π«π₯ βLung Clues & Blood Blues: How Tiny Lung Vesicles Spark Deadly Cancer Clotsβ π§¬π©Έ
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π©Έ Summary: Lung interstitial macrophages, activated by tumor-derived CXCL13, release integrin Ξ²2βΊ extracellular vesicles (sEVs) 𧬠that bind platelet GPIb π§², triggering clot formation across the body. These sEVs are both a driver of cancer-associated thrombosis and a potential biomarker for early risk detection π―, offering safer, targeted therapeutic opportunities π.
info_outline
Inflammation π₯, Dopamine π, and Apathy π: A Neuroimmune Pathway in Brain Fog?
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Cancer cachexia isnβt just weight lossβitβs a hijacking of motivation π. Elevated IL-6 π₯ activates a brainstem-to-basal ganglia circuit π§ that suppresses dopamine π in the nucleus accumbens, leading to effort-based apathy π€. Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway π‘.
info_outline
βπ§ Fewer Strokes, π« No Bleeds, β
Stronger Choice: Clopidogrel After PCI?
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π§ͺ SMART-CHOICE 3 in a Nutshell π£ Clopidogrel beat π aspirin post-PCI: π Fewer MACCE (4.4% vs 6.6%) π©Έ Same bleeding risk π½οΈ Fewer GI events β οΈ Editorial: Fragile stats, late benefit, open questions on lifelong therapy. π― Verdict: Promisingβbut not bulletproof.
info_outline
Mitochondria. Medicine. Miracles
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π Mitochondrial transplants are emerging as a powerful therapy to repair damaged cells, boost energy, and even reverse aging. From saving π« baby hearts to protecting π§ stroke-affected brains, this tiny powerhouse may revolutionize medicineβone cell at a time. π§¬πβ¨
info_outline
Dr. RR Baligaβs Philosophical Discourses: Plato (Greece, 427β347 BCE) β Founder of the Academy
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Plato (c. 428-348 BCE), a foundational figure in Western philosophy, was a student of Socrates and teacher of Aristotle. He established the Academy in Athens and is known for his theory of Forms, dialogues on justice, ethics, and politics, and lasting influence on philosophy, science, and education.
info_outline
Mitochondria the Tiny Travelers, Big Impact, Bold Future
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
𧬠Mitochondria are on the move! Once thought to stay put, these powerhouses travel between cells πβhealing neurons π§ , boosting immunity π‘οΈ, and even aiding cancer cells β οΈ. Scientists are now exploring how to harness this dynamic dance for future therapies π.
info_outline
From Cold to Bold: The Legacy of Winter Conception
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
βοΈ Conceived in the Cold? Individuals conceived during colder months show higher brown fat activity, increased thermogenesis, and lower BMI as adults. π¬ Using PET/CT, NIR-TRS, and doubly labeled water (DLW), the study linked preconception cold exposure to greater energy expenditure and reduced visceral fat. 𧬠The key factor: Temperature and its diurnal variation before conception β not birth season β predicts adult brown adipose tissue (BAT) function. π Cold-induced BAT activation leads to better cold adaptation, improved CIT, DIT, and total energy expenditure...
info_outline
βHeart on Fire? Timing Colchicine Right β³π§―π₯β
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Colchicine π, once a humble gout remedy, is now reshaping coronary care π«. Trials show it reduces events in stable CAD β , but its benefit post-MI βοΈ depends on timing β°. Inflammation matters β and so does when we strike. Colchicine in CAD: Small Pill, Big Debate ππ₯π« An ancient anti-inflammatory has found new life in cardiology β reducing heart attacks when started late, but disappointing when given early after an MI. Bottom Line: Timing matters. Too soon, and it fizzles. Wait until the fire cools, and colchicine shines. β°β¨
info_outline
The Kilimanjaro Cure ππ₯¬:: π§¬: How Heritage Diets Heal
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
πΏ Switching to a Western diet π increased inflammation π₯ and metabolic dysfunction. π Mbege and traditional foods calmed the immune system π§ and boosted IL-10 ποΈ.
info_outline
βSalted Truths: π§β€οΈβοΈ Rethinking Sodium for Heart and Kidney Healthβ
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Not all salts are created equal! π§ Sodium chloride raises blood pressure and harms the heart π, while sodium bicarbonate may protect kidneys and improve outcomes in CKD/HF patients π‘οΈπ«. Chloride channels (CLICs) play a hidden but vital role in heart health πβ€οΈ. We need large RCTs π§ͺπ to guide smarter, personalized salt strategies for better cardiovascular care π―π.
info_outlineπΆββοΈ The STRIDE trial tested semaglutide in patients with PAD and type 2 diabetes.
π Weekly injections for 52 weeks improved walking distance, pain-free mobility, and quality of life.
π Results showed significant gains vs placebo, with low adverse events.
π Semaglutide may offer a new stride forward in treating functional limitations in PAD.