Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Release Date: 05/02/2024
Ep. 22: John Speakman—What Causes Obesity?
Tucker Goodrich: Debugging Life
Introduction I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert. Our discussion was prompted by his recent paper, “Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure”, which casts a new light onto the world pandemic of obesity. In addition to discussing a few of the papers that...
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Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people. It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers. Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells. “The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in...
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Ep. 20: Are Seed Oils a Problem?—with Jacob Hands (Ep. 19 Excerpt)
Tucker Goodrich: Debugging Life
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Ep. 19: Jacob M. Hands—What's Wrong With Fish Oil (Chocolate too!?!)?
Tucker Goodrich: Debugging Life
Introduction What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that’s bad for your health? Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish oils. We discuss omega-3 and health, fish oils and oxidation, the science of seed oils and health, and, as a bonus, the problem with chocolates. This is definitely a bit of a geek fest, so let me know if you have any questions. Guest info Jacob...
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Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance. Scientists can easily induce insulin resistance in humans. How do they do it, and what might it tell us about what has caused our epidemic of diabetes? Guest info Matt Quinn Biography: TL;DR Here's what I...
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Ep. 17: Making Better Meat—Autumn Smith and John Etchart
Tucker Goodrich: Debugging Life
Introduction We’re honored to be joined today by Autumn Smith of Paleovalley and John Etchart of Wild Pastures. These related companies (John is Autumn’s brother-in-law) work to deliver healthy, regeneratively-farmed foods to their customers. “At Paleovalley, our mission is to help people reclaim vibrant health. We provide products that prioritize nutrient density in an industry that prioritizes everything else. We believe that every dietary choice and every added ingredient is a powerful opportunity to love and care for oneself.” Wild Pastures: “Turning The Page To A Healthier You...
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Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have. This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes. “The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed] (1) Asthma (2) ...
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Ep. 15: A.J. Hulbert on the Omega Balance—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life. “In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created. An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other...
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Ep. 14: How a Common Asian Genetic Mutation Leads to Chronic Disease, and What to Do—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand. This was a difficult video for me to edit, as both Matt and Brian share their experiences with the topic we are discussing in their own families. I thought this was excellent, and hope many others can learn...
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Ep. 13: Chef Andrew Gruel: Learning to Cook Again—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction Brian and I are honored to be joined by the illustrious Chef Andrew Gruel. He tells us the story of how he got into cooking, how he had to learn to cook again after discovering that his academic chef training left out natural fats, and the impact using proper fats has had on his health, the health of his staff, and his customers in his latest restaurant venture. We also have an extensive and very interesting discussion on fish, fish farming, and the health benefits of eating fish. Guest info Web: (It throws a security error…) X: Substack: “The Food Porn Master”! ...
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Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people.
It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers.
Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells.
“The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma” (Hu et al., 2002)
Guest info
Matt Quinn
Biography:
TL;DR Here's what I am working on:
I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here
I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this
I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here
In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here
I have failed at so so so many things - read about them here
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Co-host
Dr. Brian Kerley
https://www.seedoilrebellion.com/
https://twitter.com/SeedOilDsrspctr
Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
Tucker Goodrich
Substack: https://tuckergoodrich.substack.com/
Twitter: https://twitter.com/TuckerGoodrich
Youtube: https://www.youtube.com/tuckergoodrich0
Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: https://sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/
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Show Notes
Hu, W., Feng, Z., Eveleigh, J., Iyer, G., Pan, J., Amin, S., Chung, F.-L., & Tang, M. (2002). The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma. Carcinogenesis, 23(11), 1781–1789.
https://doi.org/10.1093/carcin/23.11.1781
Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection
Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
Goodrich, T. D. (2021, July 8). Interview: Thomas Seyfried on Glioblastoma, Metabolic Cancer Breakthroughs, with David Gornoski on A Neighbor’s Choice [Blog]. Yelling Stop.
https://yelling-stop.blogspot.com/2021/07/podcast-interview-thomas-seyfried-with.html
Soussi, T. (2000). The P53 Tumor Suppressor Gene: From Molecular Biology to Clinical Investigation. Annals of the New York Academy of Sciences, 910, 121–137; discussion 137-139.
https://doi.org/10.1111/j.1749-6632.2000.tb06705.x
Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006). P53 Regulates Mitochondrial Respiration. Science, 312(5780), 1650–1653.
https://doi.org/10.1126/science.1126863
The American Oil Chemists’ Society. (2004, June). Wilhelm Normann (1870-1939). INFORM Magazine.
Goodrich, T. D. (2016, January 14). Thyroid and Low-Carb: What Do Thyroid Hormones Do? [Blog]. Yelling Stop.
https://open.substack.com/pub/tuckergoodrich/p/thyroid-and-low-carb-what-do-thyroid