Sunday Science 2025_12_14
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Speaker-Organized Summary: Key Points, Decisions, and Next Steps Announcer Lucas Welcome to Sunday Science, where recent scientific articles and their translation into modern lives are discussed. The host for today's episode is Dr. Brent W. Lartz, M.D. Dr. Brent Laartz Summary of Key Points and Decisions The discussion focuses on a gene and gene product called Clotho, which was discovered in 1997 and is named after the Greek god of fate and destiny. Knockout mice with Clotho upregulation showed a 15-30% longer lifespan and improved cardiovascular, renal, and brain health, as well as lower...
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Week 4: The Go UnPro Podcast: A Doctor's 52 Week Journey to an Unprocessed Life
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Summary of Key Points, Decisions, and Next Steps by Speaker Dr. Brent Laartz Key Points and Decisions: Focusing on longevity and healthspan, not just cosmetic appearance Importance of polyphenols, calorie restriction, and certain medications (acarbose, canaglifosin) for longevity Emphasis on strength, grip strength, and quick movements to maintain activity into older age Strategies for navigating the holidays, including bringing own food, doing active activities with family, and tracking progress Next Steps: Continuing low-carb, no-sugar diet with focus on whole foods, vegetables, and...
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Week 3 A Doctor's 52 Week Journey to an Unprocessed Life
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Speaker-Organized Summary: Key Points, Decisions, and Next Steps Dr. Brent Lartz Key Points and Decisions: Acknowledged the difficulty of staying motivated during the holidays, but emphasized the importance of maintaining a healthy lifestyle. Discussed the concept of "holiday heart" and the negative impacts of overconsumption of unhealthy foods and alcohol during the holidays. Decided to implement pre-holiday and post-holiday work to minimize the damage to his metabolic health, such as having a vegan diet a few days before and after the holiday. Outlined his diet plan for the week,...
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Week 2 A Doctor's 52 Week Journey to an Unprocessed Life
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Key Points & Decisions: Continuing the "Go Unpro" journey to an unprocessed life, building on progress from Week 1 Focusing on the 4 pillars of longevity: diet, exercise, sleep, and social connection Instituting a low-sugar, high-fiber, mostly plant-based diet Avoiding processed foods, plastic containers, and seed oils Implementing time-restricted feeding/intermittent fasting Tracking habits and progress using apps for accountability Next Steps: Eliminate fast foods, limit packaged foods, and avoid soda this week Drink 32oz of water twice daily Eat berries daily, trying a new...
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Sunday Science by Go_UnPro Episode 1: 2025_11_02
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In this first episode of Sunday Science, we explore a few articles showing the carcinogenic potential of a strain of E coli (pks+ or colibactin-producing) that produces a DNA mutational toxin. Evidence from the discussed articles shows that this bacteria could be responsible for a high percentage of early onset (under age 50) colorectal cancer (CRC). CRC at this age is increasing and now encompasses 10% of all CRC, which percentage is growing by 2% per year. Up to 68% of these cancers have evidence of the hallmark mutations and presence of the pks+ E coli above. Diets...
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Introduction to Go Un-Pro
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Follow along with me as I transform my life, improve my health, defeat my weight challenges, and live a longer, healthier life. All while still having a blast traveling through this crazy world! This podcast is the introduction to a 52-week gradual step-by-step transformation of my diet, exercise, sleep, and life-purpose to a more mindful, whole-food, mostly vegan, movement-oriented lifestyle which will enable me to live well into my tenth decade in a healthy way. I am buying in wholeheartedly to the idea of having a centenarian olympics. I don't want to live forever,...
info_outlineIn this first episode of Sunday Science, we explore a few articles showing the carcinogenic potential of a strain of E coli (pks+ or colibactin-producing) that produces a DNA mutational toxin. Evidence from the discussed articles shows that this bacteria could be responsible for a high percentage of early onset (under age 50) colorectal cancer (CRC). CRC at this age is increasing and now encompasses 10% of all CRC, which percentage is growing by 2% per year. Up to 68% of these cancers have evidence of the hallmark mutations and presence of the pks+ E coli above. Diets high in fiber decrease and diets low in fiber increase the presence of this bacteria. As we elucidate the particular mutations associated with this and other carcinogens, we can detect these mutations within the DNA of each cancer patient. The data shows evidence of this bacteria being present in those with CRC under age 50, and it is more prevalent in countries that have a higher incidence of CRC under age 50, and likely has been present since an early age, such as the first 10 years of life.
A simple arithmetic problem of subracting 40 years from 2015 when these early-onset CRC began their increase, yields the year 1975 which is when we began to incorporate processed foods and refined sugar and high-fructose corn syrup into our diet. This and the data of onset at age 10 and before, begs us to consider what we are doing to our children and the possibility that there are a whole 40 years of children that are increasing their processed food intake. How many early-onset CRC patients will there be 40 years from now? MIcrobiome and genetic mutational research into other cancers such as oropharyngeal, bladder, and anal carcinoma could soon provide these answers.
References
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Insights into the role of the intestinal microbiota in colon cancer. Sofia Oke and Alberto Martin. Ther Adv Gastroenterol 2017, Vol. 10(5) 417 –428
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Microbiome and colorectal cancer: Unraveling host-microbiota interactions in colitis-associated colorectal cancer development. lMingsong Kang, Alberto Martin. Seminars in Immunology. Volume 32, August 2017, Pages 3-13
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Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells. Antoaneta Belcheva1 . Cell. Volume 158, Issue 2p288-299July 17, 2014
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Oliero M, Hajjar R, Cuisiniere T, Fragoso G, Calvé A and Santos MM (2023) Inulin impacts tumorigenesis promotion by colibactinproducing Escherichia coli in ApcMin/+ mice. Front. Microbiol. 14:1067505.
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Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer. Alberto Martin. Nature Microbiology 10: 855-870.
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