#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum
LONGEVITY with Nathalie Niddam
Release Date: 03/06/2026
#420: Spermidine UNLOCKED: Reverse Aging, Boost Immunity & Thrive After 40 With Leslie Kenny
LONGEVITY with Nathalie Niddam
Today, I'm joined by the inspiring , Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable. Leslie has a generous offer for you, when you visit and use code BIONAT20 at...
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#419: A Mind-Blowing Mitochondria Episode— Mito Transplant, Rare Diseases & Biomarkers With Dr. Natalie Yivgi-Ohana
LONGEVITY with Nathalie Niddam
Today, I’m joined by the extraordinary , a pioneering scientist whose passion for mitochondria unlocks new frontiers in longevity medicine. Our conversation truly blew my mind—Dr. Yivgi-Ohana brings decades of expertise to demystify these tiny, ancient powerhouses that fuel every cell in our bodies, impact our hormones, drive immunity, and, as it turns out, play a central role in how we age. Episode Timestamps: Welcome to the Longevity Podcast and today's focus on mitochondria ... 00:00:00 Maternal inheritance and critical functions of mitochondria ... 00:05:56 Mitochondria as...
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#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum
LONGEVITY with Nathalie Niddam
Today, I’m joined by the insightful Courtney Van Bussum, a biomedical engineer and entrepreneur who has become a rising force in longevity science. Courtney shares how growing up in a family of healthcare innovators shaped her journey, and how she pivoted from startup life to tackling age-related challenges—especially when COVID brought her back to her roots and reignited her passion for cellular health. If you want to try Endotelio 1-MNA and save 10% and code NAT10 will be entered for you at checkout. Episode Timestamps: Welcome and introduction to Longevity Podcast ......
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#417: Depression and Weight Gain In Kids & Adults | A Long Term Post-COVID Problem & How To Reverse It With Dr. Cynthia Keller
LONGEVITY with Nathalie Niddam
Today, I’m joined by the innovative , a pediatrician whose passion for integrative and functional medicine has reshaped how we understand post-COVID health challenges. Dr. Keller opens up about her journey from conventional medicine to designing unique solutions for children and families, revealing how her care, presence, and determination to “solve the unsolvable” led to breakthroughs in treating mood changes, weight gain, and energy loss after COVID. Special Offer: If you go to and use code NatRocks at checkout, you’ll get a whopping 50% off of the Tryptophan Re-Genesis™...
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#416: The Cardiovascular Crisis No One Talks About: Women, Midlife & Nitric Oxide Explained With Cathy Eason
LONGEVITY with Nathalie Niddam
Today, I’m joined by the remarkable , whose work in the and vascular health space is changing the conversation around resilience and heart health for midlife women. Cathy dives into why cardiovascular disease is still the number one threat to women globally, and how the drop in estrogen during menopause impacts nitric oxide production—an overlooked factor that quietly influences everything from energy to cognition. Visit and use code NAT20 for 20% off. Episode Timestamps: Podcast welcome and cardiovascular focus ... 00:00:00 Introducing Cathy Eason, nitric oxide updates ......
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#415: Bioregulator Questions Answered: Follow Up To Dr. Bill Lawrence Episode With Nat Niddam
LONGEVITY with Nathalie Niddam
Today, I’m joined by Erin Ryan, my producer and long-time collaborator, for a special Q&A episode powered entirely by your questions. After our bioregulator deep dive with Dr. Bill Lawrence, the response was overwhelming—so many of you reached out with insightful queries about bioregulators, peptides, and the nuances between natural and synthetic options. Erin and I decided to tackle the most common themes, unpacking everything from organ versus system signaling to how bioregulators actually survive digestion. Nat’s favorite Bioregulators: and use code NAT15 for 15%...
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#414: The Untold Truth About Heart Health: (Women, Genetics & the JOY of Longevity) | Dr. Regina Druz Reveals All
LONGEVITY with Nathalie Niddam
Today, I’m joined by the trailblazing , a cardiologist who reimagined heart health after years in elite academic medicine. In this episode, opens up about her journey from the traditional halls of Cornell and New York Presbyterian to creating truly personalized, preventive, and holistic programs for her patients—even when it meant leaving behind the medical mainstream. Episode Timestamps: Podcast intro and Dr. Druz’s background ... 00:00:00 The value of female perspectives in cardiology ... 00:04:11 Moving from traditional to integrative cardiology ... 00:13:17 Upsides of...
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#413: Mold, Toxins, and the Cell Danger Response: How to Reclaim Energy and Resilience With Dr. Clement Lee, NMD
LONGEVITY with Nathalie Niddam
Today, I’m joined by the thoughtful , a naturopathic doctor blending ancient wisdom from Chinese medicine with cutting-edge regenerative therapies. In this episode, Dr. Lee gets real about why people can feel deeply unwell long before anything shows up on standard labs—and how subtle issues like limbic system stress, toxins, and chronic inflammation quietly undermine our vitality. Episode Timestamps: Welcome and episode overview ... 00:00:00 Prolotherapy, Chinese medicine, and complex healing cases ... 00:05:16 Common misconceptions in chronic illness treatment ... 00:13:15 Why...
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#412: From Anti-Aging to Age Reversal: The Exosome & Copper Peptide Breakthrough For Younger Skin With Debbi Barber and Dr. Jordan Plews
LONGEVITY with Nathalie Niddam
Today, I’ve got a conversation that goes deep into the cutting edge of regenerative skin health with two exceptional guests: Debbi Barber, founder and muse of , and Dr. Jordan Plews, a biochemical engineer and stem cell researcher. We discuss the science and practical realities of exosomes, stem cells, and copper peptides—breaking down not just what makes skin look younger, but what truly keeps it biologically healthier and more resilient as we age. Visit and use code Nat20 Episode Timestamps: Welcome and podcast purpose ... 00:00:00 Shift from beauty to science and health...
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#411: Rethinking Heart Health: Surrender, Sunlight, and Structured Water With Dr. Stephen Hussey
LONGEVITY with Nathalie Niddam
Today, I’m joined by —a clinician, author of , and a powerful force in rethinking everything we thought we knew about heart disease. Dr. Hussey’s own journey began with type 1 diabetes as a child, and despite living a healthy, active lifestyle, he experienced a widowmaker heart attack at just 34 years old. In our conversation, he opens up about what it was like to face this crisis with “perfect” lab numbers, how it challenged his entire perspective, and ultimately led him to a radical new understanding of heart health and longevity. Episode Timestamps: Podcast introduction and...
info_outlineToday, I’m joined by the insightful Courtney Van Bussum, a biomedical engineer and entrepreneur who has become a rising force in longevity science. Courtney shares how growing up in a family of healthcare innovators shaped her journey, and how she pivoted from startup life to tackling age-related challenges—especially when COVID brought her back to her roots and reignited her passion for cellular health.
If you want to try Endotelio 1-MNA and save 10% click here and code NAT10 will be entered for you at checkout.
Episode Timestamps:
Welcome and introduction to Longevity Podcast ... 00:00:00
Challenging beliefs about aging and cellular health ... 00:12:00
Deep dive into NAD+ biochemistry and cellular function ... 00:13:08
NAD+/NADH balance: Why both matter ... 00:15:24
Why NAD+ declines: Not just aging, but increased degradation ...00:18:26
The role of CD38 and NMNT enzymes in NAD metabolism ... 00:20:14
Controversy and confusion: NAD+ precursors (NR, NMN) and IVs ... 00:22:28
Methylation’s hidden importance in NAD supplementation ... 00:30:55
Supplementing 1-MNA: Understanding dosages and applications ... 00:50:54
Assessing NAD+ status: Biomarkers and limitations of testing ... 00:53:01
Lifestyle ROI: Sleep, exercise, and circadian rhythm for NAD preservation ... 00:57:14
Ketones: Beyond performance, supporting cellular energy and longevity ... 01:06:03
Future of NAD science: Anticipating new insights and risks ... 01:11:45
Confidence and humility: Advice for navigating the longevity field ... 01:18:52
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