308: Fasting, Nicotine, and Microdosing LSD for Optimal Health Ft Sean McCormick
Release Date: 08/11/2025
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info_outlineHave you ever considered dry fasting for five days to regenerate your body, or using a pendulum to shift energy and reduce pain? I'm sharing some wild ideas today.
I talked with Sean McCormick, host of the Optimal Performance podcast and a human guinea pig for health experiments. We discussed the kettlebell mile, a test of strength and endurance, and how grip strength predicts longevity. Sean shared insights on nicotine as a neuroprotectant and its effects. We explored the deep benefits of dry fasting, including muscle preservation and fat loss. Sean also described using a pendulum to harmonize energy and reduce pain. He shared his experiences with mini-dosing LSD for creativity and focus. I learned about the importance of N of one experiments for personal health journeys.
Key takeaways
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Grip strength is an indicator of longevity, and tests like the kettlebell mile assess both strength and aerobic capacity.
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A dopamine detox protocol can help reset your body and mental clarity.
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Dry fasting for multiple days (without food or water) can regenerate the body on a cellular level, preserve muscle, and lead to significant fat loss, reaching deep ketosis and stem cell activation.
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Nicotine has potential benefits as a neuroprotectant, nootropic, and may offer anti-bacterial or anti-parasitic properties, but it can be addictive and is a vasoconstrictor.
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Oral TRT offers a different approach to testosterone replacement by providing mini-doses that may not hijack natural production.
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Herbal supplements, like dried ants, are used in traditional practices for physical strength.
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Pendulums made of magnetic metals can be used in energy medicine to harmonize energetic points, transmute negative energies, and potentially reduce pain.
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Microdosing or mini-dosing psychedelics like LSD or psilocybin can enhance creativity, focus, and offer anti-inflammatory effects, and can improve cognition.
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Conducting "N of one" experiments is a critical and fun way to learn about your own body's response to different health and fitness protocols.
Resources
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Optimal Performance podcast hosted by Sean McCormick https://podcasts.apple.com/us/podcast/optimal-performance/id1004775385 .
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The Real Sean McCormick on Instagram. https://www.instagram.com/realseanmccormick/?hl=en
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Lost Empire Herbs, founded by Logan Christopher. https://lostempireherbs.com
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SETT, a company offering a nicotine alternative pouch. https://www.getsett.co/
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Dry Fast With Friends.com, co-founded by Sean McCormick and Theo Lucier, offering dry fasting protocols and support. https://dryfastwithfriends.com
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Dr. Artis (guest on Optimal Performance podcast discussing viruses and nicotine). https://podcasts.apple.com/us/podcast/522-moving-beyond-the-covid-19-lies-with-dr-ardis-must-listen/id1004775385?i=1000714134256
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Will Blunderfield (Naked Yogi Canadian, discussed German New Medicine). https://willblunderfield.ca
The founder of The Million Dollar Body and author of "The Million Dollar Body Method", Nate has been coaching for over 15 years and has worked personally with over 1,000 clients.
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Website: https://milliondollarbodylabs.com/
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Lean Energy Stack: https://milliondollarbodylabs.com/pages/lean
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Instagram: @_milliondollarbody