LONGEVITY with Nathalie Niddam

LONGEVITY with Nathalie Niddam is your go-to podcast for diving deep into the science and practices for increasing your longevity and healthspan. This podcast covers topics from nutrition, biohacking, longevity, peptides, bioregulators, cutting edge research, health technology and more! Nathalie Niddam is a certified nutritionist, as well as a epigenetics and human potential coach.

#426: The Invisible Price of Poor Sleep and How To Fix It, Tech Hacks That Save Marriages, and the Longevity Equation — With Melissa Urban 04/03/2026

#426: The Invisible Price of Poor Sleep and How To Fix It, Tech Hacks That Save Marriages, and the Longevity Equation — With Melissa Urban Today, I’m joined by the amazing , the force behind Whole30 and a global champion of accessible nutrition. In our conversation, Melissa opens up about a surprising discovery in her wellness journey: sleep, not just food, is often the real foundation of long-term health. She shares how overlooked sleep hijacked her cravings, impacted her insulin sensitivity, and even chipped away at her resilience—revealing the invisible costs that only show up years down the line. Visit and use code NAT to get $75 off Episode Timestamps: Welcome and podcast introduction ... 00:00:00 Poor sleep’s impact on cravings and insulin ... 00:00:47 Melissa Urban’s wake-up calls: burnout and disrupted sleep ... 00:00:59 Tech sleep hack: Ozlo noise-canceling earbuds ... 00:01:06 Sleep’s effect on diet and insulin sensitivity ... 00:06:42 Cravings, mood, and resilience with sleep loss ... 00:08:49 Melissa Urban’s sleep disruption stories: motherhood, book tour, menopause ... 00:10:02 Sleep and technology: SleepBuds saving marriage ... 00:12:42 Sleep consistency as key for resilience and health ... 00:17:47 Chronic light sleep: cognitive and metabolic consequences ... 00:20:09 Hormonal disruption and menopause sleep challenges ... 00:24:42 Sleep refresh tips: environment and habits ... 00:26:07 Screen-free wind-down routines ... 00:27:41 Midlife sleep wisdom: earlier bedtime ... 00:34:37 Physical and mental benefits of good sleep ... 00:36:06 Noise canceling vs. masking: SleepBuds explained ... 00:39:18 Sleep supplements: magnesium, melatonin, CBD ... 00:48:28 One impactful habit: eliminate screens and alcohol ... 00:53:30 Where to find Melissa Urban and Ozlo ... 00:56:27 Our Amazing Sponsors: - A next-generation serum packed with three trillion PRP-derived exosomes and RejuvNAD™ to support collagen production and skin renewal at the cellular level—helping results build over time instead of fading fast. Shop at and use code NAT10 – A full-spectrum digestive enzyme formula with 4x more protease to help break down protein into usable amino acids so your body actually benefits from what you eat—try it risk-free with a 365-day money-back guarantee and save 15% at with code BIONAT. - These clinically researched gummies support mitophagy to help renew your mitochondria and boost cellular energy, giving you a stronger biological foundation for resilience—visit to get 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40556095

#425: Broccoli Power: The Secret Longevity Molecule (Fighting Toxins, Microplastics & Aging) | Sulforaphane Exposed With David Roberts & Dr. John Gildea 03/31/2026

#425: Broccoli Power: The Secret Longevity Molecule (Fighting Toxins, Microplastics & Aging) | Sulforaphane Exposed With David Roberts & Dr. John Gildea Today, I’m joined by , two passionate researchers whose work sits at the cutting edge of environmental health and longevity science. In this episode, we dive deep into the catalyst for developing a stabilized sulforaphane supplement—something born out of both necessity and relentless curiosity. David opens up about how environmental toxicity stopped being theoretical for him, and Dr. Gildea brings a wealth of clinical insight into why supporting our detox pathways could be a game-changer for chronic disease prevention. Offer: Get 25% off stabilized sulforaphane products for a limited time at with code NAT (offer ends April 7th 2026; 15% off thereafter). Episode Timestamps: Welcome and podcast intro ... 00:00:00 When toxins became personal: cancer & environment ... 00:04:54 Practical detox: household and lifestyle changes ... 00:06:12 Sulforaphane’s effect on inflammation and daily function ...00:07:07 Finding health solutions outside conventional medicine ... 00:14:44 Cancer diagnosis prompts sulforaphane stabilization ... 00:18:17 NRF2: master regulator in aging, skin, and detox ... 00:24:16 Sulforaphane, curcumin, and inflammation ... 00:25:11 Supplement confusion: sulforaphane vs. glucoraphanin ... 00:31:10 Food as medicine and practical dosing ... 00:34:51 Microplastics: exposure, health risks, and impacts ... 00:35:31 Detox routes and microplastics research ... 00:47:04 Glyphosate, NRF2 suppression, and gut barriers ... 00:52:54 Sulforaphane boosts detox and protects against pollution ... 00:59:13 GLP-1s, muscle loss risk, and supplement alternatives ... 01:00:08 Berberine: sleep, glucose, and microbiome effects ... 01:06:12 Synergies, future research, and sulforaphane limits ... 01:10:32 Sprouts, seeds, and potency of broccoli compounds ... 01:16:17 Our Amazing Sponsors: - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit and use code NAT20 for 20% off. – a fast-acting, customizable sleep formula designed to quiet racing thoughts and support deeper, more restorative sleep using a powerful blend of GABA-supporting compounds, cannabinoids, and sleep-promoting ingredients. Head to , use code NAT10, and get 10% off. by LVLUP Health - supports your liver’s natural detox pathways so your body can reset after the holidays without suffering. Go to and use code NAT for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40670095

#424: Part 2 - Follow Up To Dr. Bill Lawrence Episode: Answering More Of Your Bioregulator Questions With Nat Niddam & Erin Ryan 03/27/2026

#424: Part 2 - Follow Up To Dr. Bill Lawrence Episode: Answering More Of Your Bioregulator Questions With Nat Niddam & Erin Ryan Today, I’m joined by Erin Ryan, my producer, for a special follow-up episode where we tackle your most pressing questions about bioregulators and peptides. After the wildly popular Bill Lawrence interview, the Longevity Podcast community sent in a wave of thoughtful queries—from cancer concerns to menopause, sourcing, and practical tips. Books mentioned in this episode: (Great primer on bioregulators) Author: Dr. Marios Kyriazis (Technical, science-heavy) Author: , , Episode Timestamps: Welcome and sponsor introduction ... 00:00:00 Autophagy and Primadene ... 00:00:44 Bioregulator basics and liver support ... 00:01:58 Cancer and telomere lengthening peptides ... 00:05:56 Bioregulators and cancer: caution advised ... 00:08:06 Immune bioregulators and cancer recovery ... 00:12:31 Book reference: "Peptide Bioregulator Revolution" ... 00:13:54 Bioregulators for immune support ... 00:14:44 When not to use bioregulators ... 00:16:56 Menopause, ovarian aging, and bioregulators ... 00:17:47 Clinical outcomes in women ... 00:23:57 GLP-1s and bioregulator absorption ... 00:27:01 Preventative strategies by age ... 00:28:57 Epitalon safety and dosing ... 00:33:18 Bioregulator sourcing and access ... 00:35:41 Amazon caution for supplements ... 00:38:01 Emerging science and trusted brands ... 00:40:03 Social media challenges and newsletter ... 00:44:30 Our Amazing Sponsors: — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit and use code BIONAT20 at checkout. - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to and use code NAT15 for 15% off your first order. — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at and use code NAT15 for 15% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40541465

#423: Detox Pathways, Sensitive Systems, and the Truth About Chelation Therapy With Dr. Nafysa Parpia 03/24/2026

#423: Detox Pathways, Sensitive Systems, and the Truth About Chelation Therapy With Dr. Nafysa Parpia Today, I’m joined by the insightful , a true leader in environmental and complex chronic illness medicine and the Director of Naturopathic Medicine at Gordon Medical. In our conversation, Dr. Parpia shares how her passion for deep, integrated healing brought her into the world of environmental toxins, hormone health, and the nuanced ways our bodies respond to the modern world. She opens up about her journey, the unique challenges women face—especially during menopause—and why so many aren’t finding answers in traditional medicine. Episode Timestamps: Welcome & episode goals ... 00:00:00 Environmental toxins and complex illness ... 00:01:17 Rise of chronic illnesses; environmental triggers ... 00:07:26 Lead, bone loss, and menopause ... 00:10:03 Sources of lead exposure today ... 00:12:03 Chelation therapy: what, when, and how ... 00:14:26 Opening detox pathways: herbs and bioregulators ... 00:17:17 Menopause, toxic burden, and immune shifts ... 00:20:49 CDC data: multiple toxins and cumulative risk ... 00:23:02 Genetics, nutrition, and susceptibility ... 00:28:12 Personalized medicine & system constraints ... 00:30:03 Heavy metals, inflammation, and hormone effects ... 00:35:35 Peptide and bioregulator therapy: sequencing matters ... 00:41:12 Testing mistakes: over- and under-testing ... 00:57:41 Preparing for detox: the Pretox approach ... 01:02:58 Sensitivity to binders and protocol adjustments ... 01:16:50 Plasmapheresis (TPE): science and application ... 01:19:19 Optimizing menopause care and women’s self-sovereignty ... 01:25:28 Our Amazing Sponsors: - A plant-based formula designed to support your body’s natural stem cell release, circulation, and repair processes so you can recover and regenerate more effectively. Visit and use code NAT15 for your exclusive discount. — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at with code BIONAT — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours and use code Nat10 Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40339225

#422: Lessons from Centenarians: Immunity, Lifestyle, and Changing the Aging Game With Dr. Jeffrey Bland 03/20/2026

#422: Lessons from Centenarians: Immunity, Lifestyle, and Changing the Aging Game With Dr. Jeffrey Bland Today, I’m joined by the legendary , widely known as the “father of functional medicine” and a true pioneer in the science of longevity and immune resilience. In this conversation, Dr. Jeffrey Bland opens up about his decades-long journey questioning the conventional medicine model, the personal moments that shaped his mission, and how his passion for asking the right questions ultimately led him to reshape the future of healthcare. Visit and get 15% off automatically at checkout. Episode Timestamps: Focus on immune system aging ... 00:00:00 Questioning conventional medicine and the roots of chronic disease ... 00:05:00 Functional medicine and influences like Linus Pauling ... 00:12:39 Dangers of oversimplification and the limits of biohacking ... 00:17:21 Evolving thinking on supplements and the power of cycling and personalization ... 00:19:37 Why immune resilience trumps immune boosting for longevity ... 00:25:21 Diet’s impact on immune cell turnover and long-term health ... 00:28:57 Autoimmunity, CHIP cells, inflammaging, and biological individuality ... 00:32:04 Microbiome, mitochondria, and immune-driven fatigue ... 01:00:07 The 4R gut and immune program as a starting point ... 01:06:26 Movement, lymphatics, and rejuvenation ... 01:08:35 Food as information, epigenetics, and practical recommendations ... 01:11:25 90-day immune system renewal and rapid-fire takeaways ... 01:31:40 Our Amazing Sponsors: - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it’s easy to try for yourself. Visit and use code NAT15 to start the free 15 day trial. — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit and use code BIONAT20 at checkout. — A clean, high-quality whey protein that’s third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to and use code NAT for 32% off your first subscription or 20% off anything on the site. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40424030

#421: Trauma SCIENCE: How Hidden Stress Hijacks Your Health (Autoimmunity, Brain Inflammation, and Unlocking Resilience) | With Dr. Aimie Apigian 03/17/2026

#421: Trauma SCIENCE: How Hidden Stress Hijacks Your Health (Autoimmunity, Brain Inflammation, and Unlocking Resilience) | With Dr. Aimie Apigian Today, I’m joined by , an innovative leader in the biology of trauma, whose work bridges the worlds of science, medicine, and lived experience. In our conversation, Dr. Apigian opens up about her journey from conventional medicine—where symptom management was the norm—to uncovering the physiological roots of trauma and the crucial role our nervous system plays in resilience and healing. She shares how her own health struggles, her work with adopted children, and a relentless curiosity led her to re-examine everything she thought she knew about stress, autoimmunity, and capacity. The 7-Day Somatic Healing for Stored Emotions - 21-Day Journey, a daily live session program that helps participants understand how much trauma their body may be holding - Episode Timestamps: Introduction, host’s mission, and episode theme ... 00:00:00 Science behind trauma, limits of traditional medicine, and autoimmune experiences ... 00:06:11 Attachment, symptom management, functional medicine, and healing journey ... 00:08:17 Mold exposure, state triggers, brain inflammation, and capacity blocks ... 00:14:22 Medical gaslighting, trauma validation, and biological capacity ... 00:18:25 Safety, resilience, and chronic survival state effects ... 00:19:32 Misconceptions about chronic stress—emergency brake and vagus nerve ... 00:22:27 Attachment patterns, autoimmunity, and shrinking world ... 00:28:47 Chronic survival loop, exhaustion, coping strategies, and shutdown ... 00:31:11 Moving to repair: phases of healing and gentle approaches ... 00:34:08 Somatic practices, art therapy, and different expressions of trauma ... 00:39:01 Shifts in sleep, digestion, anxiety, and felt safety ... 00:42:06 Tracking nervous system state: strategies and awareness ... 00:46:41 Therapy limitations: biology and somatic integration ... 00:48:42 Retraining vs. managing symptoms, stabilization, and healing ... 00:54:53 Capacity, resilience, lessons from centenarians, and longevity ... 01:00:06 Trauma’s impact on mitochondria, telomeres, and generational health ... 01:06:27 Gut microbiome and trauma: two-way connection ... 01:08:03 Our Amazing Sponsors: - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to to save up to 31% plus $25 in free gifts with the Starter Kit. Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to for 20% off Mitopure Gummies. - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to and use code NAT to get $75 off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40327370

#420: Spermidine UNLOCKED: Reverse Aging, Boost Immunity & Thrive After 40 With Leslie Kenny 03/13/2026

#420: Spermidine UNLOCKED: Reverse Aging, Boost Immunity & Thrive After 40 With Leslie Kenny Today, I'm joined by the inspiring , Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable. Leslie has a generous offer for you, when you visit and use code BIONAT20 at checkout you’ll get 20% off. Episode Timestamps: Welcome, show intro, and overview ... 00:00:00 Leslie Kenny’s health journey and reversing disease ... 00:00:30 Biological vs. chronological age and the immune system ... 00:04:55 Impact of trauma and stress on aging ... 00:11:51 Overcoming prognosis: lifestyle and scientific interventions ... 00:18:02 Diet, tracking, and removing triggers ... 00:22:21 The overlooked importance of thyroid health ... 00:32:23 Dangers of overdoing fasting and hormesis ... 00:40:21 Autophagy basics and the cellular cleanup crew ... 00:44:06 Spermidine’s role, sourcing, and supplement quality ... 01:10:19 Optimizing longevity habits and daily routines ... 01:29:44 Our Amazing Sponsors: – A fast-acting sleep troche that dissolves in your cheek and combines melatonin with compounds like honokiol, adenosine, cordycepin, CBD, CBN, and 5-HTP to support deep, restorative sleep when travel, stress, or late workouts throw things off. Head to and use code NAT10 for 10% off your first order. - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at with code NAT20. - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to http://www.profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40323805

#419: A Mind-Blowing Mitochondria Episode— Mito Transplant, Rare Diseases & Biomarkers With Dr. Natalie Yivgi-Ohana 03/10/2026

#419: A Mind-Blowing Mitochondria Episode— Mito Transplant, Rare Diseases & Biomarkers With Dr. Natalie Yivgi-Ohana Today, I’m joined by the extraordinary , a pioneering scientist whose passion for mitochondria unlocks new frontiers in longevity medicine. Our conversation truly blew my mind—Dr. Yivgi-Ohana brings decades of expertise to demystify these tiny, ancient powerhouses that fuel every cell in our bodies, impact our hormones, drive immunity, and, as it turns out, play a central role in how we age. Episode Timestamps: Welcome to the Longevity Podcast and today's focus on mitochondria ... 00:00:00 Maternal inheritance and critical functions of mitochondria ... 00:05:56 Mitochondria as energy producers and hormone regulators ... 00:07:03 Aha moments: mitochondria control life, death, and disease ... 00:08:55 Endosymbiotic theory: how mitochondria originated ... 00:10:19 Chronic disease, aging, and the connection to mitochondria ... 00:16:10 Substrate fuels: carbs, fats, and importance of metabolic flexibility ... 00:20:18 Mitochondria’s control over immune system and signaling ... 00:26:39 Mitochondrial transfer: how cells share organelle “powerhouses” ... 00:32:42 Groundbreaking therapy: transplanting mitochondria for rare diseases ... 00:36:40 Expanding mitochondrial therapies to age-related diseases ... 00:42:57 Aging in women: hormones, mitochondria, and inflection points ... 00:51:00 Stem cell exhaustion and cellular renewal ... 00:52:24 Biomarkers: ways to measure mitochondrial health ... 01:03:11 Supplements, lifestyle, and emotional health for mitochondria ... 01:15:47 Medication choices and minimizing mitochondrial toxicity ... 01:24:04 Our Amazing Sponsors: — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at and use code NAT15 for 15% off. — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at with code BIONAT - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit and use code NAT20 for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40185535

#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum 03/06/2026

#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum Today, I’m joined by the insightful Courtney Van Bussum, a biomedical engineer and entrepreneur who has become a rising force in longevity science. Courtney shares how growing up in a family of healthcare innovators shaped her journey, and how she pivoted from startup life to tackling age-related challenges—especially when COVID brought her back to her roots and reignited her passion for cellular health. If you want to try Endotelio 1-MNA and save 10% and code NAT10 will be entered for you at checkout. Episode Timestamps: Welcome and introduction to Longevity Podcast ... 00:00:00 Challenging beliefs about aging and cellular health ... 00:12:00 Deep dive into NAD+ biochemistry and cellular function ... 00:13:08 NAD+/NADH balance: Why both matter ... 00:15:24 Why NAD+ declines: Not just aging, but increased degradation ...00:18:26 The role of CD38 and NMNT enzymes in NAD metabolism ... 00:20:14 Controversy and confusion: NAD+ precursors (NR, NMN) and IVs ... 00:22:28 Methylation’s hidden importance in NAD supplementation ... 00:30:55 Supplementing 1-MNA: Understanding dosages and applications ... 00:50:54 Assessing NAD+ status: Biomarkers and limitations of testing ... 00:53:01 Lifestyle ROI: Sleep, exercise, and circadian rhythm for NAD preservation ... 00:57:14 Ketones: Beyond performance, supporting cellular energy and longevity ... 01:06:03 Future of NAD science: Anticipating new insights and risks ... 01:11:45 Confidence and humility: Advice for navigating the longevity field ... 01:18:52 Our Amazing Sponsors: – A clinically formulated blend of two highly bioavailable forms of creatine plus magnesium and electrolytes to support lean muscle, cellular energy, and brain health—especially for women over 40 who naturally produce less with age. Go to and use code NATHALIE to save up to 50%, plus an additional 15% off. by LVLUP Health - supports your liver’s natural detox pathways so your body can reset after the holidays without suffering. Go to and use code NAT for 20% off. – This powerhouse duo pairs the only probiotic clinically proven to arrive 100% alive in your gut with science-backed Digestive Bitters to reduce bloat, curb cravings, and support better energy fast. Take the Just Thrive Feel Better Challenge and save 20% at with code NAT20. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40185510

#417: Depression and Weight Gain In Kids & Adults | A Long Term Post-COVID Problem & How To Reverse It With Dr. Cynthia Keller 03/03/2026

#417: Depression and Weight Gain In Kids & Adults | A Long Term Post-COVID Problem & How To Reverse It With Dr. Cynthia Keller Today, I’m joined by the innovative , a pediatrician whose passion for integrative and functional medicine has reshaped how we understand post-COVID health challenges. Dr. Keller opens up about her journey from conventional medicine to designing unique solutions for children and families, revealing how her care, presence, and determination to “solve the unsolvable” led to breakthroughs in treating mood changes, weight gain, and energy loss after COVID. Special Offer: If you go to and use code NatRocks at checkout, you’ll get a whopping 50% off of the Tryptophan Re-Genesis™ Powder while supplies last! (Capsules not included). Episode Timestamps: Introduction and host’s mission ... 00:00:00 From standard care to integrative pediatrics ... 00:05:05 Patterns in pediatric development and disease ... 00:09:19 Gut health, emotional factors, and parenting ... 00:10:44 Clinic model and multidisciplinary care ... 00:15:04 Post-COVID nutrient depletion: clinical discoveries ... 00:18:03 Key depleted cofactors and rapid recovery ... 00:19:31 COVID’s ongoing impact on gut and microbiome ... 00:24:39 Grassroots collaboration and evolving strategies ... 00:26:28 Clinical patterns: mood, weight, thirst ... 00:36:02 Family-wide interventions and quick results ... 00:46:24 Symptoms-based approach, minimal testing ... 00:52:07 Supplementation protocol and cautions ... 00:57:14 Product development and access ... 01:08:22 Infant microbiome and generational shifts ... 01:10:28 Pediatricians: importance of listening and presence ... 01:20:09 Love and connection in clinical care ... 01:21:01 Modern dysregulation: loss of boredom ... 01:22:28 Our Amazing Sponsors: - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to and use code NAT to get $75 off. — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours at and use code Nat10 for first orders or and code 5NAT for returning customers. Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to for 20% off Mitopure Gummies. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40184525

#416: The Cardiovascular Crisis No One Talks About: Women, Midlife & Nitric Oxide Explained With Cathy Eason 02/27/2026

#416: The Cardiovascular Crisis No One Talks About: Women, Midlife & Nitric Oxide Explained With Cathy Eason Today, I’m joined by the remarkable , whose work in the and vascular health space is changing the conversation around resilience and heart health for midlife women. Cathy dives into why cardiovascular disease is still the number one threat to women globally, and how the drop in estrogen during menopause impacts nitric oxide production—an overlooked factor that quietly influences everything from energy to cognition. Visit and use code NAT20 for 20% off. Episode Timestamps: Podcast welcome and cardiovascular focus ... 00:00:00 Introducing Cathy Eason, nitric oxide updates ... 00:03:26 Menopause as a vascular event ... 00:08:50 Everyday signs of cardiovascular decline ... 00:11:19 Body awareness and tracking health metrics ... 00:14:15 Healthy labs but low resilience ... 00:16:56 Defining and understanding menopause ... 00:22:48 Systems affected during menopause ... 00:25:26 Nitric oxide’s critical role ... 00:44:24 Testing and optimizing blood flow ... 00:48:14 Value of health patterns over labs ... 00:55:09 Communicating health trends to providers ... 00:56:32 Berkeley Life supplement recommendation ... 00:59:02 Prioritizing basic health habits ... 01:01:58 Longevity reframe: thriving with age ... 01:06:46 Advice for early action ... 01:07:09 Our Amazing Sponsors: — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit and use code BIONAT20 at checkout. — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at with code BIONAT - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to and use code NAT15 for 15% off your first order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40071340

#415: Bioregulator Questions Answered: Follow Up To Dr. Bill Lawrence Episode With Nat Niddam 02/24/2026

#415: Bioregulator Questions Answered: Follow Up To Dr. Bill Lawrence Episode With Nat Niddam Today, I’m joined by Erin Ryan, my producer and long-time collaborator, for a special Q&A episode powered entirely by your questions. After our bioregulator deep dive with Dr. Bill Lawrence, the response was overwhelming—so many of you reached out with insightful queries about bioregulators, peptides, and the nuances between natural and synthetic options. Erin and I decided to tackle the most common themes, unpacking everything from organ versus system signaling to how bioregulators actually survive digestion. Nat’s favorite Bioregulators: and use code NAT15 for 15% off your first order. and use code NAT10 for 10% off. and click “shop” and use code NAT for 10% off. Episode Timestamps: Episode introduction and Q&A format ... 00:00:00 Natural vs. synthetic bioregulators ... 00:08:24 Peptide signaling and digestion ... 00:11:35 Brand reliability and BPC-157 oral benefits ... 00:20:18 Organ/system signaling basics ... 00:25:42 Bioregulator priorities and cycle protocols ... 00:29:51 Healthy, preventative, and age-related use ... 00:38:44 Are organ meats enough? Food vs. supplements ... 00:41:46 Clinical evidence and biggest impact ... 00:47:57 Resilience, wrap-up, and sourcing info ... 00:52:09 Our Amazing Sponsors: - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to and use code NAT to get $75 off. - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit and use code NAT20 for 20% off. — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at and use code NAT15 for 15% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40149520

#414: The Untold Truth About Heart Health: (Women, Genetics & the JOY of Longevity) | Dr. Regina Druz Reveals All 02/20/2026

#414: The Untold Truth About Heart Health: (Women, Genetics & the JOY of Longevity) | Dr. Regina Druz Reveals All Today, I’m joined by the trailblazing , a cardiologist who reimagined heart health after years in elite academic medicine. In this episode, opens up about her journey from the traditional halls of Cornell and New York Presbyterian to creating truly personalized, preventive, and holistic programs for her patients—even when it meant leaving behind the medical mainstream. Episode Timestamps: Podcast intro and Dr. Druz’s background ... 00:00:00 The value of female perspectives in cardiology ... 00:04:11 Moving from traditional to integrative cardiology ... 00:13:17 Upsides of personalization vs. “fire and forget” ... 00:22:15 Prevention through personalized genetics ... 00:26:11 Population vs. individual risk and aging ... 00:38:05 Impact of genetics and nutrition on heart health ... 00:45:07 Healthcare’s prevention gap ... 00:48:38 Deeper causes: treating the “why,” not just blocked arteries ... 00:50:18 Screening earlier and understanding vascular age ... 01:05:30 Epicardial fat, inflammation, and menopause’s impact ... 01:10:39 Wearables, AI, and the future of cardiology ... 01:22:18 Heart-brain connection: stress, trauma, and longevity ... 01:26:35 Our Amazing Sponsors: – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at with code LONGEVITY for up to 20% off, and don’t forget to mention this podcast in the post-purchase survey. — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at with code BIONAT by LVLUP Health - supports your liver’s natural detox pathways so your body can reset after the holidays without suffering. Go to and use code NAT for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40022825

#413: Mold, Toxins, and the Cell Danger Response: How to Reclaim Energy and Resilience With Dr. Clement Lee, NMD 02/17/2026

#413: Mold, Toxins, and the Cell Danger Response: How to Reclaim Energy and Resilience With Dr. Clement Lee, NMD Today, I’m joined by the thoughtful , a naturopathic doctor blending ancient wisdom from Chinese medicine with cutting-edge regenerative therapies. In this episode, Dr. Lee gets real about why people can feel deeply unwell long before anything shows up on standard labs—and how subtle issues like limbic system stress, toxins, and chronic inflammation quietly undermine our vitality. Episode Timestamps: Welcome and episode overview ... 00:00:00 Prolotherapy, Chinese medicine, and complex healing cases ... 00:05:16 Common misconceptions in chronic illness treatment ... 00:13:15 Why mindset and the limbic system affect healing ... 00:18:02 Early warning signs of chronic illness ... 00:22:50 Evaluating toxins, hormones, and inflammation in root cause medicine ... 00:26:03 Toxic overload concerns in children ... 00:27:09 First steps for chronic, hard-to-treat cases ... 00:31:56 Top interventions for longevity now ... 00:33:43 Testing for heavy metals and toxins ... 00:35:12 Inflammation loops and surprising causes like mold ... 00:38:12 The role of cellular healing and the nervous system ... 00:47:09 Advanced therapies: peptides, IV nutrients, and more ... 00:52:01 Mast cell activation and immune overdrive signals ... 01:08:23 Key takeaways and easy strategies for stress ... 01:26:40 Our Amazing Sponsors: Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to for 20% off Mitopure Gummies. - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at with code NAT20. — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours at and use code Nat10 for first orders or 5NAT for returning customers. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40022815

#412: From Anti-Aging to Age Reversal: The Exosome & Copper Peptide Breakthrough For Younger Skin With Debbi Barber and Dr. Jordan Plews 02/13/2026

#412: From Anti-Aging to Age Reversal: The Exosome & Copper Peptide Breakthrough For Younger Skin With Debbi Barber and Dr. Jordan Plews Today, I’ve got a conversation that goes deep into the cutting edge of regenerative skin health with two exceptional guests: Debbi Barber, founder and muse of , and Dr. Jordan Plews, a biochemical engineer and stem cell researcher. We discuss the science and practical realities of exosomes, stem cells, and copper peptides—breaking down not just what makes skin look younger, but what truly keeps it biologically healthier and more resilient as we age. Visit and use code Nat20 Episode Timestamps: Welcome and podcast purpose ... 00:00:00 Shift from beauty to science and health ... 00:09:23 GHK-Cu’s role in longevity and skin repair ... 00:10:15 Dr. Plews on regenerative medicine and stem cells ... 00:11:14 From peptides to exosomes: product evolution ... 00:13:35 Stem cell exhaustion and need for exosome signaling ... 00:14:07 Copper peptides vs. exosomes: complementary actions ... 00:18:00 Why source and age of exosomes matter ... 00:25:20 Quality, safety, and labeling in exosome products ... 00:35:01 How exosomes and peptides benefit skin deeper layers ... 00:44:35 Visible results: barrier, redness, scars, texture ... 00:58:05 What to expect: younger vs. older skin ... 01:00:01 Proof and stories: customer transformations ... 01:01:59 More isn’t better: exosome dosing myth ... 01:07:03 Supporting ingredients: vitamin C, glutathione, SOD2 ... 01:11:31 Skin as a window into systemic aging ... 01:19:08 The future: personalized, organ-targeted exosome therapies ... 01:24:02 Our Amazing Sponsors: - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to and use code NAT15 for 15% off your first order. - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to to save up to 31% plus $25 in free gifts with the Starter Kit. — A clean, high-quality whey protein that’s third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to and use code NAT for 32% off your first subscription or 20% off anything on the site. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/40022760

#411: Rethinking Heart Health: Surrender, Sunlight, and Structured Water With Dr. Stephen Hussey 02/10/2026

#411: Rethinking Heart Health: Surrender, Sunlight, and Structured Water With Dr. Stephen Hussey Today, I’m joined by —a clinician, author of , and a powerful force in rethinking everything we thought we knew about heart disease. Dr. Hussey’s own journey began with type 1 diabetes as a child, and despite living a healthy, active lifestyle, he experienced a widowmaker heart attack at just 34 years old. In our conversation, he opens up about what it was like to face this crisis with “perfect” lab numbers, how it challenged his entire perspective, and ultimately led him to a radical new understanding of heart health and longevity. Episode Timestamps: Podcast introduction and heart disease focus ... 00:00:00 Dr. Stephen Hussey’s health story and diabetes management ... 00:04:16 Heart attack, hospital experience, and challenging cholesterol dogma ... 00:15:04 How Dr. Hussey reversed arterial plaque ... 00:21:47 Rethinking heart function: vortex vs. pump ... 00:24:17 Structured water, hydration, and blood flow ... 00:36:39 Sunlight, grounding, and circadian rhythm for heart health ... 00:46:13 Impact of EMFs on blood and cellular energy ... 01:01:03 Actionable strategies to future-proof your heart ... 01:08:17 Trauma and emotional health in longevity ... 01:10:14 Evaluating your healthcare team holistically ... 01:12:28 Dr. Hussey’s philosophy on nature and letting go ... 01:21:05 Closing thoughts and how to find Dr. Hussey ... 01:28:14 Our Amazing Sponsors: – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at with code LONGEVITY for up to 20% off, and don’t forget to mention this podcast in the post-purchase survey. — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at and use code NAT15 for 15% off. - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit and use code NAT20 for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39894155

#410: Reversing Burnout: Turmeric, Gut Health, and Circadian Rhythms Explained With Shivani Gupta 02/06/2026

#410: Reversing Burnout: Turmeric, Gut Health, and Circadian Rhythms Explained With Shivani Gupta Today, I’m joined by the wonderful Dr. Shivani Gupta, a true force in bridging ancient Ayurvedic wisdom with cutting-edge modern research on inflammation and healthy aging. She recently authored The Inflammation Code. Dr. Shivani opens up about her deeply personal motivation—from witnessing her grandfather’s preventable health decline to spending years in both traditional and scientific studies, ultimately earning a PhD focused on turmeric and chronic inflammation. For Dr. Shivani’s Turmeric and sleep gummies visit and use code NAT15 for 15% off. Episode Timestamps: Welcome & Introduction to Longevity Podcast ... 00:00:00 Autophagy & Spermidine Supplementation ... 00:02:41 Personal Connection & Product Experience ... 00:03:46 Health Declines in Modern Indian Culture ... 00:07:47 Reversing Disease: Ayurveda & Biohacking ... 00:11:11 Discovering Ayurveda & Turmeric’s Power ... 00:15:12 Turmeric vs. NSAIDs: Scientific Support ... 00:19:52 PPIs, Gut Health, and Curcumin ... 00:21:26 Inflammation as the Root of Chronic Disease ... 00:23:24 Sleep Rituals & Circadian Timing ... 00:28:59 Elemental Design / Doshas Explained ... 00:32:13 Aligning Lifestyle with Dosha for Health ... 00:42:46 Mental Inflammation: Stress & Burnout ... 00:46:00 Turmeric Science, Uses & Myths ... 00:54:20 Personalized Spice Use & Dosha Guidance ... 01:03:48 Top Spices for Longevity ... 01:07:44 Cautions: Medications & Turmeric ... 01:10:03 The Future of Inflammation in Medicine ... 01:11:11 Rapid-Fire Longevity Habits ... 01:15:03 Our Amazing Sponsors: by LVLUP Health - supports your liver’s natural detox pathways so your body can reset without suffering. Go to and use code NAT for 20% off. — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit and use code BIONAT20 at checkout. — A powerful duo of a clinically proven probiotic and digestive bitters to reduce bloat, boost energy, curb cravings, and help you feel your best fast, backed by a 100% money-back guarantee — Take the Feel Better Challenge and save 20% at with promo code NAT20. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39860885

#409: How to LIVE YOUNG for a Lifetime: The Real Secrets of Mindset, Medicine & Longevity | Personalized Health Explained With Dr. Jeffrey Gladden 02/03/2026

#409: How to LIVE YOUNG for a Lifetime: The Real Secrets of Mindset, Medicine & Longevity | Personalized Health Explained With Dr. Jeffrey Gladden Today, I’m joined by the inspiring —a trailblazer in longevity medicine who once spent decades as an interventional cardiologist, only to challenge everything he knew after his own health hit a wall. Dr. Gladden opens up about the moment he refused to accept “normal for your age” as a diagnosis, launching himself into the world of functional and age-management medicine to reclaim his vitality and help others do the same. Episode Timestamps: Welcome and episode introduction ... 00:00:00 Health crisis and discovering personal optimization ... 00:07:05 From “sick care” to health optimization ... 00:10:46 Vision for personalized, youthful longevity ... 00:12:17 Personalized medicine: why one size doesn’t fit all ... 00:16:00 Linear versus exponential aging; fixing a flawed approach ... 00:18:02 Five circles of exponential health: key longevity domains ... 00:19:23 Curiosity, growth mindset, and quantum thinking in longevity ... 00:22:22 Why individualization is crucial for diet and interventions ... 00:28:52 Insulin resistance: the hidden driver of aging ... 00:33:41 Environmental and internal (psychospiritual) factors in health ... 00:38:40 Healing through meditation, stress management, and flow ... 00:41:15 Robustness, resilience, and anti-fragility as longevity superpowers ... 00:57:09 Safe, personalized hormone therapy and the importance of tracking ... 01:03:33 Integrating mindset, purpose, and psycho-spiritual work ... 01:08:50 Peptides and advanced therapies: preparing for optimal results ... 01:09:56 Common test misconceptions in longevity medicine ... 01:12:56 Debunking the myth of single biological age ... 01:16:38 Resources, connect with Dr. Gladden, and closing ... 01:18:09 Our Amazing Sponsors: by Young Goose — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours at and use code Nat10 for first orders or 5NAT for returning customers. - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it’s easy to try for yourself. Visit and use code NAT10 to start the free trial. Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to for 20% off Mitopure®️ Gummies. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39838295

#408: The Surprising Truth About Metabolomics, Stress, and Slowing Aging (Peptides, Heavy Metals & Foundational Health Secrets) With Gus Vickery 01/30/2026

#408: The Surprising Truth About Metabolomics, Stress, and Slowing Aging (Peptides, Heavy Metals & Foundational Health Secrets) With Gus Vickery Today, I’m sitting down with , a good friend and one of my favorite collaborators when it comes to cutting-edge insights in personalized health and longevity. In this episode, I put myself under the microscope as we walk through my own metabolomics testing after a period of heavy travel, stress, and—yes—a break from my usual supplement routine. If you’ve ever wondered whether skipping your foundational health habits “just for a little while” really matters, you’re about to find out. If you are a clinician and would like to offer the Aristotle test to your patients please use this link to learn more about the Theriome test: If you are a patient and would like to run the Theriome Aristotle test and get a full interpretation and protocol based on your results from Dr Vickery & his team please use this link: Episode Timestamps: Introduction to Longevity Podcast and episode overview ... 00:00:00 Metabolomics and interpreting health data – practitioner guidance needed ... 00:05:05 Combining metabolomics, gut, and blood data for whole-system insights ... 00:06:02 Nutrient depletion and oxidative stress: critical findings ... 00:18:57 Supplementation essentials for aging well ... 00:27:05 Metabolomics comparison by age group and optimization goals ... 00:29:03 Stacking interventions: why less is more with diagnostics ... 00:31:05 Functional health markers and the value of context ... 00:34:47 Sympathetic dominance, mindset, and impact on longevity ... 00:35:26 Restoring nervous system balance – inner work and tech tools ... 00:42:38 Toxins, heavy metals, and practical detox strategies ... 00:49:11 Clean environment, resiliency, and realistic lifestyle shifts ... 00:55:29 Key nutrient deficiencies revealed by metabolomics ... 01:09:15 Genetic and metabolomic tests: what’s actionable? ... 01:15:07 Hope for the future: human resilience and expanding technology ... 01:22:24 Weekly actionable: walk outside for mitochondria and stress relief ... 01:26:55 Our Amazing Sponsors: – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at with code LONGEVITY for up to 20% off, and don’t forget to mention this podcast in the post-purchase survey. - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to and use code NAT15 for 15% off your first order. from Young Goose brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, “Hey, start making that collagen again!” It’s longevity science, not cosmetic hype. Visit —use code NAT10 to get started, or 5NAT if you’re an existing customer. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39827550

#407: How MUSCLE Changes Everything: The Secret Organ of Longevity | Why “Healthy Sedentary” Is a Myth (and What To Do Instead) With Dr. Gabrielle Lyon 01/27/2026

#407: How MUSCLE Changes Everything: The Secret Organ of Longevity | Why “Healthy Sedentary” Is a Myth (and What To Do Instead) With Dr. Gabrielle Lyon Today, I’m joined by the remarkable , a pioneer in redefining the longevity conversation by making muscle health—not weight—the centerpiece of aging well. With a background in geriatrics and nutritional sciences, she illuminates why the quality of your muscle tissue is a far more powerful predictor of health than any number on the scale. Her perspective challenges the notion of a “healthy sedentary person” and reveals the major role of intramuscular fat in metabolic dysfunction. Check out her book . Episode Timestamps: Introduction, podcast focus, and welcoming Dr. Gabrielle Lyon ... 00:00:00 Muscle's impact on brain health, inflammation, and healthy aging ... 00:01:03 Dr. Lyon's childhood, grit, and self-discipline ... 00:04:33 Mentorship and protein science under Dr. Donald Lehman ... 00:07:05 Muscle as the overlooked metabolic organ ... 00:08:45 Why intramuscular fat matters more than body weight ... 00:10:06 Plant vs. animal protein for muscle health ... 00:13:29 Muscle as an endocrine organ and cognition ... 00:16:21 Future of muscle science: anabolics, imaging, and technology ... 00:18:22 GLP-1s, sarcopenic obesity, and muscle-first protocol ... 00:46:45 Sarcopenia, aging, and the importance of early training ... 01:04:35 Building lifelong resilience—mental and physical ... 01:08:31 Predictions: anabolics, muscle testing, and assessment ... 01:12:17 "Strength is a responsibility, not a luxury" ... 01:13:53 Our Amazing Sponsors: – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at with code LONGEVITY for up to 20% off, and don’t forget to mention this podcast in the post-purchase survey. - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to and use code NAT to get $75 off. by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It’s not a knockout pill; it’s a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit and use code NAT15 for 15% off. Sleep smarter, not harder. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39731770

#406: Peptide OVERLOAD: When Biohacking Backfires (How NOT to Crash Your Mitochondria) With Anthony Castore 01/23/2026

#406: Peptide OVERLOAD: When Biohacking Backfires (How NOT to Crash Your Mitochondria) With Anthony Castore Today, I’m joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators. Use code NAT10 for 10% off products at Episode Timestamps: Welcome and episode introduction ... 00:00:00 Anthony Castore’s path from strength coaching to cellular medicine ... 00:05:55 Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27 Explaining and balancing AMPK and mTOR for performance ... 00:13:03 Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18 Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04 Assessing recovery capacity and individualizing protocols ... 00:26:02 Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57 Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00 Differentiating bodybuilder vs. longevity approaches ... 00:34:44 Integrating peptides and support molecules into routines ... 00:40:44 Ketone esters and mitochondrial peptide interventions ... 00:41:20 Cautions on stacking and combining interventions ... 00:54:04 Lessons learned from overdoing interventions ... 01:05:02 Our Amazing Sponsors: - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit and use code NAT20 for 20% off. - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at with code NAT20. by LVLUP Health - supports your liver’s natural detox pathways so your body can reset after the holidays without suffering. Go to and use code NAT for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39733090

#405: Heart Attacks Aren’t What You Think | The Plaque LIE That Changes Everything (Cardiology 2.0) With Dr. Sanjay Bhojraj 01/20/2026

#405: Heart Attacks Aren’t What You Think | The Plaque LIE That Changes Everything (Cardiology 2.0) With Dr. Sanjay Bhojraj Today, I’m joined by the deeply thoughtful and refreshingly honest , a self-described “curious cardiologist” who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it? Episode Timestamps: Welcome to Longevity & episode setup … 00:00:00 Dr. Bhojraj’s shift from ER cardiology to prevention … 00:06:30 Why most heart attacks aren’t caused by big blockages … 00:09:15 Stress, nervous system load & heart attack risk … 00:13:10 CIMT explained: what it measures (and what it misses) … 00:26:40 Calcium scores vs CT angiograms … 00:35:45 CLEERLY scan: seeing dangerous soft plaque … 00:38:45 Can plaque actually regress? … 00:41:55 When heart scans make patients less afraid … 00:44:05 When should you test — even without symptoms? … 00:45:50 Why age 45 is a major cardiovascular inflection point … 00:47:10 Hormones, estrogen loss & women’s heart risk … 00:50:10 Why cardiology still misunderstands women … 00:54:30 Small dense LDL, ApoB & oxidized cholesterol … 01:02:00 Why fixing inflammation matters more than numbers … 01:05:50 Our Amazing Sponsors: - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it’s not just “healthy aging” in theory. Go to and use code NAT25 to save 25% are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. Get 35% off a one-month subscription at *Special deal through January 2026. — A clean, high-quality whey protein that’s third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to and use code NAT for 32% off your first subscription or 20% off anything on the site. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39627925

#404: The Dirty Truth About Your Home’s WATER (And Why Most Filters Including Reverse Osmosis Don’t Cut It) With Charles Bohdy and Victor Sagalovsky 01/16/2026

#404: The Dirty Truth About Your Home’s WATER (And Why Most Filters Including Reverse Osmosis Don’t Cut It) With Charles Bohdy and Victor Sagalovsky Today, I’m joined by , a true innovator in , and Victor Sagalovsky, a passionate advocate for bringing the science of water quality into our daily lives. Together, we take a deep dive into the unseen world of the water running through our homes—exploring not just its purity, but its hidden potential to support our biology in ways most of us have never considered. - Use code NAT100 Episode Timestamps: Intro to Longevity Podcast and today’s water focus ... 00:00:00 Water system’s health benefits and testing ... 00:01:33 Why water quality is overlooked yet critical ... 00:07:20 Common water issues and municipal limitations ... 00:09:10 Filtration methods: carbon blocks and pathogens ... 00:15:26 Charles’s nano-ceramic multilayer filters ... 00:20:14 Concerns with chlorine and fluoride in water ... 00:23:44 Retaining healthy minerals: charge-based filtration ... 00:35:18 Reverse osmosis: pros, cons, and fungal risks ... 00:50:49 Structured water’s role in biological health ... 00:56:53 Water structuring: agricultural validation ... 01:00:21 Whole-home filtration: installation and costs ... 01:11:02 Closing thoughts: bringing nature’s water home ... 01:25:00 Our Amazing Sponsors: - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it’s not just “healthy aging” in theory. Go to and use code NAT25 to save 25% by Oxford Healthspan: Primeadine supports autophagy — your cells’ natural renewal and cleanup process — using food-derived spermidine, no fasting required. If you want to support resilience from the inside out, head to and use code BIONAT20 at checkout (one-time purchases only). - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to and use code NAT to get $75 off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39575155

#403: What’s REALLY In Your Food? | Dark Secrets of Ultra-Pasteurized Milk, Natural Flavors & Microplastics EXPOSED With Ben Katz 01/13/2026

#403: What’s REALLY In Your Food? | Dark Secrets of Ultra-Pasteurized Milk, Natural Flavors & Microplastics EXPOSED With Ben Katz Today, I’m joined by Ben Katz—better known online as —an academic analytical chemist from UC Irvine whose mission is to uncover what’s really in our everyday foods, drinks, and products. Ben reverse engineers everything from Taco Bell meat to Doritos, and sometimes even entire industries, using cutting-edge mass spectrometry. His curiosity and expertise have made him a go-to source for those wanting to know what’s hiding behind vague ingredient labels and “natural flavors.” Episode Timestamps: Welcome and podcast introduction ... 00:00:00 What is mass spectrometry? ... 00:05:00 Viral "what’s in it?" projects and public interest ... 00:07:27 Synthetic vs. plant-derived nicotine and toxins in plant extracts ... 00:09:53 Food label transparency and loopholes (natural flavors, FEMA, GRAS) ... 00:20:11 Sweeteners & artificial additives: sucralose, stevia, cost motivations ... 00:23:07 Ultra pasteurization of milk and added flavors ... 00:29:48 Chocolate, caffeine content, and labeling challenges ... 00:33:12 Industrial food processes, GMOs, and food security insights ... 00:38:36 Microplastics: occurrence, regulation, and PEG in food ... 00:50:15 Supplements under development for microplastic removal ... 00:58:43 Adulteration in olive oil, maple syrup, and honey ... 01:04:08 Hidden sweeteners, and processed food pitfalls ... 01:10:14 Avoid artificial sweeteners, problematic plastics, and hidden flavors ... 01:14:36 Our Amazing Sponsors: - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to to save up to 31% plus $25 in free gifts with the Starter Kit. - uses seven absorbable forms of magnesium to support deeper sleep, calmer nerves, and real recovery. Get up to 35% off at with code BIONAT. - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to and use code NAT15 for 15% off your first order. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39565250

#402: Gut Reset: The SECRET Signals for Longevity Revealed | How to Heal Your Microbiome, Banish Bloating, and Build Resilience With Nat Niddam 01/09/2026

#402: Gut Reset: The SECRET Signals for Longevity Revealed | How to Heal Your Microbiome, Banish Bloating, and Build Resilience With Nat Niddam Today, I’m kicking off the new year with a back-to-basics deep dive into one of the most pivotal yet overlooked foundations of longevity: gut health. Over the past episodes, we’ve explored everything from gene therapy to advanced tech, but it all comes back to the habits and systems we rely on every single day—and the gut is right at the center of that equation. Episode Timestamps: Gut health as the cornerstone of longevity ... 00:00:00 Why disease and wellness begin in the gut ... 00:03:46 Symptoms and signs of gut imbalance ... 00:08:53 Normalizing digestive discomfort ... 00:09:33 Key stressors for gut health: stress, poor food choices ... 00:12:03 How chronic stress disrupts digestion ... 00:12:59 Processed foods, toxins, and nutrient deficiencies ... 00:13:14 The importance of whole foods, healthy fats, and cooked veggies ... 00:14:27 Testing and understanding your own food tolerances ... 00:16:31 Risks of dehydration, overtraining, and PPIs ... 00:19:24 Structure of a healthy gut: digestion, gut barrier, organ support ... 00:23:19 Pre-meal rituals for better digestion ... 00:25:33 Choosing and introducing probiotics and fiber ... 00:37:44 Tracking your food and gut motility ... 00:42:12 Lifestyle habits: exercise, sleep, stress, meal timing ... 00:45:00 Avoiding snacking and late meals ... 00:49:05 Remove offenders, restore with enzymes, replenish with probiotics ... 00:50:12 Bone broth, anti-inflammatory foods, and gut repair ... 00:54:19 Peptides and bioregulators for organ optimization ... 00:57:03 Our Amazing Sponsors: - a multi-pathway sleep support from Wizard Sciences. It’s not a knockout pill; it’s a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit and use code NAT15 for 15% off. Sleep smarter, not harder. by LVLUP Health - supports your liver’s natural detox pathways so your body can reset after the holidays without suffering. Go to and use code NAT for 20% off. - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit and use code NAT20 for 20% off. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39564085

#401: Personalization Is EVERYTHING: The New Science of Weight Health, GLP-1s, and Building Lasting Longevity With Ashley Koff 01/06/2026

#401: Personalization Is EVERYTHING: The New Science of Weight Health, GLP-1s, and Building Lasting Longevity With Ashley Koff Today, I’m joined by the insightful , renowned registered dietitian and fierce advocate for personalized, realistic nutrition that actually works in the real world. In this episode, Ashley Koff opens up about her personal and professional journey—from her early days in big brand marketing (think sugared cereals and infobesity) to her pivotal “aha” moments that led her to champion true weight health, not just weight loss. Episode Timestamps: Welcome and introduction to the Longevity Podcast ... 00:00:00 Personal experiences shaping nutrition philosophy ... 00:05:59 Influence of marketing on nutrition decisions ... 00:09:01 Big revelations: digestion, GLP-1, and health ... 00:16:43 The power of personalization in nutrition ... 00:19:59 The “Mr. Pizza Pop” case and behavioral change ... 00:23:03 Digestion as the foundation before diet quality ... 00:27:05 Dangers of generic “healthy diet” advice ... 00:36:01 GLP-1 medications: promise, risks, and prerequisites ... 00:40:10 Who truly needs GLP-1 versus lifestyle change alone ... 00:43:09 Muscle, bone, and shifting focus to building health ... 00:51:30 Nutrient intake, fiber, and supplement personalization ... 00:55:11 Digestive enzymes and optimizing digestion ... 01:03:10 Food noise, satiety, and psychological freedom ... 01:07:29 Ongoing assessment: tracking weight, fat, muscle ... 01:15:19 Weaning off GLP-1 and the importance of professional support ... 01:18:32 Our Amazing Sponsors: by Oxford Healthspan: Primeadine supports autophagy — your cells’ natural renewal and cleanup process — using food-derived spermidine, no fasting required. If you want to support resilience from the inside out, head to and use code BIONAT15 at checkout (one-time purchases only). by BiOptimizers: Better sleep isn’t about willpower — it’s about absorption. Magnesium Breakthrough uses seven real forms of magnesium that help you rest deeper and recover faster. Get up to 35% off at with code BIONAT. Bundle: pairs a probiotic proven to arrive 100% alive with digestive bitters that support digestion and curb cravings, so you actually feel the difference fast. Save 20% on your first Gut Essentials Bundle at with code NAT20 — 100% money-back guarantee. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39515105

#400: Why Chasing Muscle for Longevity Might Backfire: The Real Keys to Aging Well With Joel Greene. 01/02/2026

#400: Why Chasing Muscle for Longevity Might Backfire: The Real Keys to Aging Well With Joel Greene. Today, I’m excited to bring back the always thought-provoking , author of “The Immunity Code” and “The Way,” for a fresh conversation on why true longevity is about so much more than how much muscle you have or the latest diet trend you’re following. Joel Greene opens up about the hard lessons he’s learned from decades of self-experimentation and reveals why chasing that ideal gym physique might actually backfire as you age. Episode Timestamps: Welcome & episode introduction ... 00:00:00 The evolving nature of health and homeostasis ... 00:08:29 Beware rigid diet tribes—find nutritional flexibility ... 00:21:41 Biomarkers people miss: fasting insulin and acyl carnitines ... 00:23:11 Chronic ketosis, ATP, and metabolic slowdowns ... 00:25:16 Myth-busting muscle and the limits of bodybuilding for aging ... 00:27:17 Functional movement, flexibility, and big toe strength ... 00:34:29 Simple foundation: daily jumps or hops ... 00:47:41 Sensible protocols for muscle gain after 50 ... 01:00:07 Balance in diet as the true key to insulin sensitivity ... 01:08:06 Rules of thumb: meal timing for insulin ... 01:15:56 Stillness, faith, and feeding your spirit ... 01:21:56 Most abused supplement: Antioxidants ... 01:27:54 Body fat percentage as top longevity marker ... 01:29:12 Our Amazing Sponsors: - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it’s easy to try for yourself. Visit and use code NAT10 to start the free trial. from Young Goose - Brings the message back loud and clear. With NAD+ APEX™️ to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, “Hey, start making that collagen again!” It’s longevity science, not cosmetic hype. Visit —use code NAT10 to get started, or 5NAT if you’re an existing customer. are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. Get 35% off a one-month subscription at *Special deal through January 2026. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39495085

#399: Longevity Rewired: Hormones, Sunlight & The Weight Loss LIE | Reversing Aging in 2025 With Nat Niddam 12/26/2025

#399: Longevity Rewired: Hormones, Sunlight & The Weight Loss LIE | Reversing Aging in 2025 With Nat Niddam Today, I’m joined by a lineup of trailblazers in the science of longevity: , , , , , and . Together we dig into some of the most persistent myths and cutting-edge research shaping how we age—including why “eat less, move more” misses the mark, what really causes skin cancers, breast cancer screening risks, and the often-overlooked ripple effects of perimenopause. Links to full episodes: Episode Timestamps: Welcome & podcast overview ... 00:00:00 Longevity habits handout & sponsor plug ... 00:00:48 Clean protein choices & contamination risks ... 00:01:25 Calorie focus vs. hormones in weight loss ... 00:02:42 Why calories in/calories out fails ... 00:03:27 Cellular inflammation & gut microbiome in weight ... 00:04:43 Healthy, flexible metabolism over fast metabolism ... 00:07:51 Sun exposure, genetics & skin cancer ... 00:08:02 Sunscreen myths & ingredient safety ... 00:11:47 Perimenopause symptoms beyond hot flashes ... 00:12:27 Hormone replenishment: lifestyle + medical strategies ... 00:15:35 Breaking menopause myths & self-education ... 00:19:05 Blood factors & parabiosis in aging ... 00:21:37 Plasma exchange — practical and scientific updates ... 00:26:01 Western medicine vs. chronic disease reality ... 00:28:07 Breast cancer screening & over-treatment concerns ... 00:33:16 Hormone therapy after menopause—timing & benefits ... 00:37:07 Our Amazing Sponsors: protein powder is third-party tested for more than 200 contaminants, and Puori was the only brand that earned the Clean Label Project Transparency Certificate. That level of disclosure is rare. And refreshing. If you want protein that supports your goals — without the guesswork — go to and use code NAT for 32% off your first subscription or 20% off anything on the site. - Now in NEW Glass Jars - This isn’t regular honey. Manukora’s bees collect nectar from the Manuka tea tree, which packs 3x more antioxidants and prebiotics than normal honey. Plus it naturally contains MGO, that rare antibacterial compound. Head to to save up to 31% plus get $25 worth of free gifts with the Starter Kit. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39429540

#398: The Dopamine Biohack | Brain Chemistry, Motivation & Testosterone Secrets Revealed With Lucas Aoun 12/23/2025

#398: The Dopamine Biohack | Brain Chemistry, Motivation & Testosterone Secrets Revealed With Lucas Aoun Today, I’m joined by , from Australia, supplement formulator, and self-described human guinea pig. Lucas and I dive into his personal journey from working behind the counter at his father’s pharmacy, to experimenting with early nootropic formulas, and ultimately becoming a sought-after educator in the world of biohacking. Episode Timestamps: Podcast introduction and guest welcome ... 00:00:00 Lucas Aoun’s journey into biohacking ... 00:04:13 Innovative supplement formulation and teacrine ... 00:10:00 Dopamine’s role in motivation and productivity ... 00:32:09 Bioindividual supplement responses and AI in health ... 00:17:00 Alcohol alternatives and social nootropics ... 00:39:52 Optimizing exercise timing and performance ... 00:48:49 Testosterone, thyroid, and men’s health fundamentals ... 00:53:01 Diet diversity: carnivore, vegan, and healthy fats ... 00:59:19 Catwaba Pure: origins, benefits, and uses ... 01:13:12 Our Amazing Sponsors: - an advanced cognitive enhancement formula that combines fast-acting neuropeptides, cholinergic support, and mitochondrial-boosting compounds to sharpen mental clarity, memory, and long-term brain performance. Visit and use code NAT at checkout for 20% off. protein powder is third-party tested for more than 200 contaminants, and Puori was the only brand that earned the Clean Label Project Transparency Certificate. That level of disclosure is rare. And refreshing. If you want protein that supports your goals — without the guesswork — go to and use code NAT for 32% off your first subscription or 20% off anything on the site. : Urolithin A supports muscle strength and cellular energy. It’s about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you’d get from a glass of pomegranate juice. Visit and use code nat20 for 20% off your purchase. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39387320

#397: STRESS: The Silent Accelerator of Aging (10 Free Hacks Rewiring Your Longevity) | Calm Amid Chaos With Nat Niddam 12/19/2025

#397: STRESS: The Silent Accelerator of Aging (10 Free Hacks Rewiring Your Longevity) | Calm Amid Chaos With Nat Niddam Today, it’s just me, and we’re doing things a little differently on the Longevity Podcast. With the intensity of the holiday season winding down, I wanted to take a step back from the usual deep-dives and high-tech hacks to focus on something fundamental—free, practical strategies to help you manage stress. Chronic stress is sneaky in how it accelerates aging, impacts your telomeres, and undoes even the most powerful interventions, but thankfully, there are simple ways we can start to turn things around. Episode Timestamps: Welcome and episode introduction ... 00:00:00 Immune support with bioregulators ... 00:00:40 Why focus on free stress management tools ... 00:01:54 How chronic stress accelerates aging ... 00:04:32 Stress undermining longevity interventions ... 00:05:13 The importance of nervous system balance ... 00:06:50 Recognizing hidden stress and using HRV ... 00:07:45 When to seek further medical help ... 00:09:46 Recap: chronic stress shortens your healthspan ... 00:10:21 10 free strategies to manage stress ... 00:12:25 Connection and volunteering ... 00:13:15 Break the doom scrolling habit ... 00:17:37 Benefits of time in nature ... 00:20:02 Exercise for resilience ... 00:22:41 Breath work and vagus nerve support ... 00:25:33 Practicing gratitude daily ... 00:31:33 The power of sleep ... 00:34:30 Taking time for yourself ... 00:35:19 Our Amazing Sponsors: by Profound Helath - The Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. The Pineal Bioregulator supports your natural melatonin/circadian rhythm—key when schedules and daylight change—so you get the kind of sleep that underpins immune resilience. Head to and use code NAT15 for 15% off your first order. : C15 is 3x more effective than omega-3 and totally vegan. You can get an additional 15% off their 90-day subscription Starter Kit by going to and using code NATNIDDAM at checkout. Nat's Links: /episode/index/show/biohackingsuperhumanperformance/id/39387315

LONGEVITY with Nathalie Niddam

TOPICS