#406: Peptide OVERLOAD: When Biohacking Backfires (How NOT to Crash Your Mitochondria) With Anthony Castore
LONGEVITY with Nathalie Niddam
Release Date: 01/23/2026
#406: Peptide OVERLOAD: When Biohacking Backfires (How NOT to Crash Your Mitochondria) With Anthony Castore
LONGEVITY with Nathalie Niddam
Today, I’m joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators. Use code NAT10 for 10% off products at Episode Timestamps: Welcome and episode introduction ... 00:00:00 Anthony Castore’s path from strength coaching to cellular medicine ... 00:05:55 Connecting strength training with cellular...
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#405: Heart Attacks Aren’t What You Think | The Plaque LIE That Changes Everything (Cardiology 2.0) With Dr. Sanjay Bhojraj
LONGEVITY with Nathalie Niddam
Today, I’m joined by the deeply thoughtful and refreshingly honest , a self-described “curious cardiologist” who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it? Episode Timestamps: Welcome to Longevity & episode setup … 00:00:00 Dr. Bhojraj’s shift from ER cardiology to prevention … 00:06:30 Why most heart attacks aren’t caused by big blockages … 00:09:15 Stress, nervous system load & heart attack risk … 00:13:10 CIMT explained: what it measures...
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#404: The Dirty Truth About Your Home’s WATER (And Why Most Filters Including Reverse Osmosis Don’t Cut It) With Charles Bohdy and Victor Sagalovsky
LONGEVITY with Nathalie Niddam
Today, I’m joined by , a true innovator in , and Victor Sagalovsky, a passionate advocate for bringing the science of water quality into our daily lives. Together, we take a deep dive into the unseen world of the water running through our homes—exploring not just its purity, but its hidden potential to support our biology in ways most of us have never considered. - Use code NAT100 Episode Timestamps: Intro to Longevity Podcast and today’s water focus ... 00:00:00 Water system’s health benefits and testing ... 00:01:33 Why water quality is overlooked yet critical ... 00:07:20...
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#403: What’s REALLY In Your Food? | Dark Secrets of Ultra-Pasteurized Milk, Natural Flavors & Microplastics EXPOSED With Ben Katz
LONGEVITY with Nathalie Niddam
Today, I’m joined by Ben Katz—better known online as —an academic analytical chemist from UC Irvine whose mission is to uncover what’s really in our everyday foods, drinks, and products. Ben reverse engineers everything from Taco Bell meat to Doritos, and sometimes even entire industries, using cutting-edge mass spectrometry. His curiosity and expertise have made him a go-to source for those wanting to know what’s hiding behind vague ingredient labels and “natural flavors.” Episode Timestamps: Welcome and podcast introduction ... 00:00:00 What is mass spectrometry? ......
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#402: Gut Reset: The SECRET Signals for Longevity Revealed | How to Heal Your Microbiome, Banish Bloating, and Build Resilience With Nat Niddam
LONGEVITY with Nathalie Niddam
Today, I’m kicking off the new year with a back-to-basics deep dive into one of the most pivotal yet overlooked foundations of longevity: gut health. Over the past episodes, we’ve explored everything from gene therapy to advanced tech, but it all comes back to the habits and systems we rely on every single day—and the gut is right at the center of that equation. Episode Timestamps: Gut health as the cornerstone of longevity ... 00:00:00 Why disease and wellness begin in the gut ... 00:03:46 Symptoms and signs of gut imbalance ... 00:08:53 Normalizing digestive discomfort ......
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#401: Personalization Is EVERYTHING: The New Science of Weight Health, GLP-1s, and Building Lasting Longevity With Ashley Koff
LONGEVITY with Nathalie Niddam
Today, I’m joined by the insightful , renowned registered dietitian and fierce advocate for personalized, realistic nutrition that actually works in the real world. In this episode, Ashley Koff opens up about her personal and professional journey—from her early days in big brand marketing (think sugared cereals and infobesity) to her pivotal “aha” moments that led her to champion true weight health, not just weight loss. Episode Timestamps: Welcome and introduction to the Longevity Podcast ... 00:00:00 Personal experiences shaping nutrition philosophy ... 00:05:59 Influence of...
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#400: Why Chasing Muscle for Longevity Might Backfire: The Real Keys to Aging Well With Joel Greene.
LONGEVITY with Nathalie Niddam
Today, I’m excited to bring back the always thought-provoking , author of “The Immunity Code” and “The Way,” for a fresh conversation on why true longevity is about so much more than how much muscle you have or the latest diet trend you’re following. Joel Greene opens up about the hard lessons he’s learned from decades of self-experimentation and reveals why chasing that ideal gym physique might actually backfire as you age. Episode Timestamps: Welcome & episode introduction ... 00:00:00 The evolving nature of health and homeostasis ... 00:08:29 Beware rigid diet...
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#399: Longevity Rewired: Hormones, Sunlight & The Weight Loss LIE | Reversing Aging in 2025 With Nat Niddam
LONGEVITY with Nathalie Niddam
Today, I’m joined by a lineup of trailblazers in the science of longevity: , , , , , and . Together we dig into some of the most persistent myths and cutting-edge research shaping how we age—including why “eat less, move more” misses the mark, what really causes skin cancers, breast cancer screening risks, and the often-overlooked ripple effects of perimenopause. Links to full episodes: Episode Timestamps: Welcome & podcast overview ... 00:00:00 Longevity habits handout & sponsor plug ... 00:00:48 Clean protein choices & contamination risks ......
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#398: The Dopamine Biohack | Brain Chemistry, Motivation & Testosterone Secrets Revealed With Lucas Aoun
LONGEVITY with Nathalie Niddam
Today, I’m joined by , from Australia, supplement formulator, and self-described human guinea pig. Lucas and I dive into his personal journey from working behind the counter at his father’s pharmacy, to experimenting with early nootropic formulas, and ultimately becoming a sought-after educator in the world of biohacking. Episode Timestamps: Podcast introduction and guest welcome ... 00:00:00 Lucas Aoun’s journey into biohacking ... 00:04:13 Innovative supplement formulation and teacrine ... 00:10:00 Dopamine’s role in motivation and productivity ... 00:32:09 Bioindividual...
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#397: STRESS: The Silent Accelerator of Aging (10 Free Hacks Rewiring Your Longevity) | Calm Amid Chaos With Nat Niddam
LONGEVITY with Nathalie Niddam
Today, it’s just me, and we’re doing things a little differently on the Longevity Podcast. With the intensity of the holiday season winding down, I wanted to take a step back from the usual deep-dives and high-tech hacks to focus on something fundamental—free, practical strategies to help you manage stress. Chronic stress is sneaky in how it accelerates aging, impacts your telomeres, and undoes even the most powerful interventions, but thankfully, there are simple ways we can start to turn things around. Episode Timestamps: Welcome and episode introduction ... 00:00:00 Immune...
info_outlineToday, I’m joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.
Use code NAT10 for 10% off products at https://alchemiqlabs.com/
Episode Timestamps:
Welcome and episode introduction ... 00:00:00
Anthony Castore’s path from strength coaching to cellular medicine ... 00:05:55
Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27
Explaining and balancing AMPK and mTOR for performance ... 00:13:03
Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18
Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04
Assessing recovery capacity and individualizing protocols ... 00:26:02
Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57
Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00
Differentiating bodybuilder vs. longevity approaches ... 00:34:44
Integrating peptides and support molecules into routines ... 00:40:44
Ketone esters and mitochondrial peptide interventions ... 00:41:20
Cautions on stacking and combining interventions ... 00:54:04
Lessons learned from overdoing interventions ... 01:05:02
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