Get the STUCK Out

This podcast is about how to improve your brain health today and tomorrow using neuroscience, diet, lifestyle medicine and more. Topics include food, exercise, sleep, nature, modern medicine, psychedelics. I interview key experts and take you on deep dives into the latest research.

BONUS: 3 Foods That Age Your Body and Brain 02/21/2025

BONUS: 3 Foods That Age Your Body and Brain Food influences cellular aging. Avoiding certain foods may help protect your brain and body from premature aging. I discuss the science around 3 of these foods. Full article with references: Check out my newsletter! This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always consult your healthcare provider for individual recommendations and treatment. /episode/index/show/getthestuckout/id/35385425

Build Muscle to Boost Your Brain: Episode #20 02/12/2025

Build Muscle to Boost Your Brain: Episode #20 Groundbreaking research connects muscle mass to brain health. In this episode, you’ll discover how resistance training may help fight dementia and depression, why metabolic health starts with your muscles, and how specific nutrients and supplements can supercharge both body and mind. For my full free guide to this topic + all the studies I cited, along with a guide to top plant and animal based protein sources, head to Whether you're looking to future-proof your brain, optimize performance, or simply feel your best, this episode is your ultimate guide to harnessing the muscle-brain connection. Check out my newsletter! This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always consult your healthcare provider for individual recommendations and treatment. #health #neuroscience #brain #fitness #muscle #dementia #depression #protein /episode/index/show/getthestuckout/id/35263735

#19: How Inflammation Affects Mental Health 12/09/2024

#19: How Inflammation Affects Mental Health Chronic inflammation is convincingly linked to higher risk of psychiatric disorders. But how, and what can we do about it? We cover: inflammatory cytokines, the inflammatory hypothesis of depression, key pathways acted on by inflammation in the brain and the role of pharmaceuticals and lifestyle factors in acting on inflammatory pathways related to mental health. Check out the below blog for all the references Check out my newsletter! This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always consult your healthcare provider for individual recommendations and treatment. #food #diet #sugar #health /episode/index/show/getthestuckout/id/34341985

#18: What COFFEE Does to Your Brain 11/09/2024

#18: What COFFEE Does to Your Brain How Does Coffee Impact Your Brain? In this video we explore Brain Health, Alzheimer's Prevention, Mental Health, Mechanism, Dosing and Metabolism Check out the below blog for all the references Check out my newsletter! This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always consult your healthcare provider for individual recommendations and treatment. /episode/index/show/getthestuckout/id/33861487

#17: How to Optimize Your Brain Cells 10/19/2024

#17: How to Optimize Your Brain Cells In this episode, I discuss the four major types of brain cells, including neurons, microglia, astrocytes and oligodendrocytes, what they do and their role in brain health. I then discuss the research on what we can do to help optimize their function. Get my Free Guide: 11 Science-Backed Steps to Help Boost Memory and Prevent Dementia: Check out my free newsletter This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always consult your healthcare provider for individual recommendations and treatment. /episode/index/show/getthestuckout/id/33520557

How Creatine Boosts Your Brain 09/06/2024

How Creatine Boosts Your Brain Creatine May Have Brain and Muscle Benefits: Initially popular among athletes for muscle growth and performance, creatine is now recognized for its potential positive effects on brain function. Naturally occurring in the body, especially in muscles, supplementation can significantly boost its levels. Enhancing Brain Function: Studies suggest that creatine supplementation increases brain creatine levels, which may counter mental fatigue and enhance brain energy metabolism. It's particularly noted for improving memory, especially in older adults, and may also boost intelligence and reasoning abilities. Specific Benefits and Safety: Research indicates notable benefits of creatine supplementation for older adults, women, and those under metabolic stress. Concerns regarding kidney health have been largely dispelled, with studies suggesting safety in young adults and chronic renal disease patients. Optimal Use and Dosage: The most studied and accessible form of creatine is creatine monohydrate, with a general consensus on a dosage of around 5 grams per day. This dosage is believed to support both muscle and brain wellness effectively. This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always consult your healthcare provider for individual recommendations and treatment. /episode/index/show/getthestuckout/id/32947427

Short #6: Alcohol and the Brain 07/20/2024

Short #6: Alcohol and the Brain Alcohol use has been part of human culture for millennia. But modern research has revealed that ethanol may be a major risk for our brain health, and a potential brain booster. So, which is it? #alcohol #health #brainhealth #neuroscience Here's my full take: Want more brain science? Subcribe to my newsletter! This content is not intended to diagnose, treat, cure, or prevent disease. The information provided by this video should not be used as individual medical advice. You should always consult your healthcare provider for individual recommendations and treatment. /episode/index/show/getthestuckout/id/32227372

Short #5: 4 Ways to Boost Mood and Help Prevent Depression 04/29/2024

Short #5: 4 Ways to Boost Mood and Help Prevent Depression We've all heard about exercise for preventing cardiovascular disease and weight gain. But where is the conversation about lifestyle modification to prevent conditions like depression? We have more than enough data to recommend diet, exercise, sleep and mindful interventions, and given the incredible damage to our health posed by conditions like depression, I think it's high time we give preventive mental health the attention it deserves. Here's the latest research on science-backed ways to boost mood and prevent depression that we should all be aware of. Note: The information presented above is not a substitute for seeking professional medical guidance for mental health conditions. If you or someone you love is struggling significantly with poor mental health, you should get help from a qualified mental health provider. /episode/index/show/getthestuckout/id/31034378

Short #4: Plant Polyphenols for Brain Health 06/09/2023

Short #4: Plant Polyphenols for Brain Health There are thousands of molecules found in plants that are now known to impact everything from inflammation to the gut microbiome. They're called "polyphenols" and they may help explain why eating more whole plant foods is linked to better overall and brain health. For more, check out my website at Austinperlmutter.com /episode/index/show/getthestuckout/id/27092154

Short #3: 3 Keys To Brain Foods For Brain Health 05/23/2023

Short #3: 3 Keys To Brain Foods For Brain Health All of us hear about “superfoods” and amazing vitamins and minerals that will fix everything from poor memory to our mood. But what does the science say about the traits of the top foods for brain health? Here are some top takeaways: • Food turns into the building blocks for our brains, so eating more high-quality foods may be a good recipe for a higher-quality brain • Foods that are rich in polyphenols and antioxidants may be especially excellent for brain wellness (these are found in higher levels in herbs and spices!) • Certain fats (omega-3s in particular) seem to be key to brain health • Vitamins and minerals like zinc, magnesium and selenium are found in higher levels in nuts, seeds and leafy greens and are linked to better brain health, but by and large, eating a diversity of high-quality sources of especially plant and animal foods rich in vitamins and minerals seems key For more, check out my blog article For more free brain science, check out my weekly newsletter /episode/index/show/getthestuckout/id/26920527

Short #2: Brain Energetics, Mitochondrial Health, Metabolism and Lifestyle 05/13/2023

Short #2: Brain Energetics, Mitochondrial Health, Metabolism and Lifestyle Get the Stuck Out Shorts Your brain uses more energy (by weight) than any other organ in the body. Your 86 billion neurons each contain up to a million mitochondria, responsible for generating power to keep your thoughts and consciousness running. When things go wrong, we may be at higher risk for brain diseases. So how does this complex system work, and what might we be able to do to improve it? Dr. Austin Perlmutter explains. For a comprehensive + user friendly take on brain energy, Dr. Chris Palmer's "Brain Energy" book is great! #metabolism #brainhealth #brain #neuroscience /episode/index/show/getthestuckout/id/26828982

Short #1: Sugar, Erythritol and Brain Health 04/16/2023

Short #1: Sugar, Erythritol and Brain Health A recent study finds that erythritol may be bad for brain health. But how does sugar impact the brain overall, and what does the research say about sugar alternatives? Should we eat more honey? How does the microbiome factor in? For a nuanced conversation specific to the recent erythritol study, check out my blog at austinperlmutter.com/blog /episode/index/show/getthestuckout/id/26557110

#16: Serotonin and Depression 07/29/2022

#16: Serotonin and Depression Depression is a worldwide issue experienced by hundreds of millions. For years, the main theory of what was going wrong in the brain focused on the neurotransmitter serotonin. This theory is called the serotonin hypothesis, and it's based on a number of data points. But recently, researchers have questioned whether serotonin plays a central or even a major role in depression at all. In this episode, I explore: -The current landscape of depression -The serotonin hypothesis and issues with it -The recent publication "The serotonin theory of depression: a systematic umbrella review of the evidence" From Nature's Molecular Psychiatry -Other systems involved in the brain in depression like neuroplasticity, inflammation and the endocrine system -How this research links to diet, exercise and other lifestyle factors -Where we need to go next Let me know what you think! /episode/index/show/getthestuckout/id/23899407

#15: Fix Your Gut, Fix Your Health with Dr. Will Bulsiewicz 05/03/2022

#15: Fix Your Gut, Fix Your Health with Dr. Will Bulsiewicz In this episode of Get the STUCK Out, Dr. Will Bulsiewicz (Dr. B) explores the role of gut health on diseases like autoimmunity, allergy cancer and inflammation. We talk about the best diets to support gut health, and how the microbiome shapes us. We compare different diets (e.g keto and more plant based) for their effects on health and talk actionable strategies to improve gut health. You can find out more about Dr. B's new book on his website, theplantfedgut.com. For more tips and science on how to get your brain and body unstuck, join the thousands receiving my newsletter at austinperlmutter.com/newsletter. Don't forget to subscribe! /episode/index/show/getthestuckout/id/22971119

#14: The Brain Benefits of Nature 09/02/2021

#14: The Brain Benefits of Nature How does nature influence our brain function? /episode/index/show/getthestuckout/id/20342468

#13: Does COVID-19 Infect the Brain? 08/30/2021

#13: Does COVID-19 Infect the Brain? Deep dive episode! /episode/index/show/getthestuckout/id/20313323

#12 - Austin Perlmutter MD: Neuroplasticity, Depression, Psychedelics and Diet 07/22/2021

#12 - Austin Perlmutter MD: Neuroplasticity, Depression, Psychedelics and Diet In this episode, learn: /episode/index/show/getthestuckout/id/19897427

#11 - James S. Gordon MD: How to Transform Trauma 05/25/2021

#11 - James S. Gordon MD: How to Transform Trauma Trauma is certainly a popular topic of conversation these days. But few share the level of expertise offered by Dr. James. S. Gordon. Listen as he shares his years of clinical and research experience on how trauma manifests in the brain, body and psychological state, and what to do to start healing it. Dr. Gordon's new book Transforming Trauma is exceptional, and we discuss it in depth in this powerful interview. You can connect with Dr. Gordon at cmbm.org. /episode/index/show/getthestuckout/id/19240343

#10 - Dr. Dimitrios Tsatiris: To Have Anxiety is to be Human 03/02/2021

#10 - Dr. Dimitrios Tsatiris: To Have Anxiety is to be Human Anxiety is one of the most common states of stuckness today. In this episode I interview psychiatrist Dimitrios Tsatiris about his area of expertise: anxiety. We talk about what the term means, how it manifests, and what to do about it. Dr. Tsatiris is full of wonderful insight about this highly prevalent state, so you don't want to miss this one! /episode/index/show/getthestuckout/id/18160823

#9 - Dr. Ayesha and Dr. Dean Sherzai: Take a Deeper Look at Your Brain Health 02/04/2021

#9 - Dr. Ayesha and Dr. Dean Sherzai: Take a Deeper Look at Your Brain Health In this episode, I explore brain health with two physician scientists, Dr. Ayesha Sherzai and Dr. Dean Sherzai. It was one of my favorite conversations, filled with science, philosophy and psychology. We discuss the need for nuance and updated perspectives in scientific recommendations, the importance of listening to the community, and their powerful journey to becoming some of the leading brain health and brain nutrition experts. Be sure to check out their new book, The 30-Day Alzheimer's Solution! /episode/index/show/getthestuckout/id/17824448

#8 - Dr. Angela Reiersen: Depression, the Sigma 1 receptor and COVID-19 01/27/2021

#8 - Dr. Angela Reiersen: Depression, the Sigma 1 receptor and COVID-19 In this episode I speak with Psychiatrist and researcher Dr. Angela Reiersen about her recent publication in JAMA, "Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19." We discuss how she stays focused, the interaction between antidepressants and inflammation and depression as a biological disease. We finish up with her insights in children's psychological health as it relates to executive functioning during the pandemic. /episode/index/show/getthestuckout/id/17713838

#7 - Dr. Wendy Wood: Habits, Social Media and Behavior Change 12/30/2020

#7 - Dr. Wendy Wood: Habits, Social Media and Behavior Change In this episode of GTSO, I interview Wendy Wood, Ph.D. Wendy is a the Provost Professor of Psychology and Business at the University of Southern California and a prolific researcher in the field of habits. Her research addresses the ways that habits guide behavior—and why they are so difficult to break. She's one of the world's experts on habits, and shares some powerful wisdom on how to leverage this information for behavior change. She is author of the book, Good Habits, Bad Habits (2019). /episode/index/show/getthestuckout/id/17374097

Get The STUCK Out Episode 6 11/18/2020

Get The STUCK Out Episode 6 In this short solo episode, I dissect the concept of plasticity and its role in enabling humans to be successful and adapt to changing environmental pressures. I discuss plasticity as it relates to our psychology, immune function and most notably, our brain function (neuroplasticity). I conclude by explaining why this is so relevant in the age of stress, fear and anxiety inducing content as well as our generally poor dietary choices. /episode/index/show/getthestuckout/id/16852823

Get The STUCK Out Episode 5 10/27/2020

Get The STUCK Out Episode 5 In this information-packed episode, I speak with Dr. Casey Means, an MD with a passion for maximizing human potential and reversing the epidemic of preventable chronic disease through tech-enabled tools. We discuss her journey in the medical world and spend time digging into the details of glucose, insulin, and continuous glucose monitoring. /episode/index/show/getthestuckout/id/16567025

Get The STUCK OUT Episode 4 09/03/2020

Get The STUCK OUT Episode 4 In this overview episode, I begin to dive into the ways that what we take as true can be distorted, fabricated, or otherwise replaced by fiction. Examples I cover include popular social myths, the way that our medical research can be flawed, and the way our psychological operating system tends to distort truth. /episode/index/show/getthestuckout/id/15877667

Get the STUCK Out Episode 3 08/26/2020

Get the STUCK Out Episode 3 In this episode, I continue to lay the groundwork for the series with an explanation of the importance of cycles of behavior and thought in our lives. I discuss what I believe to be the most damaging cycles today, as well as some basic strategies to escape their grasp. Finally, I cover the basic framework for creating new, healthy cycles. We'll be building on this idea throughout the podcast. /episode/index/show/getthestuckout/id/15771365

Get The STUCK Out: Episode 2 08/20/2020

Get The STUCK Out: Episode 2 All of us are trying to improve ourselves. Whether it's eating better, exercising, or calling our grandmothers on occasion, it's so much easier to say we're going to do something than make it happen. Our inability to change our behaviors is a stuck point in our lives, and it's time we address this with honest questioning. What works? What is just a myth? What is popular but has no basis in science? As always, I'd love to hear your thoughts, and if you're liking the content, be sure to subscribe! /episode/index/show/getthestuckout/id/15696425

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