Ep. 6: Dr. Joshua Durham; Family Doc Gets Red-pilled by Seed Oils—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Release Date: 09/08/2022
Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people. It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers. Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells. “The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in...
info_outline
Ep. 20: Are Seed Oils a Problem?—with Jacob Hands (Ep. 19 Excerpt)
Tucker Goodrich: Debugging Life
info_outline
Ep. 19: Jacob M. Hands—What's Wrong With Fish Oil (Chocolate too!?!)?
Tucker Goodrich: Debugging Life
Introduction What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that’s bad for your health? Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish oils. We discuss omega-3 and health, fish oils and oxidation, the science of seed oils and health, and, as a bonus, the problem with chocolates. This is definitely a bit of a geek fest, so let me know if you have any questions. Guest info Jacob...
info_outline
Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance. Scientists can easily induce insulin resistance in humans. How do they do it, and what might it tell us about what has caused our epidemic of diabetes? Guest info Matt Quinn Biography: TL;DR Here's what I...
info_outline
Ep. 17: Making Better Meat—Autumn Smith and John Etchart
Tucker Goodrich: Debugging Life
Introduction We’re honored to be joined today by Autumn Smith of Paleovalley and John Etchart of Wild Pastures. These related companies (John is Autumn’s brother-in-law) work to deliver healthy, regeneratively-farmed foods to their customers. “At Paleovalley, our mission is to help people reclaim vibrant health. We provide products that prioritize nutrient density in an industry that prioritizes everything else. We believe that every dietary choice and every added ingredient is a powerful opportunity to love and care for oneself.” Wild Pastures: “Turning The Page To A Healthier You...
info_outline
Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have. This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes. “The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed] (1) Asthma (2) ...
info_outline
Ep. 15: A.J. Hulbert on the Omega Balance—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life. “In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created. An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other...
info_outline
Ep. 14: How a Common Asian Genetic Mutation Leads to Chronic Disease, and What to Do—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand. This was a difficult video for me to edit, as both Matt and Brian share their experiences with the topic we are discussing in their own families. I thought this was excellent, and hope many others can learn...
info_outline
Ep. 13: Chef Andrew Gruel: Learning to Cook Again—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction Brian and I are honored to be joined by the illustrious Chef Andrew Gruel. He tells us the story of how he got into cooking, how he had to learn to cook again after discovering that his academic chef training left out natural fats, and the impact using proper fats has had on his health, the health of his staff, and his customers in his latest restaurant venture. We also have an extensive and very interesting discussion on fish, fish farming, and the health benefits of eating fish. Guest info Web: (It throws a security error…) X: Substack: “The Food Porn Master”! ...
info_outline
Ep. 12: Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn
Tucker Goodrich: Debugging Life
Introduction We’re trying something a bit different today. Dr. Brian Kerley and I have found a victim, Matt Quinn. Matt’s a smart guy but he’s not as immersed in these topics as we are, and so he’s going to play our straight man, the every-day guy who can hopefully come to easily-digested conclusions about the papers we discuss. In our inaugural episode we discuss “Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 PUFA”. Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis,...
info_outlineDr. Durham is a Family Physician in Boise, Idaho; and is Tucker's doctor.
We discuss how his practice has changed since he figured out how to solve his own chronic health problems, how this has changed his practice, some successes, and more.
Joshua Durham, DO
• https://www.saintalphonsus.org/provider/joshua-durham
Blog comment:
Dr. Durham: “If you need a family Dr. here in Boise hit me up. I went from 235lbs to keto to carnivore and then finally came across your info. Now at 195 I feel comfortable knowing what I can and can't have and why I was so sick. Felt great on carnivore but can't live that way forever. Thank you for your work.”
• http://yelling-stop.blogspot.com/2021/04/experts-do-as-we-say-not-as-we-do.html?showComment=1620609617154#c416429453974276542
“Doctor of Osteopathy vs. Medical Doctor- What are the Differences?”
• https://hecec.human.cornell.edu/2016/02/12/doctor-of-osteopathy-vs-medical-doctor-what-are-the-differences/
Dr. Eric Westman
• https://ericwestmanmd.com/
New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek
• https://amzn.to/3qd9fzy (this link benefits the podcast!)
Dr. Durham: “Good fat/bad fat” I wrote a post about this: “Good Keto vs. Bad Keto”
• http://yelling-stop.blogspot.com/2021/09/good-keto-vs-bad-keto.html
Dr. Durham: “Then I saw your interview with Paul Saladino…”
• “How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease, with Tucker Goodrich” https://carnivoremd.com/how-seed-oils-destroy-your-mitochondria-and-lead-to-chronic-disease-with-tucker-goodrich/
“…and then I watched Brad Marshall…”
• Brad’s blog is here: https://fireinabottle.net/
Drs. Kerley and Durham compare “elevator pitches” to patients.
Dr. Durham: “I needed 4 pills based on the guidelines, and I was 38 years old.”
Tucker: “Lean-Mass Hyper Responder”:
Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), 460. https://doi.org/10.3390/metabo12050460
Dr. Durham: 40:02 “American College of Cardiology article…”
Astrup, A., Magkos, F., Bier, D. M., Brenna, J. T., de Oliveira Otto, M. C., Hill, J. O., King, J. C., Mente, A., Ordovas, J. M., Volek, J. S., Yusuf, S., & Krauss, R. M. (2020). Saturated Fats and Health: A Reassessment and Proposal for Food-based Recommendations: JACC State-of -the-Art Review. Journal of the American College of Cardiology, 76(7), 844–857. https://doi.org/10.1016/j.jacc.2020.05.077
See Episode 5, in which we interview Tom Brenna, one of the co-authors of that article: https://www.youtube.com/watch?v=rrQ8q_ctGUQ
Tucker: “The AGEs, same thing—Chris Masterjohn did a great post years ago looking into it:
Masterjohn, C. (2011, October 7). Where Do Most AGEs Come From? O Glycation, How Thy Name Hast Deceived Me! | [Blog]. Chris Masterjohn, PhD. https://chrismasterjohnphd.com/blog/2011/10/07/where-do-most-ages-come-from-o
Tucker: “Polyunsaturated fats are about 10x as effective in producing advanced glycation end products [than glucose]…”
Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996). The Advanced Glycation End Product, N-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions. Journal of Biological Chemistry, 271(17), 9982–9986. https://doi.org/10.1074/jbc.271.17.9982
Tucker: Lp(a):
• Hazard ratio 16.8: Tsimikas, S., Brilakis, E. S., Miller, E. R., McConnell, J. P., Lennon, R. J., Kornman, K. S., Witztum, J. L., & Berger, P. B. (2005). Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease. New England Journal of Medicine, 353(1), 46–57. https://doi.org/10.1056/NEJMoa043175
• Hazard ratio 1 in Africa: Paré, G., Çaku, A., McQueen, M., Anand, S. S., Enas, E., Clarke, R., Boffa, M. B., Koschinsky, M., Wang, X., Yusuf, S., & null, null. (2019). Lipoprotein(a) Levels and the Risk of Myocardial Infarction Among 7 Ethnic Groups. Circulation, 139(12), 1472–1482. https://doi.org/10.1161/CIRCULATIONAHA.118.034311
• 2 sure-fire ways to raise Lp(a):
1. Statins: Yeang, C., Hung, M.-Y., Byun, Y.-S., Clopton, P., Yang, X., Witztum, J. L., & Tsimikas, S. (2016). Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). Journal of Clinical Lipidology, 10(3), 594–603. https://doi.org/10.1016/j.jacl.2016.01.005
2. Healthy diet: Navab Mohamad, Reddy Srinivasa T., Van Lenten Brian J., & Fogelman Alan M. (2004). Apparent Paradox of Low-Fat “Healthy” Diets Increasing Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a). Arteriosclerosis, Thrombosis, and Vascular Biology, 24(3), 392–393. https://doi.org/10.1161/01.ATV.0000118014.49565.fc
• Pork and LDL: Stewart, J. W., Kaplan, M. L., & Beitz, D. C. (2001). Pork with a high content of polyunsaturated fatty acids lowers LDL cholesterol in women. The American Journal of Clinical Nutrition, 74(2), 179–187. https://doi.org/10.1093/ajcn/74.2.179
Treating Lp(a)/OxLDL with antibodies: https://www.oxitopepharma.com/approach
Dr. Kerley: Robb Wolf interview: https://www.youtube.com/watch?v=Lku8kJdHOqY
Wooden breast in chickens:
Soglia, F., Mudalal, S., Babini, E., Di Nunzio, M., Mazzoni, M., Sirri, F., Cavani, C., & Petracci, M. (2016). Histology, composition, and quality traits of chicken Pectoralis major muscle affected by wooden breast abnormality. Poultry Science, 95(3), 651–659. https://doi.org/10.3382/ps/pev353
“Dr. Mark Cucuzzella – A Doctor’s Perspective On Treating Diabetes” https://robbwolf.com/2016/07/26/episode-329-dr-mark-cucuzzella-a-doctors-perspective-on-treating-diabetes/