Ep. 11: Paul Saladino, MD: The Intellectual Journey of a Physician—with Dr. Joshua Durham
Tucker Goodrich: Debugging Life
Release Date: 01/22/2024
Ep. 26: How To Lie With Science (Nick Jikomes Livestream)
Tucker Goodrich: Debugging Life
Introduction Nick asked me to do a YouTube livestream to go over some research he had been doing. He drilled down on a reference in a high-profile cardiology guideline article and discovered that the authors had inverted the research finding in the referenced paper to claim the inverse of what it actually showed. We discussed this, and then I gave some more context about the matter and one of the authors. Guest info “Nick Jikomes is a neuroscientist, plant chemistry researcher, data scientist, and podcast host. He received a PhD in Neuroscience from Harvard University and a Bachelor of...
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Ep. 25: Is Mikhail Shchepinov "Breaking The Chains of Aging"?
Tucker Goodrich: Debugging Life
Introduction It's well-known that lipid peroxidation is involved in aging and longevity. But what can we do about it? Dr. Shchepinov has been researching using deuterium to 'shore up' the PUFAs like those in seed oils to prevent them become toxic metabolites. He's had some interesting successes, and we discuss at length his new book: “Breaking the Chains of Aging”. Amazon link: Book website Research: Biography: Mikhail Shchepinov trained in Moscow (PhD, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 1994), then moved to Oxford to work on DNA microarray technology,...
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Ep. 24: Does Deuterium Cause Chronic Disease? With Prof. John Speakman
Tucker Goodrich: Debugging Life
Introduction I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert. Our discussion was prompted by his recent paper, “Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure”, which casts a new light onto the world pandemic of obesity. In addition to discussing a few of the papers that...
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Ep. 23: "Ep 23 Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy"—with Raphael Sirtoli and Dave Feldman
Tucker Goodrich: Debugging Life
Introduction So apparently there is some demand for discussion/debate on the topic of seed oils and health. Dave Feldman (Ep. 9) had considered doing this at his recent conference, but couldn’t fit in the time. He’s since regained interest in the idea, and reached out to Andreas Eenfeldt and Ted Naiman, who have expressed skepticism. They replied: “We decline as we feel this debate is a distraction. The reason is that we see no good scientific evidence for replacing any source of added pure fat with another. It's not the right question.” Since there’s so much interest, and clearly...
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Ep. 22: John Speakman—What Causes Obesity?
Tucker Goodrich: Debugging Life
Introduction I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert. Our discussion was prompted by his recent paper, “Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure”, which casts a new light onto the world pandemic of obesity. In addition to discussing a few of the papers that...
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Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people. It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers. Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells. “The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in...
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Ep. 20: Are Seed Oils a Problem?—with Jacob Hands (Ep. 19 Excerpt)
Tucker Goodrich: Debugging Life
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Ep. 19: Jacob M. Hands—What's Wrong With Fish Oil (Chocolate too!?!)?
Tucker Goodrich: Debugging Life
Introduction What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that’s bad for your health? Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish oils. We discuss omega-3 and health, fish oils and oxidation, the science of seed oils and health, and, as a bonus, the problem with chocolates. This is definitely a bit of a geek fest, so let me know if you have any questions. Guest info Jacob...
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Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance. Scientists can easily induce insulin resistance in humans. How do they do it, and what might it tell us about what has caused our epidemic of diabetes? Guest info Matt Quinn Biography: TL;DR Here's what I...
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Ep. 17: Making Better Meat—Autumn Smith and John Etchart
Tucker Goodrich: Debugging Life
Introduction We’re honored to be joined today by Autumn Smith of Paleovalley and John Etchart of Wild Pastures. These related companies (John is Autumn’s brother-in-law) work to deliver healthy, regeneratively-farmed foods to their customers. “At Paleovalley, our mission is to help people reclaim vibrant health. We provide products that prioritize nutrient density in an industry that prioritizes everything else. We believe that every dietary choice and every added ingredient is a powerful opportunity to love and care for oneself.” Wild Pastures: “Turning The Page To A Healthier You...
info_outlineWe interview Paul Saladino MD about his intellectual journey from being a raw vegan with rotting teeth as a physician’s assistant, through becoming the “Carnivore MD”, to where he is today. We discuss the training a physician receives in medical school about nutrition, and how he filled that gap with his own experience and research. And how it impacted his health and his ideas about being a physician.
Josh Durham, my personal physician, joins me as co-host today to recount his personal health journey as well and how it changed his practice. (He recently quit his job at a large hospital to go independent!)
Paul Saladino, MD:
https://www.paulsaladinomd.co/
Dr. Saladino’s "The Carnivore Code" book:
Biography of Paul Saladino:
I’m a double board certified MD, host of the Fundamental Health podcast, and author of The Carnivore Code and The Carnivore Code Cookbook.
I believe in questioning our assumptions about health and nutrition, which makes me controversial in modern medicine. I'm much more interested in optimal health than in dogmatic adherence to a mainstream narrative.
I graduated from medical school at the University of Arizona in Tucson, and completed my residency at the University of Washington in Seattle. After residency, I attained a board certification as a Physician Nutrition Specialist.
Throughout my medical training, I came to one very saddening conclusion: our Western medical system isn’t helping people lead richer lives.
Western medicine fails to treat the root cause of chronic illness, and doctors are only taught to treat symptoms with medications, rather than trying to understand the roots of illness.
I firmly believe that nutritional choices lie at the ROOT of so many chronic illnesses that western medicine deems irreversible.
And I also believe that most chronic illnesses are preventable AND reversible.
https://www.paulsaladinomd.co/about
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Co-host Joshua Durham, DO:
Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
Tucker Goodrich
Substack: https://tuckergoodrich.substack.com/
Twitter: https://twitter.com/TuckerGoodrich
Youtube: https://www.youtube.com/tuckergoodrich0
Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825
Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y
Podcast: https://sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/
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Show Notes
Jordan Petersen on Joe Rogan discussing carnivore diet:
https://www.youtube.com/watch?v=HLF29w6YqXs
Farley Mowat "People of the Deer" book:
https://amzn.to/3Uc42bh
Amgen: "8 Things to Know About Lipoprotein(a)"
https://www.amgen.com/stories/2023/02/8-things-to-know-about-lipoproteina
"AMGEN ANNOUNCES POSITIVE TOPLINE PHASE 2 DATA FOR INVESTIGATIONAL OLPASIRAN IN ADULTS WITH ELEVATED LIPOPROTEIN(a)":
https://www.amgen.com/newsroom/press-releases/2022/05/amgen-announces-positive-topline-phase-2-data-for-investigational-olpasiran-in-adults-with-elevated-lipoproteina
"Seed oils are BS" t-shirt: https://www.bunkerbranding.com/collections/paul-saladino-md-shirts/products/seed-oils-are-bs?variant=42776441782403
If you have any questions about sources for things discussed please ask in the comments.