Sunday Science 2025_12_14
Go Un-Pro
Speaker-Organized Summary: Key Points, Decisions, and Next Steps Announcer Lucas Welcome to Sunday Science, where recent scientific articles and their translation into modern lives are discussed. The host for today's episode is Dr. Brent W. Lartz, M.D. Dr. Brent Laartz Summary of Key Points and Decisions The discussion focuses on a gene and gene product called Clotho, which was discovered in 1997 and is named after the Greek god of fate and destiny. Knockout mice with Clotho upregulation showed a 15-30% longer lifespan and improved cardiovascular, renal, and brain health, as well as lower...
info_outline
Week 4: The Go UnPro Podcast: A Doctor's 52 Week Journey to an Unprocessed Life
Go Un-Pro
Summary of Key Points, Decisions, and Next Steps by Speaker Dr. Brent Laartz Key Points and Decisions: Focusing on longevity and healthspan, not just cosmetic appearance Importance of polyphenols, calorie restriction, and certain medications (acarbose, canaglifosin) for longevity Emphasis on strength, grip strength, and quick movements to maintain activity into older age Strategies for navigating the holidays, including bringing own food, doing active activities with family, and tracking progress Next Steps: Continuing low-carb, no-sugar diet with focus on whole foods, vegetables, and...
info_outline
Week 3 A Doctor's 52 Week Journey to an Unprocessed Life
Go Un-Pro
Speaker-Organized Summary: Key Points, Decisions, and Next Steps Dr. Brent Lartz Key Points and Decisions: Acknowledged the difficulty of staying motivated during the holidays, but emphasized the importance of maintaining a healthy lifestyle. Discussed the concept of "holiday heart" and the negative impacts of overconsumption of unhealthy foods and alcohol during the holidays. Decided to implement pre-holiday and post-holiday work to minimize the damage to his metabolic health, such as having a vegan diet a few days before and after the holiday. Outlined his diet plan for the week,...
info_outline
Week 2 A Doctor's 52 Week Journey to an Unprocessed Life
Go Un-Pro
Key Points & Decisions: Continuing the "Go Unpro" journey to an unprocessed life, building on progress from Week 1 Focusing on the 4 pillars of longevity: diet, exercise, sleep, and social connection Instituting a low-sugar, high-fiber, mostly plant-based diet Avoiding processed foods, plastic containers, and seed oils Implementing time-restricted feeding/intermittent fasting Tracking habits and progress using apps for accountability Next Steps: Eliminate fast foods, limit packaged foods, and avoid soda this week Drink 32oz of water twice daily Eat berries daily, trying a new...
info_outline
Sunday Science by Go_UnPro Episode 1: 2025_11_02
Go Un-Pro
In this first episode of Sunday Science, we explore a few articles showing the carcinogenic potential of a strain of E coli (pks+ or colibactin-producing) that produces a DNA mutational toxin. Evidence from the discussed articles shows that this bacteria could be responsible for a high percentage of early onset (under age 50) colorectal cancer (CRC). CRC at this age is increasing and now encompasses 10% of all CRC, which percentage is growing by 2% per year. Up to 68% of these cancers have evidence of the hallmark mutations and presence of the pks+ E coli above. Diets...
info_outline
Introduction to Go Un-Pro
Go Un-Pro
Follow along with me as I transform my life, improve my health, defeat my weight challenges, and live a longer, healthier life. All while still having a blast traveling through this crazy world! This podcast is the introduction to a 52-week gradual step-by-step transformation of my diet, exercise, sleep, and life-purpose to a more mindful, whole-food, mostly vegan, movement-oriented lifestyle which will enable me to live well into my tenth decade in a healthy way. I am buying in wholeheartedly to the idea of having a centenarian olympics. I don't want to live forever,...
info_outlineSpeaker-Organized Summary: Key Points, Decisions, and Next Steps
Announcer Lucas
Welcome to Sunday Science, where recent scientific articles and their translation into modern lives are discussed.
The host for today's episode is Dr. Brent W. Lartz, M.D.
Dr. Brent Laartz
Summary of Key Points and Decisions
The discussion focuses on a gene and gene product called Clotho, which was discovered in 1997 and is named after the Greek god of fate and destiny.
Knockout mice with Clotho upregulation showed a 15-30% longer lifespan and improved cardiovascular, renal, and brain health, as well as lower rates of cognitive decline.
However, a recent study published in the Journals of Gerontology in 2025 found a U-shaped relationship between Clotho levels and all-cause mortality.
The study showed that both high and low levels of Clotho were associated with increased mortality, and this was linked to increased liver fibrosis.
Next Steps
Further research is needed to fully understand the relationship between Clotho levels and health outcomes.
Multiple studies on Clotho have been published in the past year, and more are expected in the next one to two years.
The speaker encourages the audience to follow the podcast on various platforms to stay updated on the latest developments in longevity and science.