Patrick Holford, BSc: Alzheimer’s Prevention with Evidence-Based Approaches that Target the Disease Process
Release Date: 06/05/2025
Dr. Miguel Toribio-Mateas: Navigating Nutrition Misinformation with Context, Nuance and Compassion
Nutritional Medicine Podcast
Dr Miguel is a remarkable scientist in that he gracefully bridges the worlds of research, education, clinical practice, public outreach and compassion in his work. This interview explores topics relevant to the translation of science to real world relevance in an authentic, compassionate and humanistic way. We also explore his new book ADHD Body and Mind: A Compassionate Guide to Rewilding Your Nervous System with Neuroscience, Nutrition, and Gut-Brain Health. Guest: Dr. Miguel Toribio-Mateas About our guest: Dr. Miguel Toribio-Mateas is a clinical neuroscientist,...
info_outline
Dr. Alan Gaby: Nutritional Medicine; Important Treatments that are Overlooked or Ignored
Nutritional Medicine Podcast
Who literally wrote the book on nutritional medicine? Dr Alan Gaby. In this interview, Dr Gaby talks about his pioneering work that ultimately resulted in the publication of what is arguably the most important reference text in the field: Nutritional Medicine, Third Edition 2023. In addition, he discusses explore nutritional therapies that are clinically very useful but broadly overlooked including potassium magnesium aspartate for fatigue, riboflavin for migraine prevention and identifying hidden food allergies for treating various conditions. Guest: Dr. Alan Gaby, MD About...
info_outline
Dr. Ryan Bradley: Transforming Cardiometabolic Health with Personalised Lifestyle Medicine
Nutritional Medicine Podcast
Cardiometabolic disorders are the leading cause of morbidity and mortality yet can largely be prevented with diet and lifestyle medicine. Why is there a gap between this epidemic and more effective treatment? Dr. Bradley discusses his clinical research on feasible, cost-effective, efficacious interventions and wider topics around personalised whole person care and ‘disruptive innovation’ for health promotion. Guest: Dr. Ryan Bradley, ND, MPH About our guest: Dr. Bradley is an Associate Professor in the University of California, San Diego Herbert...
info_outline
Professor Joseph Firth: Improving Mental Health Outcomes with Nutrition and Lifestyle Medicine
Nutritional Medicine Podcast
The concepts of ‘lifestyle psychiatry,’ and ‘nutritional psychiatry’ are transforming the way we think about mental health and wellbeing. Professor Joseph Firth shares his influential work in this area and its implications for changing clinical practice and health policy. We also discuss the digital environment as a newly evolving lifestyle factor that influences mental health. About our guest: Dr. Firth is Professor of Psychology & Mental Health, University of Manchester, Manchester, U.K, with a PhD (Medicine) from The University of Manchester. ...
info_outline
Dr Adrian Lopresti: Mental Health, Evidence-Based Nutraceuticals and Personalised Integrative Therapy
Nutritional Medicine Podcast
Dr Adrian Lopresti shares important clinical insights from his published research on natural products such as saffron, ashwagandha, curcumin and magnesium on anxiety, depression and insomnia. He also discusses personalised Integrative therapy, a holistic treatment model he has pioneered that places the use of natural products in the wider context of lifestyle medicine and nutritional psychiatry. About our guest: Dr Adrian Lopresti is the managing director at Clinical Research Australia, a clinical psychologist, and an adjunct senior lecturer at Murdoch University,...
info_outline
Dr. Iain P. Hargreaves: CoQ10, Mitochondrial Dysfunction, Deficiency Diseases and Clinical Considerations
Nutritional Medicine Podcast
Coenzyme Q10 has established use across both primary and secondary deficiency diseases. In this episode, Dr. Iain P. Hargreaves, PhD, an eminent scientist working on CoQ10, walks us through its history, functions, his work looking at blood brain barrier transport, clinical considerations around testing and supplementation, and where research is going in the future. About our guest: Dr. Iain P. Hargreaves, PhD is Senior Lecturer in Clinical Biochemistry / Honorary Consultant Clinical Scientist at the Neurometabolic Unit, National Hospital, Queen Square, London, UK School...
info_outline
Dr. Kirstie Lawton: Motor Neurone and Neurodegenerative Disease; New Hope with Systems-Based Nutritional Medicine
Nutritional Medicine Podcast
Neurodegenerative diseases, including Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease and Huntington's Disease, are generally considered progressive and irreversible, but a personalised, systems biology-based approach could challenge this view. A better understanding of the biology, modifiable contributors, and the use of personalised nutritional medicine is radically changing the way we think about neurodegenerative disease, and in this episode Dr. Kirstie Lawton, PhD explains why. About our guest: Dr. Kirstie Lawton, PhD is an AfN...
info_outline
Dr. Denise Furness: Nutrigenomics; Using Genetic Testing to Guide Personalised Nutrition
Nutritional Medicine Podcast
Genetic testing can help guide highly individualised diet and lifestyle medicine-based interventions and is also highly motivational. We meet Dr Denise Furness, a pioneer and thought leader on nutrigenomics and hear how she started in research and extended into clinical work and education for health professionals focusing on the role of genomics in nutritional and lifestyle medicine. Our discussion includes foundational concepts around nutrigenomics in clinical practice and her recent BIO AGE study. Guest: Dr. Denise Furness, PhD About our guest: Dr. Denise...
info_outline
Dr. Thomas Guilliams: Supplementing Dietary Nutrients; Navigating Controversy, Evidence and Clinical Use
Nutritional Medicine Podcast
Thomas G. Guilliams, PhD is an expert in a systems-biology based approach to dietary interventions, lifestyle medicine and nutritional and herbal supplements. This conversation shares his insights from extensive experience in dietary supplements that culminated in the publication of a foundational textbook, Supplementing Dietary Nutrients. We discus important themes such as how to contextualise the use and expectations of supplements alongside dietary and lifestyle changes, marketing vs. science, bioavailability, and issues around quality. Guest: Thomas G. Guilliams, PhD ...
info_outline
Dr. David Unwin: Drug-Free Remission of Cardiometabolic Disease; Diet, Behavioural Change, and Ultra-Processed Food Addiction
Nutritional Medicine Podcast
Dr David Unwin started a grass-roots approach to reversing cardiometabolic disease, in particular type-2 diabetes, in his clinical practice that has resulted in the publication of clinical evidence documenting patient outcomes and spurred a global movement that is transforming people’s lives. In this remarkable conversation he shares his story, insights from the work he is doing, and new concepts around ultra-processed food addiction. Guest: Dr. David Unwin About our guest: Dr David Unwin is an award-winning GP known for pioneering the low-carb...
info_outlineIn this episode we speak with Patrick Holford, founder and chair of the Food for the Brain scientific advisory board and author of Alzheimer's: Prevention is the Cure (2025). Highlighting why drug therapies have failed for Alzheimer's we look beyond a single-drug single-target approach to multi-component nutrition and lifestyle medicine-based approaches that not only target multiple disease processes, but have been shown to reverse, not just prevent, Alzheimer's disease in well-conducted clinical research. The discussion includes actionable biomarkers for personalised preventative approaches using nutrition.
Guest:
Patrick Holford BSc, DipION, FBANT, NTCRP
About our guest:
Patrick Holford is Founder and Chair of the Food for the Brain Foundations Scientific Advisory Board. He is a retired visiting professor, specialising in nutrition and mental health, author of over 45 books and is in the Orthomolecular Medicine Hall of Fame. In 1984 he founded the Institute for Optimum Nutrition.
He started in the field of psychology and then became a student of two of the leading pioneers in nutrition medicine and psychiatry – the late Dr Carl Pfeiffer and Dr Abram Hoffer. In 1984 he founded the Institute for Optimum Nutrition (ION), now degree-accredited, to train a new profession – the first generation of nutritional therapists and to define what it means to be optimally nourished. His mentor, twice Nobel Prize winner Dr Linus Pauling, was patron.
In 1998 Patrick left ION to focus on writing down what he’d learnt and his first book, the Optimum Nutrition Bible, was published, selling over 2 million copies and catalysing a global revolution. He’s now written over 45 books translated into over 30 languages.
One of his current focusses is on helping people with mental health issues and in 2003 he founded the Brain Bio Centre and in 2007 he founded the Food for the Brain Foundation.
In 2014, Patrick was inducted to the Orthomolecular Medicine Hall of Fame, joining his mentors Drs Linus Pauling and Abram Hoffer. He has also been awarded an honorary Diploma from ION and is also an Honorary Fellow of the British Association of Nutrition and Lifestyle Medicine. He is also a retired visiting professor at the University of Teeside.
Guest websites and links:
Selection of our guest’s publications:
- Holford P. Alzheimer's: Prevention is the Cure. Holford Press. 2025.
Additional publications:
- Smith AD, Refsum H. Homocysteine - from disease biomarker to disease prevention. J Intern Med. 2021 Oct;290(4):826-854.