: : near-infrared light helps improve circulation, oxygen delivery, and mitochondrial function, which can support focus, recovery, and even overall brain health. Visit and get 10% off! : C15 is 3x more effective than omega-3 and totally vegan. You can get an additional 15% off their 90-day subscription Starter Kit by going to and using code NATNIDDAM at checkout. - From remote forests in New Zealand, where bees collect nectar from the native Manuka tea tree. That nectar is naturally rich in antibacterial compounds like MGO, plus antioxidants and prebiotics that support immunity and gut health. Visit to save up to 31% plus $25 worth of free gifts with the Starter Kit - you’ll get an MGO 850+ Manuka Honey jar, 5 travel sticks, a wooden spoon, and a guidebook. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39096300

#390: Muscle, Mitophagy, and Longevity: How Urolithin A Supports Healthy Aging and Athletic Performance With Brad Currier, PhD 11/25/2025

#390: Muscle, Mitophagy, and Longevity: How Urolithin A Supports Healthy Aging and Athletic Performance With Brad Currier, PhD Today, I’m joined by Dr. Brad Currier, Manager of Clinical Trials at and an expert in the world of muscle and aging research. Brad is on the cutting edge of mitochondrial science, and in this episode, he helps us unravel the mysteries of why some 80-year-olds are still crushing it in the gym while others struggle to get up the stairs. We dive into his fascinating research on mitophagy—our bodies’ system for recycling dysfunctional mitochondria—and what it means for muscle health, strength, and vibrant aging. Visit and use code nat20 for 20% off your purchase. Episode Timestamps: Episode start … 00:00:00 What is Mitophagy? Why It Matters as We Age ... 00:04:53 Mitophagy in Athletes vs. General Population ... 00:07:15 Urolithin A and Why Most People Can’t Make It ... 00:12:12 What Mitopure Does: Mitophagy and Biogenesis ... 00:24:10 Key Study: Strength Gains in Middle-Aged Adults ... 00:26:43 Dose Guidance: 500mg vs. 1g ... 00:31:39 Anti-Inflammatory Effects and Immune Health ... 00:33:07 Benefits Beyond Muscle: Skin, Immunity, Brain ... 00:35:01 Weightlifter Study: Performance in Trained Athletes ... 00:40:34 Mitopure for Recovery and User Experiences ... 00:46:41 How to Use Mitopure: Timing, Dosage, Consistency ... 00:52:54 Protein, Creatine, and Mitopure: The Basics Stack ... 00:53:41 Recovery, Cycling, and How Soon Benefits Appear ... 00:58:44 Debunking Myths: Pomegranate, Antioxidant, Athletes Only ... 01:10:26 Mitopure vs. Generic Urolithin A: Safety Concerns ... 01:13:39 Our Amazing Sponsors: - a multi-pathway sleep support from Wizard Sciences. It’s not a knockout pill; it’s a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit and use code NAT15 for 15% off. Sleep smarter, not harder. - Cold season doesn’t have to take you out. I use Tro Mune—a nightly buccal troche with 75 mg cordycepin—to build immune resilience while I sleep. Take ½–1 before bed, and use it before you get sick or right when you feel it. m, use NAT10, and get 10% off your first order. - The Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. The Pineal Bioregulator supports your natural melatonin/circadian rhythm—key when schedules and daylight change—so you get the kind of sleep that underpins immune resilience. Head to and use code LONGEVITY15 for 15% off your first order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39035880

#389: How Migraines, Mitochondria Dysfunction, and Modern Lifestyles Impact Brain Health and Aging With Elena Gross 11/21/2025

#389: How Migraines, Mitochondria Dysfunction, and Modern Lifestyles Impact Brain Health and Aging With Elena Gross Today, I’m joined by the brilliant , a neuroscientist with an inspiring story and a relentless drive to solve the mysteries behind chronic migraines and brain health. Dr. Gross’s personal journey—enduring twenty days of migraine each month and navigating countless failed treatments—led her from crawling through the pain to founding Brain Ritual, a company reimagining brain fuel for longevity. Episode Timestamps: Intro and offers ... 00:00:00 Elena Gross’s journey from chronic migraines to neuroscience ... 00:46 Distinguishing migraines from headaches ... 08:13 Energy deficit in the brain and ketones as a solution ... 15:05 Mechanisms and benefits of ketones for brain health ... 23:03 Micronutrients and mitochondrial support ... 28:20 Perfume, toxins, and migraine triggers ... 32:30 Hormonal, dietary, and oxidative stress factors in migraines ... 34:33 Exogenous ketones: Types, safety, and application ... 44:43 Brain Ritual supplement overview ... 47:04 Expanding beyond migraines: Mitochondria and neuropsychiatric health ... 57:31 Four pillars for mastering migraines ... 67:00 Actionable starting step for listeners ... 71:58 How to access Brain Ritual and community ... 73:10 Our Amazing Sponsors: - Most cheap Ashwagandha is bulked up with stems and leaves to inflate the “actives.” Those parts can bring compounds you don’t actually want in your body. A root-only extract containing four newly identified bioactives, the ASHX4 Complex. Visit and use code NAT25 for 25% off. - A plant-based supplement protocol designed to enhance stem cell function. support your recovery, flexibility, and long-term vitality. Visit and use code: NAT15 for 15% off your order. - brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, “Hey, start making that collagen again!” It’s longevity science, not cosmetic hype. Visit —use code NAT10 to get started, or 5NAT if you’re an existing customer. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/38994765

#388: Nat’s Ultimate Gift Guide for Longevity Fans: Biohacks, Wellness Gadgets, and Black Friday Deals 11/18/2025

#388: Nat’s Ultimate Gift Guide for Longevity Fans: Biohacks, Wellness Gadgets, and Black Friday Deals Today, I’m sharing my go-to biohacking strategies and supplement stacks for leveling up your health and longevity. After years of testing the latest tech and science-backed interventions, I’ve curated smart bundles for better sleep, sharper focus, and lasting energy—perfect for your own routine or thoughtful holiday gifting. We’ll cover why each pick works, from essentials like magnesium and Urolithin A to recovery devices and productivity tools. You'll also get the inside scoop on practical ways to personalize your approach and make smart choices during seasonal sales. If you’re looking to supercharge your well-being or help someone you love feel their best, this episode is your actionable guide to vitality, clarity, and thriving all season long. Go To for all the holiday deals! Episode Timestamps: Intro and offers ... 00:00:00 Sleep and recovery bundles: Trocalm, Troz, magnesium, gadgets ... 05:43 Serenity and Sanity Set for busy moms ... 10:37 Fitness and workout performance bundles ... 13:23 Foodie and longevity nutrition gifts ... 19:13 Nitric oxide and vegetable support ... 21:57 Anti-aging skin and vitality bundles ... 23:06 Golden Glow bundle: Stem Regen, Prodrome, bioregulators ... 25:20 Wellness and immune support bundles ... 29:05 Biohacker and luxury splurge bundles ... 31:16 Focus and home office essentials ... 33:58 Hydrogen, water, and holistic elements ... 40:01 Our Amazing Sponsors: - an advanced cognitive enhancement formula that combines fast-acting neuropeptides, cholinergic support, and mitochondrial-boosting compounds to sharpen mental clarity, memory, and long-term brain performance. Visit and use code NAT at checkout for 20% off. : Urolithin A supports muscle strength and cellular energy. It’s about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you’d get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase. - Two Berkeley Life capsules deliver the dietary nitrates your body needs to support nitric oxide production. When you subscribe at , you’ll get a free tube of 50 Nitric Oxide test strips with your first delivery. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/38999385

#387: How To Start Tracking Your Own Biomarkers & Which Ones To Track | Become the CEO of Your Health With Dr. Darshan Shah 11/14/2025

#387: How To Start Tracking Your Own Biomarkers & Which Ones To Track | Become the CEO of Your Health With Dr. Darshan Shah Today, I’m joined by the inspiring , a board-certified surgeon who made the bold leap from the operating room to the forefront of longevity and functional medicine. In our conversation, opens up about his own journey through burnout, chronic illness, and autoimmune disease, and shares how simple, consistent lifestyle changes became the real medicine that transformed his health. His experience revealed firsthand just how powerful habits like movement, proper nutrition, and sleep can be—often succeeding where surgery and prescriptions fell short. Episode Timestamps: Intro and offers ... 00:00:00 Dr. Darshan Shah’s journey from surgery to lifestyle medicine ... 00:04:37 Simple actions: nutrition, movement, habit formation ... 00:08:41 Challenges of doctors embracing lifestyle changes ... 00:11:06 Building a parallel system: prevention and chronic care ... 00:14:32 Empowering patients: tech, wearables, and AI ... 00:18:27 Therapeutic plasma exchange (TPE): mechanism and safety ... 00:27:47 Essential biomarker and at-home tests ... 00:48:19 Continuous glucose monitors and real-time health feedback ... 00:52:33 Next Health model: prevention, functional, lifestyle, longevity ... 00:43:08 Longevity circuit: cellular gym approach ... 00:59:37 Liquid biopsy and early cancer detection ... 01:02:08 Advice for health, self-care, and lifelong vitality ... 01:09:31 Where to learn more and clinic expansion ... 01:10:26 Our Amazing Sponsors: - From remote forests in New Zealand, where bees collect nectar from the native Manuka tea tree. That nectar is naturally rich in antibacterial compounds like MGO, plus antioxidants and prebiotics that support immunity and gut health. Visit to save up to 31% plus $25 worth of free gifts with the Starter Kit - you’ll get an MGO 850+ Manuka Honey jar, 5 travel sticks, a wooden spoon, and a guidebook. *Look out for their Black Friday/Cyber Monday promotion from 11/17/25 - 12/02/25.. + - A groundbreaking, doctor-formulated vegan formula that boosts your NAD levels by up to 67% for enhanced cellular energy, DNA repair, and detox support. Go to and use promo code NATHALIE to get 15% off—and try it risk-free with their 100-day money-back guarantee. - uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at and use code BIONAT for 15% off any order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/38935985

#386: How To Boost VO2 Max And HRV: The Missing Tool For Your Performance and Recovery With Rowena Gates 11/11/2025

#386: How To Boost VO2 Max And HRV: The Missing Tool For Your Performance and Recovery With Rowena Gates Today, I’m joined by the inspiring Rowena Gates, co-founder of ENG3 and the innovative mind behind the device—a technology specialized in supporting cellular repair and resilience. Rowena Gates shares her unique journey from teaching high school and academic consulting to pioneering advanced biotech for health optimization. Her story is a powerful reminder of how unlikely paths can lead to groundbreaking innovation in longevity science. Visit and receive a free pelican carrying case with your order of Episode Timestamps: Intro and offers ... 00:00:00 Role of reactive oxygen species and NanoVi’s mechanism ... 00:07:11 Protein folding, DNA repair, and longevity ... 00:11:00 NanoVi’s impact on NAD IV tolerance and stress ... 00:16:07 Ordered water and protein folding explained ... 00:22:10 VO2 max, metabolic efficiency, and biological age ... 00:27:39 Guidelines for NanoVi: Performance, recovery, and hormesis ... 00:34:44 Brain endurance and cognitive recovery ... 00:39:09 Sleep, HRV, and effects on older adults ... 00:43:46 Anecdotes: ED, cardiovascular health, notable users ... 00:46:33 NanoVi at home: Sleep, recovery, workday use ... 00:51:02 Stacking with other modalities (hyperbaric, red light) ... 01:00:05 Vision: Accessibility via shared devices ... 01:02:07 Main message: Body’s capacity to repair ... 01:04:40 Our Amazing Sponsors: - With NAD+ APEX™️ to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, “Hey, start making that collagen again!” It’s longevity science, not cosmetic hype. Visit —use code NAT10 to get started, or 5NAT if you’re an existing customer. - Mineral deficiency support. One shot in the morning, tastes like water, and you’ve just restored every essential mineral your cells are craving. Go to , use code NAT20, and get 20% off your first order. - a multi-pathway sleep support from Wizard Sciences. It’s not a knockout pill; it’s a gentle nudge toward that wind-down zone. Take 30 minutes before bed, and it helps your body and brain sync up for sleep. Visit and use code NAT15 for 15% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/38909190

#385: How To Outsmart Cold & Flu Season — NAT’S Survival GUIDE For You & The Family (Supplements, Sleep, What to Avoid) 11/07/2025

#385: How To Outsmart Cold & Flu Season — NAT’S Survival GUIDE For You & The Family (Supplements, Sleep, What to Avoid) Today, let’s talk about immune support. With the festive season and colder months upon us, it’s the perfect time to focus on practical strategies to help you build a resilient, balanced immune system. I share not only the science-backed basics—like sleep, stress management, and the realities of sugar and alcohol—but also my favorite low-tech tools and innovative supplements for fortifying your body’s natural defenses. Studies Mentioned: Supplements Mentioned: : Manuka Honey (save up to 31%) : Terrific Vitamin C Effervescent Tablets includes Zinc, D3, Yerba Matte, Ginseng - use in the am (use code NAT for 20% off) - TroMMune, TroCalm, TroZZ (use NAT10, and get 10% off your first order) : Spore Biotics (use code NAT20 for 20% off) :Ultimate GI Repair (use code NAT at checkout for 20% off) : ImmunoRESTORE+ (use code LONGEVITY) : Pineal Gland and Thymus (use code LONGEVITY15 for 15% off ) Episode Timestamps: Intro and offers ... 00:00:00 Balancing the immune system vs. boosting ... 00:01:32 Risks of an overactive immune response ... 00:02:55 Lifestyle practices for immune health ... 00:03:38 Sleep’s role and practical sleep tips ... 00:04:41 Sugar’s impact on immunity ... 00:09:05 Alcohol, mocktails, and immune suppression ... 00:15:26 Managing stress for immune support ... 00:18:19 Summary of key lifestyle strategies ... 00:24:36 Exercise: benefits and moderation ... 00:26:26 Top supplements for immune support ... 00:28:59 Propolis, Manuka honey, vitamins and probiotics ... 00:29:34 Bioregulators and peptide support ... 00:38:42 Sauna and light therapy for winter immunity ... 00:40:01 Take action before the holiday season ... 00:42:28 Our Amazing Sponsors: : an advanced cognitive enhancement formula that combines fast-acting neuropeptides, cholinergic support, and mitochondrial-boosting compounds to sharpen mental clarity, memory, and long-term brain performance. Visit and use code NAT at checkout for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/38729415

#384: Trading Ego For EMBODIMENT: Unlocking Deep Healing with Psilocybin & Ayahuasca | From Startup Hustle to Spiritual Awakening (with Austin Mao) 11/04/2025

#384: Trading Ego For EMBODIMENT: Unlocking Deep Healing with Psilocybin & Ayahuasca | From Startup Hustle to Spiritual Awakening (with Austin Mao) Today, I’m joined by Austin Mao, a serial entrepreneur whose personal journey with plant medicine led him from the high-pressure, Instagram-perfect startup world to founding —one of the leading psychedelic organizations in the U.S. In this candid conversation, Austin shares how a transformative psilocybin ceremony unraveled the layers of ego, revealing new depths of presence, embodiment, and emotional healing. Episode Timestamps: Austin’s first plant medicine ceremony: ego, healing, and memories ... 00:06:28 Uncovering childhood trauma and learning presence ... 00:08:34 Motivations for plant medicine: curiosity, networking, and pride ... 00:13:46 Core lessons: ego, external vs. internal fulfillment ... 00:14:57 Comparing ayahuasca and psilocybin: safety, access, and tradition ... 00:18:27 Facilitator training and role in psychedelic experiences ... 00:24:48 Purging, meaning-making, and emotional release in ceremony ... 00:27:39 Psychedelics and mental health: impact and effectiveness ... 00:31:27 Retreat model: psilocybin first, ayahuasca later ... 00:37:20 The crucial role of integration post-ceremony ... 00:41:00 Ceremonia’s offerings: retreats, online integration, and microdosing ... 00:47:59 Our Amazing Sponsors: - The Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. The Pineal Bioregulator supports your natural melatonin/circadian rhythm—key when schedules and daylight change—so you get the kind of sleep that underpins immune resilience. Head to and use code LONGEVITY15 for 15% off your first order. - When your skin makes vitamin D from UVB light, it also creates natural companion molecules that help your body use it smarter—so you’re not just boosting levels, you’re activating your biology the way nature intended. Visit . You’ll receive 10% off! NAT10 will be automatically applied at checkout. : Urolithin A supports muscle strength and cellular energy. It’s about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you’d get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/38729410

#383: Freeze Time—Literally: Bank Your Hair Follicles For Future Skin Renewal, Hair Regrowth, and Even Wound Healing With Drew Taylor 10/31/2025

#383: Freeze Time—Literally: Bank Your Hair Follicles For Future Skin Renewal, Hair Regrowth, and Even Wound Healing With Drew Taylor Today, I’m joined by , a trailblazer in regenerative medicine and the innovative force behind . Dr. Taylor’s path is anything but ordinary—he went from pitching in professional baseball to pioneering non-invasive ways to collect and preserve the body’s most potent cells, all sourced from our hair follicles. His journey is a testament to the power of curiosity, resilience, and the drive to use cutting-edge science for better health and longevity. ONE-FREE Year of Hair Follicle Banking: Whether it’s for present use or future use, you get one full year of free banking. All you have to do is find a clinic that offers Acorn near you, sign up for your hair follicle harvest, and then go to and use code NAT at checkout to get one free year of banking. Episode Timestamps: Dr. Drew Taylor’s journey: pro athlete to stem cell science ... 00:06:24 Transition from sports to regenerative medicine ... 00:09:45 Advances in stem cell therapy and cell reprogramming ... 00:11:01 Donor vs. autologous stem cell differences ... 00:12:12 Stem cell hierarchy and pluripotency explained ... 00:19:00 Limits of biological age tests ... 00:23:27 Non-invasive harvesting from hair follicles ... 00:27:36 Advantages of hair follicle cells ... 00:30:10 Age and timing for cell banking ... 00:33:02 Wound healing case study with secretome ... 00:38:19 Secretome, exosomes, and topical treatment potential ... 00:40:43 Hair regrowth and transplant support ... 00:52:12 Accessibility and affordability of Acorn’s approach ... 00:56:40 Cryopreservation as a “biological insurance policy” ... 00:59:42 Microneedling and aesthetic results ... 01:00:39 Future uses: sports injuries, immune cells, organ regeneration ... 01:04:30 Final advice for longevity and health span ... 01:13:16 How to access Acorn’s services ... 01:15:18 Our Amazing Sponsors: - Minimally processed, made from pasture-raised cows’ milk, and it’s tested for over 200 contaminants every single batch. Go to and use code NAT for 20% off— it also applies to subscriptions so you’ll get nearly a third off the price. - Near-infrared light helps improve circulation, oxygen delivery, and mitochondrial function, which can support focus, recovery, and even overall brain health. Visit and get 10% off! - One capsule before eating helps your body absorb more nutrients, ease digestion, and leave you feeling light instead of weighed down. Head over to and use code NAT20 for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/38739735

#382: Building Stronger Women from their 20s to their 70s: Hormones, Iron Testing, and Menopause Breakthroughs With Dr. Amy Killen 10/28/2025

#382: Building Stronger Women from their 20s to their 70s: Hormones, Iron Testing, and Menopause Breakthroughs With Dr. Amy Killen Today, I’m thrilled to welcome , a visionary in hormone optimization and regenerative medicine who is transforming the conversation around women’s health and longevity. In this episode, shares her personal journey—from witnessing her mother’s struggle after a hip fracture, to becoming a steadfast advocate for correcting the myths and misinformation that still surround estrogen, progesterone, and testosterone optimization. Episode Timestamps: Ferritin, iron, and hormonal health basics ... 00:00:43 Dr. Amy Killen’s evolving hormone focus ... 00:04:02 Women’s Health Initiative and estrogen myths ... 00:06:31 Importance of hormone optimization vs. stem cells ... 00:10:25 Testosterone for women: symptoms, labs, delivery options ... 00:12:05 Side effects and nuances of testosterone therapy ... 00:14:01 SHBG, free testosterone, and lab variability ... 00:16:38 Libido, PT-141, and the biopsychosocial lens ... 00:21:46 Iron and ferritin: sweet spot and skin implications ... 00:29:16 Hot vs. HRT: definitions and individualization ... 00:34:23 Debunking estrogen and breast cancer myths ... 00:41:30 Aging expectations and finding the right doctor ... 00:43:18 Advice for women by decade—20s, 30s, 40s, etc. ... 00:47:20 Our Amazing Sponsors: - This isn’t just melatonin—it’s a powerhouse! Oblipair gives you honokiol and agarin to enhance GABA binding, while adenosine and cordycepin boost sleep drive and deep sleep. CBD, CBN, and 5‑HTP round it out. Head to , use NAT10, and get 10% off your first order. - A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. : uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at and use code BIONAT for 15% off any order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/38603165

#381: Better Than Lasers: NAD+, Spermidine, and Methylene Blue for Youthful Skin | Amitay Eshel and Anastasia Khodzhaeva 10/24/2025

#381: Better Than Lasers: NAD+, Spermidine, and Methylene Blue for Youthful Skin | Amitay Eshel and Anastasia Khodzhaeva Today, I’m joined by the pioneering duo behind and two of the earliest voices to bring longevity science into the world of skincare. Amitay comes from the red light therapy space, while Anastasia’s background is rooted in cancer research and regenerative medicine—together, their bold thesis is that youthful skin is not just about appearance, it’s an energy state. Visit —use code NAT10 to get started, or 5NAT if you’re an existing customer. Episode Timestamps: Skin longevity: appearance vs resilience vs long-term health ... 00:06:42 Why topical NAD matters for skin ... 00:14:07 Importance and decline of NAD as we age ... 00:18:26 Why spermidine was added to skincare ... 00:21:00 How spermidine drives autophagy and hydration ... 00:25:43 Spermidine’s impact on wrinkles and skin barrier ... 00:29:06 Longevity skincare vs traditional approaches ... 00:31:18 Methylene blue’s unique benefits and formulation ... 00:34:04 Methylene blue vs other antioxidants ... 00:36:16 Methylene blue’s role in recovery and protection ... 00:46:13 Platelet-derived, quantified exosomes explained ... 00:51:44 How to layer exosomes in your skincare ... 01:01:13 Biggest myths in skin longevity ... 01:02:41 Does topical NAD and spermidine really work? ... 01:08:28 Where to start with Young Goose products ... 01:19:33 Our Amazing Sponsors: - One capsule before eating helps your body absorb more nutrients, ease digestion, and leave you feeling light instead of weighed down. Head over to and use code NAT20 for 20% off. : It’s minimally processed, made from pasture-raised cows’ milk, and it’s tested for over 200 contaminants every single batch. It’s also very Yummy! Go to and use code NAT for 20% off— it also applies to subscriptions so you’ll get nearly a third off the price. - Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. Pineal Bioregulator supports your natural melatonin/circadian rhythm so you get the kind of sleep that underpins immune resilience. Head to and use code LONGEVITY15 for 15% off your first order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/38594855

LONGEVITY with Nathalie Niddam

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