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Episode 228: Dr. Thomas Seyfried - Cancer as a Metabolic Disorder

Food Junkies Podcast

Release Date: 05/08/2025

Episode 243: Bonnie Newlin, RDN - Lipedema, Food Addiction & the Power of Anti-Inflammatory Nutrition show art Episode 243: Bonnie Newlin, RDN - Lipedema, Food Addiction & the Power of Anti-Inflammatory Nutrition

Food Junkies Podcast

In this episode of the Food Junkies Podcast, Dr. Vera Tarman speaks with Bonnie Newlin, registered dietitian nutritionist, Certified LEAP Therapist, founder of Crave Nourishment, and member of the Lipedema Education Group. Bonnie specializes in the nutritional management of lipedema and chronic inflammation. Lipedema is a progressive adipose and connective tissue disorder that primarily impacts women, often misdiagnosed as obesity. Bonnie shares her own story of living with lipedema—including a 170-pound weight loss, delayed diagnosis, and eventual lipidema reduction surgery—and how food...

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Episode 242: Dr. Nicole Avena on GLP-1s show art Episode 242: Dr. Nicole Avena on GLP-1s

Food Junkies Podcast

In this episode of the Food Junkies Podcast, Dr. Vera Tarman and Clarissa Kennedy welcome back Dr. Nicole Avena — neuroscientist, researcher, and author — to discuss her team’s latest paper exploring a provocative question: Could GLP-1 receptor agonists, while reducing food cravings, also negatively impact dopamine regulation, mood, and addiction risk? Dr. Avena breaks down the science behind GLP-1 drugs, their effects on the brain’s reward pathways, and why these mechanisms might lead to unintended consequences such as anhedonia, apathy, and depressive symptoms. Together, they examine...

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Food Junkies Recovery Stories Episode 27: Christine Trimpe show art Food Junkies Recovery Stories Episode 27: Christine Trimpe

Food Junkies Podcast

Christine Trimpe is a transformative wellness leader dedicated to empowering professional Christian women to reclaim their health and vitality through her faith-based, holistic approach to weight loss. As the founder of The SugarFreed Me Method and a certified SUGAR® Licensed Practitioner, Christine helps clients achieve lifelong healing from sugar addiction and food-related struggles. Her clients experience dramatic transformations, including sustained weight loss and breakthroughs in physical, emotional, and spiritual health, with over 80% retention in her programs.   After a personal...

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Episode 241: Dr. Tro Kalayjian - TOWARD Health show art Episode 241: Dr. Tro Kalayjian - TOWARD Health

Food Junkies Podcast

Dr. Tro Kalayjian is a board-certified physician in Internal Medicine and Obesity Medicine, and the founder of Toward Health, a virtual metabolic health clinic helping people break free from food addiction and chronic metabolic disease. He’s also a founding member of the Society of Metabolic Health Practitioners and an international speaker on metabolic psychiatry, obesity, and nutrition science. But what makes Dr. Tro’s work truly powerful is that it’s personal. He grew up in a household affected by obesity and struggled with his own weight into adulthood, reaching over 350 pounds....

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Episode 240: Clinician's Corner - Chronic Invalidation show art Episode 240: Clinician's Corner - Chronic Invalidation

Food Junkies Podcast

In today's insightful Clinician’s Corner episode, Clarissa Kennedy and Molly Painschab delve into chronic invalidation as a trauma response, exploring its origins, impacts, and practical healing strategies. This episode offers clinicians compassionate insights and actionable tools for supporting clients on their healing journeys. Key Highlights: Understanding Chronic Invalidation Chronic invalidation occurs when emotions, needs, or perceptions are consistently dismissed, causing internalization of critical voices. Common invalidating statements include "You're too sensitive," "It's not that...

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Episode 239: Dr. Claire Wilcox - Rewire Your Food-Addicted Brain: Fight Cravings and Break Free from a High-Sugar, Ultra-Processed Diet Using Neuroscience show art Episode 239: Dr. Claire Wilcox - Rewire Your Food-Addicted Brain: Fight Cravings and Break Free from a High-Sugar, Ultra-Processed Diet Using Neuroscience

Food Junkies Podcast

We’re honored to welcome back Dr. Claire Wilcox, a trailblazer in the field of food addiction. Claire is an addiction psychiatrist, former internist, and associate professor of translational neuroscience at the Mind Research Network. She’s worked in everything from eating disorder treatment centers to general psychiatry and is on the frontlines of research, clinical care, and advocacy. Her academic textbook Food Addiction, Obesity and Disorders of Overeating has helped shape the professional dialogue—but today, we’re talking about her newest book, Rewire Your Food-Addicted Brain: Fight...

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Episode 238: Dr. Raphael E. Cuomo, Ph.D. - Addiction, Cancer & the Biology of Compulsion show art Episode 238: Dr. Raphael E. Cuomo, Ph.D. - Addiction, Cancer & the Biology of Compulsion

Food Junkies Podcast

In today’s episode, we explore the groundbreaking intersection of addiction, biology, and cancer with internationally recognized scientist Dr. Rafael Cuomo. Drawing on insights from his book Crave, Dr. Cuomo reveals how addiction is not simply a behavioral or psychological issue—it’s a biological condition that reshapes the terrain of our health and directly contributes to the development of chronic disease, including cancer. Dr. Cuomo introduces the concept of “molecular scars”—long-term physiological changes left behind by repeated addictive behaviors, even low-grade ones like...

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Episode 237: Dr. Hillary McBride - Reclaiming Embodiment After Spiritual Trauma show art Episode 237: Dr. Hillary McBride - Reclaiming Embodiment After Spiritual Trauma

Food Junkies Podcast

Dr. Hillary McBride is a therapist, researcher, speaker, and author dedicated to helping people grow, heal, and reconnect with their wholeness. With a PhD in Counselling Psychology from the University of British Columbia, she specializes in trauma, embodiment, eating disorders, perinatal mental health, and psychedelic integration. Known for making complex psychological concepts accessible and meaningful, Hillary is passionate about creating therapeutic spaces grounded in safety, trust, and hope. Her clinical work is informed by evidence-based, de-pathologizing approaches including AEDP, IFS,...

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Episode 236: Clinicans Corner - Post Event Collapse show art Episode 236: Clinicans Corner - Post Event Collapse

Food Junkies Podcast

In this compassionate and insightful episode, Clarissa and Molly dive into the phenomenon of post-event collapse—the physical, emotional, and psychological crash that can follow highly stimulating or meaningful experiences. Whether it’s a vacation, a major life event, a group share, or even just navigating a family gathering, many in food addiction recovery find themselves disoriented and vulnerable in the days that follow. They unpack the biology (hello dopamine crash), psychology (emotional contrast effects), and the nervous system’s role (freeze/dorsal vagal responses), and they offer...

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Episode 235: Dr. Diana Hill - Acceptance and Commitment Therapy show art Episode 235: Dr. Diana Hill - Acceptance and Commitment Therapy

Food Junkies Podcast

Dr. Diana Hill, PhD is a clinical psychologist and internationally recognized expert in Acceptance and Commitment Therapy (ACT) and compassion-based approaches to well-being. She is the host of the Wise Effort podcast and author of The Self-Compassion Daily Journal, ACT Daily Journal, and the forthcoming Wise Effort. Diana teaches individuals and organizations how to build psychological flexibility so they can live more aligned, courageous, and meaningful lives. I first discovered Diana and the transformative power of ACT through her course on using Acceptance and Commitment Therapy for eating...

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More Episodes

In this compelling episode, Dr. Vera Tarman interviews Dr. Thomas Seyfried, a pioneer in the field of cancer metabolism. Dr. Seyfried challenges the mainstream view of cancer as a genetic disease and presents strong evidence that cancer is fundamentally a mitochondrial metabolic disorder.

Dr. Thomas N. Seyfried is a distinguished American biologist and professor at Boston College, renowned for his pioneering work in cancer metabolism. With a Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, and postdoctoral training in neurochemistry at Yale University School of Medicine, Dr. Seyfried has dedicated his career to exploring the metabolic underpinnings of cancer and other neurological diseases.

Dr. Seyfried is best known for his groundbreaking book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (2012), where he presents compelling evidence that cancer is primarily a mitochondrial metabolic disorder rather than a genetic one. This perspective builds upon the early 20th-century findings of Otto Warburg, who observed that cancer cells rely heavily on fermentation for energy production, even in the presence of oxygen—a phenomenon known as the Warburg effect. Dr. Seyfried's research suggests that targeting cancer's metabolic dependencies, such as glucose and glutamine, through dietary interventions like the ketogenic diet, could offer non-toxic therapeutic strategies.


We explore:

How cancer cells fuel themselves differently from healthy cells
The connection between sugar, ultra-processed foods (UPFs), and cancer growth
The Warburg Effect and the roles of glucose and glutamine in tumor development
Whether refined sugar is carcinogenic like tobacco
Why Dr. Seyfried believes ketogenic diets and caloric restriction can be powerful cancer therapies
How his views align with metabolic psychiatry (Dr. Chris Palmer’s Brain Energy)
The controversial yet promising approach of "press-pulse" therapy
The potential for preventing cancer through dietary change

Follow:

https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.html

https://tomseyfried.com

The content of our show is educational only. It does not supplement or supersede your healthcare provider's professional relationship and direction. Always seek the advice of your physician or other qualified mental health providers with any questions you may have regarding a medical condition, substance use disorder, or mental health concern.