#390: Muscle, Mitophagy, and Longevity: How Urolithin A Supports Healthy Aging and Athletic Performance With Brad Currier, PhD
LONGEVITY with Nathalie Niddam
Release Date: 11/25/2025
LONGEVITY with Nathalie Niddam
Today, I’m joined by , a true innovator in , and Victor Sagalovsky, a passionate advocate for bringing the science of water quality into our daily lives. Together, we take a deep dive into the unseen world of the water running through our homes—exploring not just its purity, but its hidden potential to support our biology in ways most of us have never considered. - Use code NAT100 Episode Timestamps: Intro to Longevity Podcast and today’s water focus ... 00:00:00 Water system’s health benefits and testing ... 00:01:33 Why water quality is overlooked yet critical ... 00:07:20...
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Today, I’m joined by Ben Katz—better known online as —an academic analytical chemist from UC Irvine whose mission is to uncover what’s really in our everyday foods, drinks, and products. Ben reverse engineers everything from Taco Bell meat to Doritos, and sometimes even entire industries, using cutting-edge mass spectrometry. His curiosity and expertise have made him a go-to source for those wanting to know what’s hiding behind vague ingredient labels and “natural flavors.” Episode Timestamps: Welcome and podcast introduction ... 00:00:00 What is mass spectrometry? ......
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Today, I’m kicking off the new year with a back-to-basics deep dive into one of the most pivotal yet overlooked foundations of longevity: gut health. Over the past episodes, we’ve explored everything from gene therapy to advanced tech, but it all comes back to the habits and systems we rely on every single day—and the gut is right at the center of that equation. Episode Timestamps: Gut health as the cornerstone of longevity ... 00:00:00 Why disease and wellness begin in the gut ... 00:03:46 Symptoms and signs of gut imbalance ... 00:08:53 Normalizing digestive discomfort ......
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Today, I’m joined by the insightful , renowned registered dietitian and fierce advocate for personalized, realistic nutrition that actually works in the real world. In this episode, Ashley Koff opens up about her personal and professional journey—from her early days in big brand marketing (think sugared cereals and infobesity) to her pivotal “aha” moments that led her to champion true weight health, not just weight loss. Episode Timestamps: Welcome and introduction to the Longevity Podcast ... 00:00:00 Personal experiences shaping nutrition philosophy ... 00:05:59 Influence of...
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Today, I’m excited to bring back the always thought-provoking , author of “The Immunity Code” and “The Way,” for a fresh conversation on why true longevity is about so much more than how much muscle you have or the latest diet trend you’re following. Joel Greene opens up about the hard lessons he’s learned from decades of self-experimentation and reveals why chasing that ideal gym physique might actually backfire as you age. Episode Timestamps: Welcome & episode introduction ... 00:00:00 The evolving nature of health and homeostasis ... 00:08:29 Beware rigid diet...
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Today, I’m joined by a lineup of trailblazers in the science of longevity: , , , , , and . Together we dig into some of the most persistent myths and cutting-edge research shaping how we age—including why “eat less, move more” misses the mark, what really causes skin cancers, breast cancer screening risks, and the often-overlooked ripple effects of perimenopause. Links to full episodes: Episode Timestamps: Welcome & podcast overview ... 00:00:00 Longevity habits handout & sponsor plug ... 00:00:48 Clean protein choices & contamination risks ......
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Today, I’m joined by , from Australia, supplement formulator, and self-described human guinea pig. Lucas and I dive into his personal journey from working behind the counter at his father’s pharmacy, to experimenting with early nootropic formulas, and ultimately becoming a sought-after educator in the world of biohacking. Episode Timestamps: Podcast introduction and guest welcome ... 00:00:00 Lucas Aoun’s journey into biohacking ... 00:04:13 Innovative supplement formulation and teacrine ... 00:10:00 Dopamine’s role in motivation and productivity ... 00:32:09 Bioindividual...
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Today, it’s just me, and we’re doing things a little differently on the Longevity Podcast. With the intensity of the holiday season winding down, I wanted to take a step back from the usual deep-dives and high-tech hacks to focus on something fundamental—free, practical strategies to help you manage stress. Chronic stress is sneaky in how it accelerates aging, impacts your telomeres, and undoes even the most powerful interventions, but thankfully, there are simple ways we can start to turn things around. Episode Timestamps: Welcome and episode introduction ... 00:00:00 Immune...
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Today, I’m joined by —founder of Biocybernaut and a true pioneer in the world of neurofeedback. With over four decades spent mapping how our brainwaves shape emotions, performance, and even identity, Dr. Hardt has helped reframe the conversation around unlocking human potential, making cutting-edge brain training accessible to seekers, creatives, and everyday biohackers alike. Download a FREE copy of his book “The Art of Smart Thinking” at Episode Timestamps: Intro to Longevity Podcast and host ... 00:00:00 Introduction to Dr. James Hardt and neurofeedback ... 00:00:34 Alpha...
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Today, I’m sitting down with the irrepressible , renowned biotech innovator and founder of , a groundbreaking formula for liver health. Siggi’s story is deeply personal—motivated by the loss of loved ones to liver disease, he’s made it his life’s mission to demystify liver health and help others avoid the fate that touched his own family. Visit code: NAT for 5% off Episode Timestamps: Introduction and podcast themes ... 00:00:00 Eastern vs. Western liver views ... 00:07:09 Why liver health is central to longevity ... 00:09:28 Hidden toxins: everyday exposures ......
info_outlineToday, I’m joined by Dr. Brad Currier, Manager of Clinical Trials at Timeline Nutrition and an expert in the world of muscle and aging research. Brad is on the cutting edge of mitochondrial science, and in this episode, he helps us unravel the mysteries of why some 80-year-olds are still crushing it in the gym while others struggle to get up the stairs. We dive into his fascinating research on mitophagy—our bodies’ system for recycling dysfunctional mitochondria—and what it means for muscle health, strength, and vibrant aging.
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Episode Timestamps:
Episode start … 00:00:00
What is Mitophagy? Why It Matters as We Age ... 00:04:53
Mitophagy in Athletes vs. General Population ... 00:07:15
Urolithin A and Why Most People Can’t Make It ... 00:12:12
What Mitopure Does: Mitophagy and Biogenesis ... 00:24:10
Key Study: Strength Gains in Middle-Aged Adults ... 00:26:43
Dose Guidance: 500mg vs. 1g ... 00:31:39
Anti-Inflammatory Effects and Immune Health ... 00:33:07
Benefits Beyond Muscle: Skin, Immunity, Brain ... 00:35:01
Weightlifter Study: Performance in Trained Athletes ... 00:40:34
Mitopure for Recovery and User Experiences ... 00:46:41
How to Use Mitopure: Timing, Dosage, Consistency ... 00:52:54
Protein, Creatine, and Mitopure: The Basics Stack ... 00:53:41
Recovery, Cycling, and How Soon Benefits Appear ... 00:58:44
Debunking Myths: Pomegranate, Antioxidant, Athletes Only ... 01:10:26
Mitopure vs. Generic Urolithin A: Safety Concerns ... 01:13:39
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