Ep. 15: A.J. Hulbert on the Omega Balance—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Release Date: 02/22/2024
Ep. 23: "Ep 23 Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy"—with Raphael Sirtoli and Dave Feldman
Tucker Goodrich: Debugging Life
Introduction So apparently there is some demand for discussion/debate on the topic of seed oils and health. Dave Feldman (Ep. 9) had considered doing this at his recent conference, but couldn’t fit in the time. He’s since regained interest in the idea, and reached out to Andreas Eenfeldt and Ted Naiman, who have expressed skepticism. They replied: “We decline as we feel this debate is a distraction. The reason is that we see no good scientific evidence for replacing any source of added pure fat with another. It's not the right question.” Since there’s so much interest, and clearly...
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Ep. 22: John Speakman—What Causes Obesity?
Tucker Goodrich: Debugging Life
Introduction I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert. Our discussion was prompted by his recent paper, “Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure”, which casts a new light onto the world pandemic of obesity. In addition to discussing a few of the papers that...
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Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people. It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers. Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells. “The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in...
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Ep. 20: Are Seed Oils a Problem?—with Jacob Hands (Ep. 19 Excerpt)
Tucker Goodrich: Debugging Life
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Ep. 19: Jacob M. Hands—What's Wrong With Fish Oil (Chocolate too!?!)?
Tucker Goodrich: Debugging Life
Introduction What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that’s bad for your health? Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish oils. We discuss omega-3 and health, fish oils and oxidation, the science of seed oils and health, and, as a bonus, the problem with chocolates. This is definitely a bit of a geek fest, so let me know if you have any questions. Guest info Jacob...
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Ep. 18: What Causes Insulin Resistance?—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance. Scientists can easily induce insulin resistance in humans. How do they do it, and what might it tell us about what has caused our epidemic of diabetes? Guest info Matt Quinn Biography: TL;DR Here's what I...
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Ep. 17: Making Better Meat—Autumn Smith and John Etchart
Tucker Goodrich: Debugging Life
Introduction We’re honored to be joined today by Autumn Smith of Paleovalley and John Etchart of Wild Pastures. These related companies (John is Autumn’s brother-in-law) work to deliver healthy, regeneratively-farmed foods to their customers. “At Paleovalley, our mission is to help people reclaim vibrant health. We provide products that prioritize nutrient density in an industry that prioritizes everything else. We believe that every dietary choice and every added ingredient is a powerful opportunity to love and care for oneself.” Wild Pastures: “Turning The Page To A Healthier You...
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Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have. This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes. “The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed] (1) Asthma (2) ...
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Ep. 15: A.J. Hulbert on the Omega Balance—with Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life. “In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created. An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other...
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Ep. 14: How a Common Asian Genetic Mutation Leads to Chronic Disease, and What to Do—with Matt Quinn and Dr. Brian Kerley
Tucker Goodrich: Debugging Life
Introduction We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand. This was a difficult video for me to edit, as both Matt and Brian share their experiences with the topic we are discussing in their own families. I thought this was excellent, and hope many others can learn...
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We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life.
“In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created.
An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other inflammatory diseases. Omega balance is also important for normal brain function, and an imbalance in these fatty acids is associated with depression, mood disorders, and neurodegenerative diseases.
Hulbert provides extensive information on the omega balance of different foods and discusses fascinating details about human evolution, dietary changes throughout history, the effect of diet on human development and physiological processes, and more. He investigates the paleo diet of our ancestors and describes the dramatic changes that have accompanied the increased ultra-processing of modern foods. Omega Balance is an essential guide to understanding a significant problem in our modern food chain and will make us rethink the food we eat.
https://press.jhu.edu/books/title/12823/omega-balance
Amazon link to benefit this podcast: https://amzn.to/49JHXFo
This book won a “Best Book” award from the American Book Fest in the category “Health: Diet and Exercise”.
https://www.americanbookfest.com/2023bbafullresults.html
Guest info
I was introduced to Prof. Hulbert by Prof. Tom Brenna, our guest in Ep. 5: Prof. Tom Brenna, Omega-3 and Omega-6 in Human Health.
Biography:
“Anthony John Hulbert (UNSW, AUS), PhD, DSc, is an internationally renowned researcher on metabolism, longevity, and nutrition. He is emeritus professor in Science, Medicine, and Health at the University of Wollongong, Australia.”
https://press.jhu.edu/books/title/12823/omega-balance#book__authors
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Co-host
Co-host Dr. Brian Kerley
https://www.seedoilrebellion.com/
https://twitter.com/SeedOilDsrspctr
Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
Tucker Goodrich
Substack: https://tuckergoodrich.substack.com/
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Podcast: https://sites.libsyn.com/408758
Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/
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Show Notes
In order of discussion.
Borchman, D., Stimmelmayr, R., & George, J. C. (2017). Whales, Lifespan, Phospholipids, and Cataracts. Journal of Lipid Research, 58(12), 2289–2298. https://doi.org/10.1194/jlr.M079368
Hulbert, A. J., & Else, P. L. (1999). Membranes as Possible Pacemakers of Metabolism. Journal of Theoretical Biology, 199(3), 257–274. https://doi.org/10.1006/jtbi.1999.0955
Abbott, S. K., Else, P. L., Atkins, T. A., & Hulbert, A. J. (2012). Fatty Acid Composition of Membrane Bilayers: Importance of Diet Polyunsaturated Fat Balance. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818(5), 1309–1317. https://doi.org/10.1016/j.bbamem.2012.01.011
McCollum, E. V. (1919). The Newer Knowledge of Nutrition. Macmillan Company. https://ia801302.us.archive.org/28/items/cu31924104225937/cu31924104225937.pdf
Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. https://doi.org/10.1038/s42255-023-00782-2
Allport, S. (2010, November). One Person’s Response to a High Omega-6 Diet [Magazine]. American Oil Chemists’ Society. https://www.aocs.org/stay-informed/inform-magazine/featured-articles/one-persons-response-to-a-high-omega-6-diet-november-2010?SSO=True
If you have any questions about sources for things discussed please ask in the comments.