#412: From Anti-Aging to Age Reversal: The Exosome & Copper Peptide Breakthrough For Younger Skin With Debbi Barber and Dr. Jordan Plews
LONGEVITY with Nathalie Niddam
Release Date: 02/13/2026
LONGEVITY with Nathalie Niddam
Today, I’m joined by the thoughtful , a naturopathic doctor blending ancient wisdom from Chinese medicine with cutting-edge regenerative therapies. In this episode, Dr. Lee gets real about why people can feel deeply unwell long before anything shows up on standard labs—and how subtle issues like limbic system stress, toxins, and chronic inflammation quietly undermine our vitality. Episode Timestamps: Welcome and episode overview ... 00:00:00 Prolotherapy, Chinese medicine, and complex healing cases ... 00:05:16 Common misconceptions in chronic illness treatment ... 00:13:15 Why...
info_outlineLONGEVITY with Nathalie Niddam
Today, I’ve got a conversation that goes deep into the cutting edge of regenerative skin health with two exceptional guests: Debbi Barber, founder and muse of , and Dr. Jordan Plews, a biochemical engineer and stem cell researcher. We discuss the science and practical realities of exosomes, stem cells, and copper peptides—breaking down not just what makes skin look younger, but what truly keeps it biologically healthier and more resilient as we age. Visit and use code Nat20 Episode Timestamps: Welcome and podcast purpose ... 00:00:00 Shift from beauty to science and health...
info_outlineLONGEVITY with Nathalie Niddam
Today, I’m joined by —a clinician, author of , and a powerful force in rethinking everything we thought we knew about heart disease. Dr. Hussey’s own journey began with type 1 diabetes as a child, and despite living a healthy, active lifestyle, he experienced a widowmaker heart attack at just 34 years old. In our conversation, he opens up about what it was like to face this crisis with “perfect” lab numbers, how it challenged his entire perspective, and ultimately led him to a radical new understanding of heart health and longevity. Episode Timestamps: Podcast introduction and...
info_outlineLONGEVITY with Nathalie Niddam
Today, I’m joined by the wonderful Dr. Shivani Gupta, a true force in bridging ancient Ayurvedic wisdom with cutting-edge modern research on inflammation and healthy aging. She recently authored The Inflammation Code. Dr. Shivani opens up about her deeply personal motivation—from witnessing her grandfather’s preventable health decline to spending years in both traditional and scientific studies, ultimately earning a PhD focused on turmeric and chronic inflammation. For Dr. Shivani’s Turmeric and sleep gummies visit and use code NAT15 for 15% off. Episode Timestamps: Welcome...
info_outlineLONGEVITY with Nathalie Niddam
Today, I’m joined by the inspiring —a trailblazer in longevity medicine who once spent decades as an interventional cardiologist, only to challenge everything he knew after his own health hit a wall. Dr. Gladden opens up about the moment he refused to accept “normal for your age” as a diagnosis, launching himself into the world of functional and age-management medicine to reclaim his vitality and help others do the same. Episode Timestamps: Welcome and episode introduction ... 00:00:00 Health crisis and discovering personal optimization ... 00:07:05 From “sick care” to...
info_outlineLONGEVITY with Nathalie Niddam
Today, I’m sitting down with , a good friend and one of my favorite collaborators when it comes to cutting-edge insights in personalized health and longevity. In this episode, I put myself under the microscope as we walk through my own metabolomics testing after a period of heavy travel, stress, and—yes—a break from my usual supplement routine. If you’ve ever wondered whether skipping your foundational health habits “just for a little while” really matters, you’re about to find out. If you are a clinician and would like to offer the Aristotle test to your patients please use...
info_outlineLONGEVITY with Nathalie Niddam
Today, I’m joined by the remarkable , a pioneer in redefining the longevity conversation by making muscle health—not weight—the centerpiece of aging well. With a background in geriatrics and nutritional sciences, she illuminates why the quality of your muscle tissue is a far more powerful predictor of health than any number on the scale. Her perspective challenges the notion of a “healthy sedentary person” and reveals the major role of intramuscular fat in metabolic dysfunction. Check out her book . Episode Timestamps: Introduction, podcast focus, and welcoming Dr....
info_outlineLONGEVITY with Nathalie Niddam
Today, I’m joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators. Use code NAT10 for 10% off products at Episode Timestamps: Welcome and episode introduction ... 00:00:00 Anthony Castore’s path from strength coaching to cellular medicine ... 00:05:55 Connecting strength training with cellular...
info_outlineLONGEVITY with Nathalie Niddam
Today, I’m joined by the deeply thoughtful and refreshingly honest , a self-described “curious cardiologist” who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it? Episode Timestamps: Welcome to Longevity & episode setup … 00:00:00 Dr. Bhojraj’s shift from ER cardiology to prevention … 00:06:30 Why most heart attacks aren’t caused by big blockages … 00:09:15 Stress, nervous system load & heart attack risk … 00:13:10 CIMT explained: what it measures...
info_outlineLONGEVITY with Nathalie Niddam
Today, I’m joined by , a true innovator in , and Victor Sagalovsky, a passionate advocate for bringing the science of water quality into our daily lives. Together, we take a deep dive into the unseen world of the water running through our homes—exploring not just its purity, but its hidden potential to support our biology in ways most of us have never considered. - Use code NAT100 Episode Timestamps: Intro to Longevity Podcast and today’s water focus ... 00:00:00 Water system’s health benefits and testing ... 00:01:33 Why water quality is overlooked yet critical ... 00:07:20...
info_outlineToday, I’ve got a conversation that goes deep into the cutting edge of regenerative skin health with two exceptional guests: Debbi Barber, founder and muse of Vitali Skincare, and Dr. Jordan Plews, a biochemical engineer and stem cell researcher. We discuss the science and practical realities of exosomes, stem cells, and copper peptides—breaking down not just what makes skin look younger, but what truly keeps it biologically healthier and more resilient as we age.
Visit https://www.vitaliskincare.com/?ref=Nat20 and use code Nat20
Episode Timestamps:
Welcome and podcast purpose ... 00:00:00
Shift from beauty to science and health ... 00:09:23
GHK-Cu’s role in longevity and skin repair ... 00:10:15
Dr. Plews on regenerative medicine and stem cells ... 00:11:14
From peptides to exosomes: product evolution ... 00:13:35
Stem cell exhaustion and need for exosome signaling ... 00:14:07
Copper peptides vs. exosomes: complementary actions ... 00:18:00
Why source and age of exosomes matter ... 00:25:20
Quality, safety, and labeling in exosome products ... 00:35:01
How exosomes and peptides benefit skin deeper layers ... 00:44:35
Visible results: barrier, redness, scars, texture ... 00:58:05
What to expect: younger vs. older skin ... 01:00:01
Proof and stories: customer transformations ... 01:01:59
More isn’t better: exosome dosing myth ... 01:07:03
Supporting ingredients: vitamin C, glutathione, SOD2 ... 01:11:31
Skin as a window into systemic aging ... 01:19:08
The future: personalized, organ-targeted exosome therapies ... 01:24:02
Our Amazing Sponsors:
Nature’s Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order.
Manukora Honey - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to MANUKORA.com/NAT to save up to 31% plus $25 in free gifts with the Starter Kit.
PW1 by Puori — A clean, high-quality whey protein that’s third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site.
Nat's Links: