Shawn Wells: This Step Makes EVERY Supplement Finally Work
Wellness + Wisdom with Josh Trent
Release Date: 03/17/2026
Wellness + Wisdom with Josh Trent
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info_outlineAre your supplements really working, or are you just wasting your money?
Josh Trent welcomes Shawn Wells on the Wellness + Wisdom podcast, episode 807, to reveal why your nervous system determines whether your supplements work or do nothing, how chronic stress physically blocks absorption no matter the quality of what you're taking, the science of placebo and nocebo and how your mindset before you swallow the pill changes your biology, and why your body has to be ready before anything in the bottle can help.
25% off UPDATE Paraxanthine Drink

The Next Era of Energy: Be alert, not overstimulated. Paraxanthine powers a wakefulness you'll actually enjoy.
Upgrade your attention span with ingredients that enhance concentration and get a dopamine boost with paraxanthine and powerful nootropics.
Paraxanthine elevates you beyond the baseline in a way that caffeine simply cannot. It's one of the three metabolites of caffeine and is the compound that produces the energetic and focus effects we love from caffeine.
The other two metabolites, theobromine and theophylline are excluded in order to eliminate the side effects of jitters, anxiety, overstimulation, and the dreaded caffeine crash.
In This Episode, Shawn Wells Uncovers:
[01:30] Why Your Body Rejects Supplements
- Why supplements don't work when we're in a state of fear and overwhelm.
- How the liver blocks the benefits of supplements.
- Why the body get into a survival state.
- How the nervous system impacts the effects of supplements.
Resources:
- Shawn Wells
- 694 Shawn Wells | Your Ultimate Guide To Healing Mental + Physical Health
- 618 Shawn Wells + Daniel Solomons | Paraxanthine: UPDATE Your Energy + Vitality Without Caffeine
- 359 Shawn Wells: Ingredients For Healing, Self Love, & Mental Health
[08:55] Neural System Healing
- The importance of relaxing the neural system before a plant medicine ceremony.
- How breathwork helped Shawn regulate his neural system.
- Why grief is necessary in returning to a parasympathetic state.
[12:35] Why Placebo Actually Works
- Why supplements work through the placebo and nocebo effect.
- How the mind influences the results and efficiency.
- Why a dysregulated body doesn't metabolize supplements.
- How the sympathetic neural system makes the metabolization process longer.
- The most energy-dependent cells in the body.
- Why prayer before eating enhances the nourishment we get from food.
Resources:
[21:35] You Don't Have to Be Defined By What You Do
- Why we don't feel worthy of feeling safe.
- How most of us are stuck in doing too much.
- Why people judge each other and ourselves by what we do.
- The importance of connecting with God, nature, people, and ourselves.
Resources:
[26:50] The Key to Supplement Efficiency
- How the body creates shortcuts when we take supplements.
- Why we can prime our body through consistent habits.
- How we can create an anchoring system to get ourselves into a desired state.
- How different vitamins are stored in different parts of the body.
- What the ideal amount of stress is for us.
- How too much stress hijacks our adaptation capacity.
Resources:
[34:00] Why Medications Don't Work Long-Term
- How a parasympathetic neural state positively impacts nutrient absorption.
- Why the deepest states of meditation and zen make our brain more moldable.
- How we can rewrite our symptoms.
- Why medical drugs only work in acute cases, but not in long-term.
Resources:
- Nutraceuticals in the management of autonomic function and related disorders: A comprehensive review
[40:35] The Journey of Grief
- Why we are the ones who block ourselves from the life we want.
- What Shawn expected from going to Costa Rica.
- How he was seeking validation from women.
- Why being alone helped him process his grief.
- How we lie to ourselves, and our body doesn't believe us.
Resources:
[47:35] You Don't Need Supplements
- The importance of aligning all five sides of our wellness pentagon.
- Why we don't truly need supplements.
- How supplements teach us how to get to homeostasis.
- The difference between the impact of acute and chronic stress.
- How we can find out if we're in an acute or chronic stress state.
[54:30] Caffeine Is Toxic, Paraxanthine Heals You
- Why paraxanthine offers different benefits than caffeine.
- How chronic stress and overwhelm creates decision fatigue that keeps us out of integrity.
- Why doing hard things makes the idea of doing hard things easier.
- How we can't get more energy from a body that's overwhelmed.
- Why caffeine is toxic to most people.
- The short-term and long-term benefits of taking paraxanthine.
[01:03:15] The World Needs Paraxanthine Right Now
- How paraxanthine improves physical performance.
- Why paraxanthine is solving the societal issue of depletion.
- How an overwhelmed neural system makes us not feel the effects of stimulants.
Resources:
Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice
[01:09:35] What Can You Do for Yourself?
- How over-supplementation is connected to a lack of self-love.
- Why we need to start thinking of supplements as teachers.
- How Shawn changed his identity.
- Why we're always projecting ourselves onto others.
- The reason why happiness is not a sustainable state of being.
Resources:
[01:16:00] Freedom Comes From Truth
- Why the inner work and relationships improve each other.
- How Shawn's strong work ethic comes from insecurity.
- Why the ultimate marker for success is freedom and truth.
- How Shawn had a realization that he can be loved for who he is, not just what he does.
"You don't need supplements. The supplements are the training wheels. They're showing your body how to do the things. If you were a Zen master, you could just drop in. But you need to take L-theanine, do the breathwork, take your kava shot, dim the lights, you need all of that. Those are training wheels to teach yourself how to do it on command." — Shawn Wells
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All Resources From This Episode
- Shawn Wells
- 694 Shawn Wells | Your Ultimate Guide To Healing Mental + Physical Health
- 618 Shawn Wells + Daniel Solomons | Paraxanthine: UPDATE Your Energy + Vitality Without Caffeine
- 359 Shawn Wells: Ingredients For Healing, Self Love, & Mental Health
- Placebo and nocebo effects: from observation to harnessing and clinical application
- The Surrender Experiment by Michael Singer
- 622 Scott Jackson | Mandorla Integral Wisdom: Psycho-Spiritual-Emotional Ascension To THRIVE In Modernity
- Nutraceuticals in the management of autonomic function and related disorders: A comprehensive review
- 748 If Talk Therapy Worked, You’d Feel Better: New MDMA Therapy Breakthrough | Mike Zeller
- Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice
- Inside Out (movie)
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