Rethinking Treatment: Why It’s Not One Drug for One Disease Anymore w/ Sebastian Denison
Release Date: 05/15/2025
The Hidden Toxin Crisis and the Protocol That Actually Works w/ Paul Savage
The Trusted Pharmacist
Most people are toxic, and they don’t even know it. Their bodies are carrying a hidden load of chemicals, heavy metals, and environmental toxins picked up over years of daily life. In our modern society, no one’s safe from this. According to Dr. Paul Savage, a functional medicine expert and founder of one of the nation’s leading longevity clinics, this toxic burden is the silent culprit behind many of today’s most common health struggles. If you’ve tried everything: cleanses, fasting, supplements, sauna sessions, and you’re still battling fatigue, inflammation, brain fog, hormone...
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The Magnesium Deep Dive You Didn’t Know You Needed
The Trusted Pharmacist
IMPORTANT CORRECTION: I mentioned that Magnesium impacts 3000 enzymatic processes. I meant to say 300 (which is a big difference). The correct answer is that Magnesium impacts 300 enzymatic processes. The truth is important, and when we make a mistake, we own it. Magnesium is having a moment right now, and it’s easy to understand why. This gentle and inexpensive supplement might be the most underrated mineral in your health toolbox. It can help with everything from menstrual cramps and mood swings to blood pressure, weight loss, fatigue, and brain fog. But when it comes to magnesium,...
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Perimenopause: The Overlooked Phase Every Woman Needs to Understand w/ Dr. Dian Ginsberg
The Trusted Pharmacist
Perimenopause is the beginning of profound changes in your body that can go unnoticed until it’s too late. Many women don’t realize that perimenopause (the stage leading up to menopause) is when the hormonal rollercoaster truly begins. But by the time you start having symptoms like mood swings, irregular periods, or sleep disturbances, the imbalance may already be well underway. In this episode, Dr. Dian Ginsberg, a dual board-certified OB-GYN and anti-aging expert, shares why perimenopause is often the most overlooked phase in women’s health. What should perimenopausal...
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Rethinking Treatment: Why It’s Not One Drug for One Disease Anymore w/ Sebastian Denison
The Trusted Pharmacist
If you think pharmacy is still a “one drug for one disease” model, think again. People don’t get sick in a single silo, so why would we treat them that way? That’s why pharmacists today are unleashing the power of repurposing a drug at a lower dosage to get a benefit. Sebastian Denison, a compounding pharmacist on the frontlines of this shift, is the perfect person to have this conversation with! Using medications like low-dose Naltrexone, we’re able to tap into multiple mechanisms at once, reduce inflammation, calm an overactive immune system, and support whole-body healing! For too...
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Insulin Resistance 101: The Hidden Roadblock to Weight Loss & Energy
The Trusted Pharmacist
If you’re struggling with belly fat, stubborn weight gain, and food cravings that won’t go away, you might be dealing with insulin resistance. Maybe you eat healthy, exercise, and try to make all the "right" choices. But despite your best efforts, the scale won't budge, your cravings rage on, and your energy tanks halfway through the day. You’re not lazy, undisciplined, or broken. Your body’s internal system for managing blood sugar and energy has started to malfunction. This hidden process affects millions of people without obvious warning signs. Traditional lab work often misses it...
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Autoimmune Disease Doesn’t Just “Happen”—Here’s What Triggers It
The Trusted Pharmacist
Ever feel like your body is working against you—like you’re doing everything “right,” but you’re still exhausted, inflamed, or dealing with weird symptoms no one can explain? You might be dealing with an autoimmune disease, something that affects more Americans than cancer and heart disease combined. And yet, autoimmune diseases are often misunderstood and misdiagnosed. And here’s what’s rarely talked about: they can develop silently for years before symptoms ever appear. That’s why understanding autoimmune disease requires more than just managing symptoms. It demands...
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The Chronic Inflammation Crisis and How to Reverse It
The Trusted Pharmacist
Inflammation may be the body’s own protective process that helps us heal, but it’s something we don’t want too much of. In the right amount, it’s essential. It helps us recover from a broken bone, fight off infections, and calm down irritated skin. In excess, inflammation can actually trigger the very diseases it was meant to protect us from. We’re not just talking about a swollen ankle or a red rash. What I’m talking about here is chronic inflammation, a low-grade, long-term state of internal stress that quietly fuels disease in the background. Chronic inflammation...
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Menopause Isn’t the End: How to Harness Hormones and Stay Healthy
The Trusted Pharmacist
Thanks to the shortcomings of traditional healthcare, women have been led to believe that menopause is a time when their bodies fall apart, and there's nothing they can do about it. The sleepless nights, stubborn weight gain, mood swings, and discomfort? That’s just a “natural” part of aging, they’re told. But it doesn’t have to be that way. Menopause isn’t the end. It’s a powerful opportunity to reclaim your health, elevate your quality of life, and confidently step into this next chapter. And the most effective way to do that? Hormone replacement therapy. The...
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Why Menopause Care Should Be as Unique as You Are w/ Dr. Pamela Smith
The Trusted Pharmacist
Aging is inevitable, and every woman goes through menopause. But your hormonal journey and how your body responds? That’s unique to you. The problem is, a lot of what we’ve been told about menopause— even in clinics, pharmacies, and doctor’s offices—just isn’t accurate. Traditional healthcare often treats menopause like a one-size-fits-all situation, missing the mark on the unique needs of every woman’s body. That’s why a personalized approach isn’t just a nice-to-have—it’s the key to feeling your best through this transition. Hormones play a major role in...
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GLP-1 Medications: How They Work and How to Make Them Work for You
The Trusted Pharmacist
GLP-1 medications have quickly taken the world by storm—and for good reason. Just last year, over 90 million prescriptions for these medications were filled, and that number is only growing. Here’s why. In my years as a pharmacist, I’ve never seen a drug like this. Medications like Ozempic and Mounjaro have revolutionized weight loss treatments, offering dramatic results for many. But before you jump in, it’s important to understand that these drugs are not a quick fix. Without a solid plan, you could set yourself up for disappointment. One key thing to know if you're...
info_outlineIf you think pharmacy is still a “one drug for one disease” model, think again. People don’t get sick in a single silo, so why would we treat them that way?
That’s why pharmacists today are unleashing the power of repurposing a drug at a lower dosage to get a benefit.
Sebastian Denison, a compounding pharmacist on the frontlines of this shift, is the perfect person to have this conversation with!
Using medications like low-dose Naltrexone, we’re able to tap into multiple mechanisms at once, reduce inflammation, calm an overactive immune system, and support whole-body healing!
For too long, modern medicine has focused on treating isolated symptoms, prescribing one drug for one receptor, one diagnosis, one problem.
But the body doesn’t work that way. Everything is connected.
This new model of pharmacy looks at the entire person and provides multifaceted solutions.
In this episode, we explore why it’s time to stop treating disease in isolation and how forward-thinking pharmacists are using multi-targeted, low-dose therapies to reach far beyond a single symptom or receptor site.
Things You’ll Learn In This Episode
-Why “one drug, one receptor” is an outdated myth
The days of single-function prescriptions are over. How are today’s compounds designed to work across systems, supporting your body’s natural healing intelligence?
-Modulation not suppression
Inflammation in the body is like a dial, you have to find the right balance. How do we pull away from dysfunctional inflammation and get back to healthy inflammation?
-The problem with extremes (even healthy ones)
In excess, even the healthiest activities can be detrimental to your health and lead to chronic inflammation. How does living in extremes lead to a stressed-out body?
Guest Bio
Sebastian Denison, BScPharm, RPh, is a PCCA Training and Education Pharmacist who received his BSc in Pharmacy at the University of British Columbia. He worked at Northmount Pharmacy in North Vancouver for 11 years specializing in BHRT, veterinarian, pain and sports compounding practice. He also was the Manager of Pharmacy Operations with the 2010 Vancouver Winter Olympic/Paralympic Games, and then the Manager of the Whistler Olympic Village Polyclinic Pharmacy. Sebastian works with both the U.S and Canadian C3 education teams, the Pharmacy Student education team, and also does pharmacist education symposiums and events. Sebastian enjoys all aspects of compounding and appreciates its value in a collaborative approach to patient care.
About Your Host
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
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