Natalie Wexler: ChatGPT Can Rot Your Brain
Critically Speaking
How does ChatGPT affect your ability to learn, recall, and share information? In this episode, Therese Markow and Natalie Wexler discuss the impact of generative AI (like ChatGPT) on education. They discuss the change in writing skills, how AI can undermine the learning process that comes with writing, and the incorrect information often provided by generative AI. Natalie explains how AI can function as cognitive outsourcing, which can reduce the cognitive benefits of learning and memory retention. She emphasizes the importance of explicit writing instruction in education and background...
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Ru Marshall: American Trickster - Carlos Castaneda
Critically Speaking
Ru Marshall pulls back the curtain on the man behind the myth of Carlos Castaneda, exposing the real lives, lies, and losses buried beneath his legendary books. In this episode, Therese Markow and Ru Marshall discuss the life and legacy of Carlos Castaneda, who claimed to have been trained as a shaman by Don Juan. Castaneda's books, which sold over 8 million copies, were initially believed but later dismissed as fiction. Marshall’s book, "American Trickster," explores Castaneda's origins in Peru and his life in the U.S. Castaneda, born Cesar Arana, was a charismatic storyteller who seduced...
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Patrick Wyman: Lost Worlds
Critically Speaking
In this episode, Therese Markow and Patrick Wyman discuss Patrick’s latest book, Lost Worlds: How Humans Tried, Failed, Succeeded, and Built Our World. Patrick also discusses his journey as a historian from studying the Fall of Rome to popular history. He emphasizes the importance of understanding past climactic changes and their impact on human societies, including the development of agriculture and the rise of social hierarchies. Patrick also highlights the significance of migration and the diverse burial practices that reveal aspects of ancient societies’ beliefs and social...
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Jeanne Marrazzo, MD: NIH-NIAID Lawsuit
Critically Speaking
When a globally respected infectious disease expert is abruptly sidelined by an anti‑vaccine administration, what does it reveal about the future of public health and scientific integrity? In this episode, Therese Markow and Dr. Jeanne Marrazzo discuss her termination and whistleblower lawsuit against the U.S. government. She highlighted NIAID's critical role in infectious disease research, funding $6.6 billion annually. Dr. Marrazzo criticized the new administration's anti-vaccine stance, cessation of global HIV/AIDS funding, and termination of clinical trials, which she argued...
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Dr. Chelsea Polis: Women's Reproductive Rights on the Move
Critically Speaking
In this episode, Therese Markow and Dr. Chelsea Polis discuss the evolution of reproductive rights in the U.S., highlighting the 2022 Supreme Court decision revoking the right to abortion and the historical context of contraception access. Dr. Polis also explains fertility awareness-based methods (FABMs) and their effectiveness, noting that some methods have moderate quality studies suggesting high effectiveness, while others are less reliable. She emphasizes the importance of evidence-based information, the need for stronger regulation of femtech products, and the potential privacy risks...
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Osteoporosis and You
Critically Speaking
In this episode, Therese Markow and Dr. Keith McCormick discuss what you need to know about osteoporosis and bone health. Dr. McCormick explains what causes osteoporosis, the importance of early bone density tests, and breaks down some of the lifestyle factors that affect bone health. They discuss the need for personalized treatment beyond only medication, and Dr. McCormick advocates for patient empowerment and comprehensive understanding to improve treatment outcomes. Key Takeaways: 50% of women will get osteoporosis. 20% of men will get osteoporosis. People...
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Dr. Dawn Sarno: Cyberscams and You
Critically Speaking
In this episode, Therese Markow and Dr. Dawn Sarno, a leading expert on cyber scams, discuss the prevalence and detection of phishing scams. Dawn explains that phishing often targets older adults due to their perceived lack of tech savvy and higher financial stakes, but notes that younger adults are also vulnerable, often due to impulsivity and poor online habits. She highlights the rise of AI-generated deep fakes, which make scams more convincing and harder to detect. Dawn advises slowing down and verifying suspicious communications, emphasizing the importance of cyber hygiene practices, such...
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Dr. Daniel Buchman: Do You Suffer From Chronic Pain?
Critically Speaking
In this episode, Therese Markow and Dr. Daniel Buchman discuss chronic pain, affecting over 20% of the population in the US, Canada, and Europe. Chronic pain (persisting pain lasting over three months) includes conditions like arthritis, lower back pain, fibromyalgia, and phantom limb pain, among many others. Daniel highlights the challenges in pain assessment, the role of AI in pain management, and the ethical considerations, including bias in pain reporting. He notes that chronic pain increases suicide risk, and the conversation also touches on the stigma surrounding pain and opioid use....
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Dr. David Hill: Peanut and Food Allergies in Children
Critically Speaking
In this episode, Therese Markow and Dr. David Hill discuss the rise of peanut allergies in children. David explains that anaphylaxis, a severe allergic reaction, is common in children, often triggered by food. He emphasizes the importance of early allergen introduction to prevent allergies. The LEAP study from 2015 showed that introducing peanuts before six months reduces the risk of peanut allergy. They also discuss other common allergies and the fact that many children outgrow milk and egg allergies by age four. Key Takeaways: The major allergens are milk, egg, soy,...
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Dr. Fred Miller: The Autoimmune Disease Epidemic
Critically Speaking
In this episode, Therese Markow and Dr. Fred Miller discuss the autoimmune disease epidemic, highlighting the economic burden and the rise of diseases like juvenile diabetes, lupus, and multiple sclerosis. Dr. Miller explains that autoimmune diseases occur when the immune system attacks the body, affecting various organs. He notes that there are at least 150 types of autoimmune diseases, with prevalence rates varying from 0.1% to 5% of the population - the exact number is unknown due to the need for better registries to track these diseases. Dr. Miller also discusses the role of genetics and...
info_outlineIn this episode, Therese Markow and Dr. John Kisiel discuss early cancer detection using liquid biopsies. Dr. Kisiel explains that liquid biopsies detect cancer signals in blood and urine, including tumor cells, fragments, proteins, and DNA. He highlights the FDA's approval of a blood test for colon cancer and the development of multi-cancer early detection tests. Dr. Kisiel notes that false positive and false negative rates vary by test. He emphasizes the potential of liquid biopsies to complement, not replace, standard screening methods and the need for further validation and clinical trials.
Key Takeaways:
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Liquid biopsies have been used in the oncology community to test if cancer is still present, may need additional or more aggressive treatment, or if the cancer has come back.
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Each test will have its own false positive and false negative rate, partially based on where manufacturers set the thresholds for that positive/negative result.
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Peripheral blood-based tests for colon cancer do not detect polyps, and it's the finding and removing of polyps that actually offers the greatest preventive benefit, so that somebody never gets cancer in the first place.
"Another word of cautious optimism, I think that I, personally, and many other people active in the space really view these as an addition to standard of care cancer screening and not a replacement." — Dr. John Kisiel
Connect with Dr. John Kisiel:
Professional Bio: https://www.mayo.edu/research/faculty/kisiel-john-b-m-d/bio-00092659
Connect with Therese:
Website: www.criticallyspeaking.net
Bluesky: @CriticallySpeaking.bsky.social
Instagram: @criticallyspeakingpodcast
Email: theresemarkow@criticallyspeaking.net
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