270: Resiliency Radio with Dr. Jill: New Insights in MCAS & Premature Aging - “The O’Hara Syndrome”

In this episode, the Dr Jill was joined by Bob Miller and we delve into the intricate world of cellular health, focusing on the role of sirtuins, NAD, and the impact of environmental factors on chronic illnesses. The discussion is rich with scientific insights and practical advice for maintaining cellular health and preventing disease.

🔑 KEY DISCUSSIONS
① Sirtuins and Cellular Health:
👉 The episode explores the function of sirtuins, particularly SIRT1, SIRT2, and SIRT3, in maintaining cellular health. These proteins play crucial roles in regulating inflammation, energy production, and cellular repair.

② NAD and Its Importance:
👉 NAD (Nicotinamide Adenine Dinucleotide) is highlighted as a critical molecule for energy metabolism and cellular repair. The hosts discuss how genetic variations can affect NAD levels and contribute to a "perfect storm" of health issues.

③ Environmental and Genetic Factors:
👉 The conversation touches on how environmental toxins and genetic predispositions can lead to chronic illnesses. The hosts emphasize the importance of understanding these factors to manage and prevent diseases.

④ Pyroptosis and Inflammation:
👉 Pyroptosis, a form of programmed cell death associated with inflammation, is discussed. The hosts explain how this process can be both protective and harmful, depending on the context.

⑤ Role of Enzymes and Antioxidants:
👉 The episode covers the role of enzymes like PON1 and antioxidants in protecting cells from oxidative damage. The impact of glyphosate on these protective mechanisms is also examined.

⑥ Practical Health Tips:
👉  Listeners are provided with practical advice on dietary and lifestyle choices that can support cellular health, such as the use of fish oils and other anti-inflammatory nutrients.

🔑 KEY TAKEAWAYS
📌 Understanding the interplay between genetics, environment, and cellular processes is crucial for maintaining health.
📌 Supporting NAD levels and sirtuin activity can be beneficial for energy metabolism and reducing inflammation.
📌 Awareness of environmental toxins and their impact on health can guide better lifestyle choices.

👍 CONCLUSION
This episode offers a deep dive into the biochemical processes that underpin health and disease, providing listeners with valuable insights into how they can optimize their health through informed choices and a better understanding of their body's needs.

👨‍⚕️ Bob Miller 
Bob Miller is a Certified Traditional Naturopath with over 25 years of clinical experience and the founder of the Tree of Life practice in Pennsylvania.

He's also the visionary behind the NutriGenetic Research Institute, where he leads cutting-edge research into how genetic variants influence chronic illness, with a special focus on many conditions like Lyme disease and MCAS. Through his work, Bob has helped train hundreds of health professionals in functional genomics, a growing field that explores how our genes impact everything from detoxification to inflammation.

He's also the creator of the Functional Genomic Analysis software and the formulator behind numerous targeted nutritional supplements designed to support genetic weaknesses.