Women’s Biohacking and Longevity Secrets | Dr. Kathleen O’Neil
The Girlfriend Doctor w/ Dr. Anna Cabeca
Release Date: 01/20/2026
Women’s Biohacking and Longevity Secrets | Dr. Kathleen O’Neil
The Girlfriend Doctor w/ Dr. Anna Cabeca
What if the future of women’s longevity wasn’t about fighting aging—but teaching the body how to adapt, regenerate, and thrive? In this deeply insightful episode of The Girlfriend Doctor Show, Dr. Anna Cabeca sits down with renowned longevity and regenerative medicine expert Dr. Kathleen O’Neil to unpack the cutting-edge science—and timeless fundamentals—behind women’s biohacking, immune resilience, and healthy aging. Dr. O’Neil shares her extraordinary journey from pathology and the morgue to elite performance medicine, explaining how understanding why people die transformed...
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HRT in the Blue Zones and How to Solve the Adrenal Crisis | Dr. Sangeeta Pati
The Girlfriend Doctor w/ Dr. Anna Cabeca
Midlife has a way of getting your attention, especially when your body starts changing in ways no one really prepared you for, and menopause is often right at the center of it. In this conversation, we talk honestly about what’s really happening during this season and what women can do to feel more like themselves again. You’ll hear how small, intentional shifts can lead to more energy, clarity, and resilience over time. This episode is about moving from just getting through midlife to actually feeling good in it. I sat down with Dr. Sangeeta Pati, MD, FACOG, ABOIM, a...
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The Girlfriend Doctor Podcast Best of 2025
The Girlfriend Doctor w/ Dr. Anna Cabeca
As we look back on 2025, one thing became clear. The episodes that resonated most were not about quick fixes. They were about helping women finally understand their bodies. This year, you leaned into conversations that offered clarity instead of confusion, compassion instead of restriction, and real explanations for why your body responds the way it does. In this special Best of 2025 episode, we are revisiting the moments that moved you most. You will hear powerful clips on gut health, hormones, burnout, mitochondria, intimacy, alcohol, oral and eye health, and the nervous system. Again...
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How to Increase Libido After Menopause Naturally | Gabriella Espinosa
The Girlfriend Doctor w/ Dr. Anna Cabeca
So many women hit midlife and suddenly find themselves whispering about things they never thought they’d struggle with, like desire, dryness, disconnection, or feeling like a stranger in their own body. That quiet discomfort adds up, and it can take a real toll on intimacy and self-confidence. In this episode, we start talking about what’s actually going on with your hormones, your libido, and your relationships, so you can finally get clarity instead of guessing. Gabriella Espinosa, a Menopause Advocate, Women’s Health and Sexual Wellness Coach, and Host of Pleasure in the...
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How to Increase Oxytocin levels + Why You Need To | Dr. Tyna Moore
The Girlfriend Doctor w/ Dr. Anna Cabeca
Oxytocin might get all the hype as the “love hormone,” but the way it quietly shapes our mood, relationships, and everyday well-being is honestly pretty incredible once you understand it. In today’s episode, you’ll get a clear look at what this hormone is actually doing behind the scenes and why it plays such a big role in how connected, calm, and joyful we feel. We break down the real science in simple language and talk about the places where oxytocin shows up in your life without you even noticing. I’m sitting down with my good friend, Dr. Tyna Moore, one of the smartest and...
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Why You Probably Need to Drink Less | Dr. Brooke Scheller
The Girlfriend Doctor w/ Dr. Anna Cabeca
It’s wild how easily alcohol becomes part of our routine, especially in midlife, yet so many women quietly wonder why their sleep, mood, or hormones suddenly feel out of sync. In this episode, we get real about what alcohol is actually doing behind the scenes and how a few simple nutrition shifts can change the way you feel (and even what you crave). I’m sitting down with Dr. Brooke Scheller, a Doctor of Clinical Nutrition and Founder of Functional Sobriety, whose work is helping women rethink their drinking habits with compassion and curiosity. Dr. Brooke opens up about her own...
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You're Not Getting Enough Morning Sunlight | Jack Kruse
The Girlfriend Doctor w/ Dr. Anna Cabeca
The fascinating intersections of circadian biology, quantum health, and women’s wellness really come alive as I sit down with Neurosurgeon-turned-Quantum-Biologist Dr. Jack Kruse. You’ll hear how simple things, like the light you see first thing in the morning, quietly shape your hormones, energy, and even how you age. Dr. Jack’s decades of surgical and biophysical knowledge make these concepts surprisingly practical for everyday health. By the end, you may find yourself rethinking your daily routines in the best way. Together, we get into why AM sunlight can make such a big...
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How to Boost Fertility Naturally
The Girlfriend Doctor w/ Dr. Anna Cabeca
Fertility challenges are becoming all too common, and it’s not just about trying to get pregnant. It’s about the bigger picture of how our health today shapes the next generation. I sat down with my dear friend, Dr. Ann Shippy, a brilliant Functional Medicine Physician and Author of The Preconception Revolution, to talk about what’s really driving the rise in infertility and what we can do about it long before conception even happens. Dr. Ann has such a unique perspective. She started out as a chemical engineer before becoming a doctor, so she looks at the body like a system: one...
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Can Trauma Cause Physical Pain?
The Girlfriend Doctor w/ Dr. Anna Cabeca
You know that feeling when your body’s tired but your heart’s carrying the real weight? Yeah… that’s not just stress. It’s your body holding onto stories it never got to finish, the unprocessed stuff we call trauma. In this powerful and personal conversation, Dr. Shiroko Sokitch and I get into how emotional wounds can quietly shape your physical health, and how real healing starts when you finally listen to what your body’s been trying to say. Dr. Shiroko spent years in emergency medicine before following her intuition into acupuncture and Traditional Chinese Medicine,...
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The Truth About Osteoporosis and Osteopenia
The Girlfriend Doctor w/ Dr. Anna Cabeca
Strong bones do more than prevent fractures; they help you stay active, confident, and energized no matter your age. I caught up with Kevin Ellis, aka the Bone Coach, a Forbes-featured integrative health coach who’s helped thousands of people worldwide improve their bone health through his Stronger Bones Solution. We talk about what your bone density scores really mean, the difference between bone quality and bone density, and practical steps you can take today to strengthen your bones. Kevin also shares simple nutrition tips, supplements like vitamin D3, K2, and collagen, plus safe...
info_outlineWhat if the future of women’s longevity wasn’t about fighting aging—but teaching the body how to adapt, regenerate, and thrive?
In this deeply insightful episode of The Girlfriend Doctor Show, Dr. Anna Cabeca sits down with renowned longevity and regenerative medicine expert Dr. Kathleen O’Neil to unpack the cutting-edge science—and timeless fundamentals—behind women’s biohacking, immune resilience, and healthy aging.
Dr. O’Neil shares her extraordinary journey from pathology and the morgue to elite performance medicine, explaining how understanding why people die transformed how she helps patients live longer, stronger lives. Together, they explore immune modulation, peptides, GLP-1s, light and dark therapy, bone regeneration, adrenal health, energy medicine, and why balance—not extremes—is the true secret to longevity.
From menopause and bone loss to hyperbaric oxygen therapy, peptides like oxytocin and thymosin, and the power of adaptability, this episode is a masterclass in personalized, ethical, regenerative medicine for women at every stage of life.
If you’re curious about biohacking beyond the hype—and want grounded, science-backed strategies that actually work—this conversation is for you.
Key Timestamps
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00:01:00 – Welcome & introduction to longevity and regenerative medicine
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04:05 – Dr. O’Neill’s time in the morgue and what it taught her about immunity, aging, and silent disease
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08:15 – The immune system explained: friend vs. foe, gut training, adaptability, and immune modulation
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12:18 – Light, dark, melatonin, oxytocin & why darkness is essential for regeneration
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13:19 – Feasting, fasting, and the paradoxes that build resilience and adaptability
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16:04 – GLP-1s, peptides, and why dosage variability matters for long-term results
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21:14 – Energy medicine, biochargers, frequency, vibration & photobiomodulation
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24:10 – Adrenal burnout, cortisol dysregulation, and immune collapse
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28:17 – Bone loss, ovarian aging clocks, and why prevention must start earlier
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30:04 – Bone health, muscle, oxytocin & rebuilding resilience after menopause
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36:17 – Regenerative medicine, stem cells, and ethical innovation in longevity care
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40:41 – Inside a cutting-edge regenerative medicine clinic
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41:02 – Hyperbaric oxygen therapy, lymphatic drainage & advanced recovery tools
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45:18 – Personalized medicine, foundations first, adaptability & final takeaways
Memorable Quotes
“Longevity is really gerotherapeutics—preventing aging by teaching the body how to regenerate.” – Dr. Kathleen O’Neil
“You can’t hack your life without doing the fundamentals.” – Dr. Kathleen O’Neil
“Balance—light and dark, stress and recovery—is what creates adaptability.” – Dr. Kathleen O’Neil
“The immune system is a living medication inside us.” – Dr. Kathleen O’Neil
“Everything I do today is serving the version of myself I’ll be in the future.” – Dr. Anna Cabeca
Connect With Guest
Dr. Kathleen O’Neil, MD
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Website: treatwellness.boston
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Instagram: @treatwellness_
About Dr. O’Neil:
Dr. Kathleen O’Neil earned her M.D. from Boston University School of Medicine (Magna Cum Laude) and trained at Massachusetts General Hospital and Brigham and Women’s Hospital. She is a global expert in regenerative and longevity medicine, peptide therapy, GLP-1s, and exosomes, working with elite athletes and professional teams. She is a founding board member of the International Peptide Society and the American Academy of Stem Cell Physicians and previously served as Medical Director of Tom Brady’s TB12 Wellness Center.
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